Grant Funding History

1990  1991  1992  1993  1994  1995  1996  1997  1998  1999  
2000  2001  2002  2003  2004  2005  2006  2007  2008  2009
2010  2011  2012  2013  2014  2015

 

 

OTA 2015 MEMBER RESEARCH GRANT AWARDS

(Grant Cycle: January 1, 2015- December 31, 2015

 

CLINICAL RESEARCH GRANTS (up to $40,000/year, 2 year Grant Cycle)

 

Grant Title

           Treatment of Periprosthetic Distal Femur Fractures: A Randomized Controlled Trial

           of Locking Plate Osteosynthesis versus Retrograde Intramedullary Nailing


Principal Investigator

           Aaron Nauth, MD, FRCSC

Co-Investigator

           Emil Schemitsch, MD, FRCSC

Requested Funds

           $78,749

Grant Funded By: Zimmer/OTA

________________________________________________________________________________

Grant Title

           Registry for Orthopaedic Trauma in Children (ROTC)

Principal Investigator

            Kelly VanderHave, MD

Co-Investigator

            N/A

Requested Funds

            $79,495

Grant Funded By: Cardinal/OTA

________________________________________________________________________________

Grant Title

            Bone Regeneration in Spaceflight

Principal Investigator

            Melissa Kacena, PhD

Co-Investigator

            Todd McKinley, MD

Requested Funds

            $50,000

Grant Funded By: OTA

_________________________________________________________________________________

Grant Title

            Suppression of Trauma-Induced Systemic Inflammation 

 Principal Investigator

             Dominik Haudenschild, PhD

Co-Investigator

             Mark Lee, MD

Requested Funds

             $50,000

Grant Funded By: Synthes/OTA

_________________________________________________________________________________

 Grant Title

            The Use of Thrombonoietin with Autologous Minced Muscle Grafts for the Repair

            of Volumetric Muscle Loss

Principal Investigator

            Benjamin Corona, PhD

Co-Investigator

            Todd McKinley, MD

Requested Funds

            $50,000

Grant Funded By: OTA

_________________________________________________________________________________

Grant Title

           The Ossabaw Pig as a Musculoskeletal Model for Type II DIabetes

Principal Investigator

            Robert Welch, DVM, PhD

Co-Investigator

            Adam Starr, MD

Requested Funds

            $47,874

Grant Funded By: OTA

 

OTA 2015 NATIONAL TRAUMA DATA BANK GRANT AWARDS

(Grant Cycle: 1/1/2015 - 12/31/2015)

 

Grant Title

             Comparison of Study Results Between the National Trauma Data Bank (NTDB)

             and Trauma Quality Improvement Program (TQIP): A Study of Femoral Diaphyseal

             Fractures

Principal Investigator

             Jonathan Grauer, MD

Co-Investigator

             Michael Leslie, DO

Requested Funds

              $3,850

Grant Funded By:

 

Grant Title

             Trauma Centers and Socioeconomic Status: Is the Mortality Benefit of Trauma

             Center Treatment Maintained Across Socioeconomic Strata

Principal Investigator

              Erik McDonald, MD

Co-Investigator

               Saam Morshed, MD, PhD, MPH

Requested Funds

                $16,870

Grant Funded By:

 

OTA 2015 RESIDENT GRANT AWARDS (up to $20,000)

(Grant Cycle: January 1, 2015 - December 31, 2015)

 


Principal Investigator

Evan Watts, MD

Co-Investigator

Emil Schemitsch, MD

Grant Title

What is the Effrect of Antibiotic Impregnated Bone Cement Spacers in the Healing Process of Large Bone Defects as Part of the Masqueiet Technique

Requested Funds

$20,000

Grant Funded By: OTA

_________________________________________________________________________________

Principal Investigator

Anthony Shyn Ding, MD

Co-Investigator Meir Marmor, MD

Grant Title

Bioelectrical Impedance in the Assessment of Fracture Healing

Requested Funds

$19,764

Grant Funded By: OTA

_________________________________________________________________________________

Principal Investigator

Daniel Elkin, MD

Co-Investigator

Michael Sirkin, MD

Grant Title

Tension Plate Versus Cannulated Anterior Tension Band Fixation for Patella Fractures: A Biomechanical Study

Requested Funds

$17,967

Grant Funded By: FOT/OTA

_________________________________________________________________________________

Principal Investigator

Marissa Bonyun, MD, MEd

Co-Investigator

Michael McKee, MD, FRCSC

Grant Title

A Retrospective Cohort Study of Short and Long-Term Reoperation Rates After Proximal Humerus Fracture Management in the Elderly

