Basic Science Focus Forum Papers

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BIOMECHANICS 

Reverse Dynamization Accelerated Bone Healing in a Goat Osteotomy Model
Vaida Glatt, PhD; Mikhail Samchukov, MD; Alexander Cherkashin, MD; Christopher August Lobst, MD

“Stress Taper” Strategy in Plate Fixation Increases Failure Strength in a Cadaveric Femur Model - Jeremy Raducha, MD; Christopher Nacca, MD; Joseph Crisco, PhD; Andrew R. Evans, MD

Evaluation of Intramedullary Olecranon Screw Fixation for Simple Olecranon Fractures: A Biomechanical StudyKelly McKnight, MD; Tysen Timmer, MD;
Mikayla Forness; Alexander Chong, MSAE, MSME; Gorden David Potter, MD

The Effect of Proximal Tibiofibular Joint Dislocation on Knee Mechanics: Reduction and Fixation Matters - Erik Arthur Magnusson, MD; Scott Telfer, PhD; Kate Parker; Mia S. Hagen, MD; Michael Githens, MD; Reza Firoozabadi, MD

Patella Fracture Fixation: A Biomechanical Comparison of Cannulated Screws and Anterior Tension Band with Low-Profile, Multiplanar Mesh Plating
Brittany E. Homcha, MD; Trevin Cowman, BA; Madison Lynn Goss, BS; Gregory S. Lewis, PhD; J. Spence Reid, MD; Matthew Robert Garner, MD

QUANTIFYING FRACTURE HEALING 

Are Bone Turnover Markers Useful Surrogate Measures of Fracture Healing
After Intramedullary Fixation of Tibia and Femur Fractures?

Gerard Slobogean, MD, MPH, FRCSC; Nathan N. O’Hara, MHA; Zachary Hannan, BS; Sofia Bzovsky, MSc; Jonathan Derrick Adachi; Christopher Stewart, BA;
Chelsea S. Bahney, PhD; Sheila Sprague, PhD; Vita-Shock Investigators

mRUST Scores Can Describe Boney Union, But Can They Predict Patient Function and Pain? Eric J. Abbenhaus, MD; Gavin Santini Hautala; Josh Van Wyngaarden, DPT, PT; Cale Jacobs, PhD; Brian Noehren, PT, PhD; Paul Edward Matuszewski, MD

Local Infiltrative Analgesia of Murine Femur Fractures in Vivo Does Not Inhibit Fracture HealingAndrew Farley Tyler, MD, PhD; Jaimo Ahn, MD, PhD; Derek James Donegan, MD

Hemorrhagic Shock Affects Specific Immune Cell Populations in Early Fracture
Callus
- George Kolettis, MD; Kayla Delaney, BS; Jie Xie, MD, PhD; Jared A. Smith;
Fletcher A. White, MS, PhD; Roman Natoli, MD; Todd Owen McKinley, MD

INFECTION AND FRACTURE HEALING

Local Antibiotic Delivery via Calcium Sulfate for Orthopaedic Infections - Ashley Levack, MD; Daniel Driscoll, MD; Kathleen Turajane, BS; Ajay Premkumar, MD, MPH; Xu Yang, MD; Andy Miller, MD; Mathias P.G. Bostrom, MD; David Wellman MD; Alberto V. Carli, MD, MSc, FRCSC

Computational Analysis and Visualization of Biofilm Development on Implant
Materials
- Adrian Turcu, BA; Ellis Berns, BS; Caitlin Barrett; Carole Spake, MS;
Jacqueline Leong, BA; Christopher T. Born, MD; Dioscaris R. Garcia, PhD

Zapping Deep Tissue Infection with a Fast Setting Biodegradable Hydrogel
Yazan Honjol, BA, MD; Daniela Vieira, MSc; Samuel Angel, MSc; Edward J. Harvey, MD, MSc, FRCSC; Géraldine Merle

The Induced Membrane Technique: Effects of Antibiotic-Impregnated Spacers on Healing of a Critical-Size Femoral Defect in a Rat Model - Hening Sun, BS; Charles Godbout, PhD; Gareth Ryan, BS; Ikran Ali; Emil H. Schemitsch, MD; Aaron Nauth, MD

