Henry Goodnough, MD

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Henry Goodnough, MD

"The OTA resident grant award has provided a unique opportunity for me to do potentially impactful translational research during my residency training. As an orthopaedic surgery resident planning to pursue a fellowship and career in traumatology, my clinical interests are in fracture healing. During medical school, I obtained a PhD studying how bones develop from stem and progenitor cells. Now, my interests are in how the injured skeleton recapitulates this process of skeletal development during fracture healing.  Sometimes, fracture healing is impaired, such as in elderly or geriatric patients who sustain fragility fractures. My goal is define how fractures heal from the perspective of the human skeletal stem cell, and why healing is impaired in geriatric patients. Research funding is essential for any aspiring clinician-scientist, and through the resident grant award, the OTA has supported my project to identify stem cell-based defects in geriatric fragility fractures.  I hope that delineating the mechanisms by which stem cells are impaired in geriatric fracture healing will allow us to develop new diagnostic tools and cell-based therapies. These strategies have the potential to allow us to a) better counsel individual geriatric patients and minimize their risk of failed fracture healing, b) provide earlier diagnosis of delayed or failed healing, and c) augment geriatric fracture fixation with novel stem-cell based therapies. I am grateful to you and the OTA for your support of musculoskeletal research for residents, and share in the OTA’s mission of promoting excellence in care of the injured patient."

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