Requested Funds

$19,000

Grant Funded By: FOT/OTA

_________________________________________________________________________________

Principal Investigator

Basel Touban, MD

Co-Investigator

Mark Anders, MD

Grant Title

Frailty, Sarcopenia and Outcomes in Orthopaedic Trauma Patients

Requested Funds

$9,757

Grant Funded By: OTA

 

 

 OTA 2014 RESIDENT GRANT AWARDS (up to $20,000)

(Grant Cycle: June 1, 2014 - May 31, 2015)

 

Principal Investigator

Stephen J. Warner, MD, PhD

Co-Investigator

Joseph Lane, MD

Grant Title

Efficacy of NSAIDs for Pain Control Following Intertrochanteric Hip Fracture Fixation: A Randomized, Control Trial

Requested Funds

$18,176

Grant Funded By: 

________________________________________________________________________________

Principal Investigator

Michael Olsen, Md, PhD

Co-Investigator

Emil H. Schemitsch, MD, FRCSC

Grant Title

Biomechanical Determination of the Optimal Overlap Between a Sliding Hip Screw Plate and a Retrograde Intramedullary Nail for Repairing an Ipsilateral Intertrochanteric and Femur Shaft Fracture

Requested Funds

$19,980

Grant Funded By:

________________________________________________________________________________

Principal Investigator

Adam M. Wegner, MD, PhD

Co-Investigator

Mark A. Lee, MD

Grant Title

Nox4 as a Mediator of Post-traumatic Osteoarthritis and a Potential Target for Treatment

Requested Funds

$20,000

Grant Funded By:

_________________________________________________________________________________

Principal Investigator

David J. Tennent, Md

Co-Investigator

Daniel J. Stinner, MD

Grant Title

Locally Applied Vancomycin Powder: Effective or Gone Before We Know It?

Requested Funds

$18,522

Grant Funded By:

_________________________________________________________________________________

Principal Investigator

Anthony D. Bratton, MD

Co-Investigator

John Callaci, PhD

Grant Title

The Effect of Chronic Binge Alcohol Consumption on BMP-2 Antagonist Expression in a Rat Model

Requested Funds

$19,684

Grant Funded By:

________________________________________________________________________________

  

OTA 2014 GRANT AWARDS

(Grant Cycle: January 1, 2014 - December 31, 2014)

 

CLINICAL RESEARCH GRANTS (up to $40,000/year, 2 year Grant Cycle)

Grant Title

       Hemostasis in Open Acetabulum and Pelvic Ring Surgery Using Tranexamic Acid: A

       Prospective, Randomized, Controlled Study

Principal Investigator

        Brett D. Crist, MD

Co-Investigator

        William Harvin, MD

Requested Funds

        $41,524

Grant Funded By: Smith & Nephew/OTA

________________________________________________________________________________

Grant Title

        Muscle Atrophy Regulation in Older Adults with Hip Fracture and Potential Anabolic

        Approaches

Principal Investigator

        Micah Drummond, MD

Co-Investigator

        Thomas Higgins, MD

Requested Funds

         $72,910

Grant Funded By: Smith & Nephew/COTA

 

BASIC RESEARCH GRANTS(up to $25,000, 1 year Grant Cycle)

Grant Title

           Targeting Intracellular Staphylococcus Aureus to Lower Recurrence of Orthopaedic

            Infection

Principal Investigator

            Thomas Ellis, MD

Co-Investigator

             Paul Stooodley, MD and Jeffrey Granger, MD

Research Consultant

             Jason Calhoun, MD

Requested Funds

             $29,529

Grant Funded By: Smith & Nephew/COTA

________________________________________________________________________________

Grant Title

             Integrin Signaling and Hyaline Cartilage Response to Blunt Trauma

Principal Investigator

             Gregory Della Rocca, MD 

Co-Investigator

              Aaron Stoker, MD

Requested Funds

              $49,330

Grant Funded By: Smith & Nephew/COTA

_________________________________________________________________________________

 Grant Title

              Mediators of Acute Kidney Injury Following Orthopedic Trauma in Obese Rats

Principal Investigator

               Robert Hester, MD

Co-Investigator

               George Russell, MD

Requested Funds

               $50,000

Grant Funded By: Zimmer/OTA

_________________________________________________________________________________

 Grant Title

              Therapeutic Application of Carbon Monoxide (CO), Liberated from a Novel CO-

              Releasing Molecule (CORM-3), in a Large Animal Model of Limb Compartment

Principal Investigator

              Abdel-Rahman Lawendy, MD

Co-Investigator

             N/A

Requested Funds

             $50,000

Grant Funded By: OTA

________________________________________________________________________________

Grant Title

             Promoting Ischemic Fracture Healing By Blocking Inhibitors of Vascularization

Principal Investigator

             Jaimo Ahn, MD

Co-Investigator

             Kurt Hankenson, DVM, MS, PhD

Requested Funds

             $50,000

Grant Funded By: OTA

_________________________________________________________________________________

Grant Title

             The Use of Autologous Endothelial Progenitor Cells (EPCs) for the Healing of a

             Bone Defect in a Large Animal Model

Principal Investigator

              Aaron Nauth, MD

Co-Investigator

             Emil Schemitsch, MD

Requested Funds

             $50,000

Grant Funded By: OTA

_________________________________________________________________________________

 