Skeletal Muscle Autografting Improves Bone Healing In Pigs with Segmental
Bone Defects and Volumetric Muscle Loss
- Roman Natoli, MD, PhD; Benjamin Corona, PhD; Alexander Brinker, BS; Caio De Andrade Staut, MD; Stephen K. Mendenhall; Melissa Kacena, PhD; Todd Owen McKinley, MD

POLYTRAUMA

Inflammatory Cytokines Provide Unique Predictive Value Beyond Injury Severity:
A Prospective Cohort Study of Orthopaedic Trauma Patients
- Arun Aneja, MD; David C. Landy, MD; Alejandro Marquez-Lara, MD, PhD; Boshen Liu, MD; Peter Mittwede, MD, PhD; Shea Comadoll, MD; George V. Russell, MD

Systemic Neutrophil Homeostasis Is Not Affected by Reaming Techniques for
Intramedullary Nailing in a Standardized Porcine Polytrauma Model

Michel Teuben, MD; Sascha Halvachizadeh, MD; Yannik Kalbas; Zhi Qiao; Nikola Cesarovic, DVM, PhD; Paolo Cinelli, PhD; Roman Pfeifer, MD; Hans-Christoph Pape, MD; TREAT Research Group

Individual Hypercoagulable and Inflammatory Response Following Surgical Fixation of Femur Fractures - Daniel You, MD; Robert Korley, MD; Paul James Duffy, MD; Ryan Martin, MD; Richard E. Buckley, MD; Andrea Soo MSc, PhD;
Prism Schneider, MD, PhD, FRCSC

Possible Therapeutic Application of CORM-3-Derived Carbon Monoxide in
Acute Limb Compartment Syndrome
- Patrick Wang, MD; Abdel-Rahman Lawendy, FRCS; Emil H. Schemitsch, MD; Aurelia Bihari, MSc,PhD

POST-TRAUMATIC OSTEOARTHRITIS

Articular Fracture in the Knee of T-Cell-Deficient Mice Results in More Severe Post-traumatic Arthritis - Michael W. Buchanan, BS; Bridgette D. Furman, BS; Jacob Zeitlin; Janet L, Huebner; John Yi, PhD; Virginia Byers Kraus, PhD; Steven A. Olson, MD

Protection and Prevention of Cartilage Damage in Rat Knee Osteoarthritis by
Arnebia Euchroma Extract
- Soheil Ashkani Esfahani, MD; Bart Lubberts; Rohan Bhimani, MBBS

Phosphodiesterase-5 Inhibition Improves Bone Regeneration at Early Stages of
Traumatic Avascular Necrosis of the Femoral Head in Rats
Andre Luiz Campos Pessoa, Dr; Victor Hugo Vieira De Oliveira Araujo, MSc; Ana Lucia Rosa Nascimento, MSc; Nelson Elias; Jorge José De Carvalho, PhD

FRACTURE HEALING: CELLS AND BONE GRAFTING 

Discordant Effects of Non-Steroidal Anti-Inflammatory Drugs on Human and
Mouse Skeletal Stem Cells from Acute Fractures
- Lawrence Henry Goodnough, MD; Thomas Han Ambrosi, MSc, PhD; Holly Steininger, BS; Julius A. Bishop, MD; Michael J. Gardner, MD; Charles K.F. Chan, PhD

The Effluent of Autologous Bone Graft Preparations Is a Good Source for Skeletal Stem Cells, Which Are Markedly Different from Mesenchymal Stromal Cells -  Kimberly Ann Grannis, MD; Mark A. Lee, MD; Fernando A. Fierro, PhD; Bryan Le; Wei Yao, MD

Effects of TXA on Human Osteoblasts as Proxy for Fracture Healing - William D. Rieger, BA; Adam Yoonjin Park, MD; James F. Kellam, MD, FRCSC; Catherine G. Ambrose, PhD

Atrophic Nonunions are Associated with Functional Defects in Human Skeletal
Stem Cells
- Lawrence Henry Goodnough, MD; Thomas Han Ambrosi, MSc, PhD;
Julius A. Bishop MD; Michael J. Gardner, MD; Charles K.F. Chan, PhD

What Happens on the Back Table? Viability and Osteogenic Potential of RIA Bone Graft as a Function of Time and Temperature - Adam Hadley Kantor, MD; William James Uffmann, MD; Lucas Scott Marchand, MD; Justin Haller, MD; Thomas F. Higgins, MD; David Lynn Rothberg, MD