OTA 2014 RESIDENT GRANT AWARDS (up to $20,000)

(Grant Cycle: January 1, 2014 - December 31, 2014)

Principal Investigator

Lyle T Jackson, MD

Co-Investigator

Kyle J Jeray, MD

Grant Title

Effects of Upper Extremity Immobilization and Use of a Spinner Knob on Vehicle Steering: A Prospective Study in Patients with Distal Radius Fractures

Requested Funds            

 $17,129

Grant Funded By: Smith & Nephew

________________________________________________________________________________

Principal Investigator

Justin Drager, MDCM, HBSc

Co-Investigator

Edward J Harvey, MDCM HBSc MSc FRCSC

Grant Title

Hypoxia Mimicking Agents for the Induction of Guided Angiogenesis in Calcium Phosphate Scaffolds for Bone Tissue Engineering of Posttraumatic Bone Defects

Requested Funds

$18,621

Grant Funded By: FOT/OTA

________________________________________________________________________________

Principal Investigator

Siddhant Kumar Mehta, MD

Co-Investigator

George Russell, MD

Grant Title

Effects of Selective Serotonin Reuptake Inhibitors Upon Fracture Healing

Requested Funds

$19,911

Grant Funded by: FOT/OTA

_________________________________________________________________________________

Principal Investigator

Jesse Otero, MD PhD

Co-Investigator

Nepola James, MD

Grant Title

The Effect of Timing of Amino-bisphosphonate Therapy on Fracture Healing in Osteoporosis: A Mammal Model

Requested Funds

$20,000

Grant Funded By: FOT/OTA

_________________________________________________________________________________

Principal Investigator

Andrew Pugely, MD

Co-Investigator

J Lawrence Marsh, MD

Grant Title

Development and Deployment of a Statewide Hip Fracture Morbidity and Mortality Risk Calculator

Requested Funds

420,000
Grant Funded By: Zimmer/OTA

_________________________________________________________________________________

  

2013 RESEARCH GRANT AWARDS

(Grant Cycle: January 1, 2013 - December 31, 2013)

 

CLINICAL GRANTS (up to $40,000/year, 2 year Grant Cycle)

 

Grant Title

           A Multicenter Prospective Cohort Study of Sacral Fractures using Patient Based

           and Objective Outcomes

Principal Investigator

           Paul Tornetta, III, MD

Co-Investigator

           Julie Agel, MA

Requested Funds

           $80,000

Grant Funded By:

_________________________________________________________________________________

Grant Title

           Does Residual Displacement after a Pelvic Ring Injury Impact Clinical Outcome?

Principal Investigator

           Steven Olson, MD

Co-Investigator

           Kyle J Jeray, MD

Requested Funds

           $80,000, but awarded $75,000

Grant Funded By:

_________________________________________________________________________________

Grant Title

          Locked Compression Plating Versus Cable Plating Combined with Strut Allografts             for Vancouver B1 Periprosthetic Femoral Fractures: A Randomized Controlled Trial

Principal Investigator

         Aaron Nauth, MD

Co-Investigator

         Emil Schemitsch, MD

Requested Funds

         $79,349

Grant Funded By:

 

Basic Research Grants (up to $25,000, 1 year Grant Cycle)

 

Grant Title

         Discovering the Mechanism of Age-Associated Impaired Healing in the Presence of

         Sustained Inflammation

Principal Investigator

         Theodore Miclau, MD

Co-Investigator

          Ralph Marcucio, PhD

Requested Funds

          $49,913

Grant Funded By:

_________________________________________________________________________________

Grant Title

          A Comparison of Endothelial Progenitor Cell (EPC) Based Gene Therapy Versus

          Mesenchymal Stem Cell (MSC) Based Gene Therapy for the Healing of Bone Defects

Principal Investigator

          Aaron Nauth, MD

Co-Investigator

          Emil Schemitsch, MD

Requested Funds

          $50,000

Grant Funded By:

_________________________________________________________________________________

Grant Title

          Infection Prevention in Long Bone Fracture Osteomyelitis Model Treated With IM

          Nail

Principal Investigator

          Andrew Schmidt, MD

Co-Principal Investigator

         Joan Bechtold, MD

Requested Funds

         $50,000

Grant Funded By:

_________________________________________________________________________________

Grant Title

         Simulation Approaches for Training in Fluoroscopically Guided Articular Fracture

         Strategy

Principal Investigator

         Matt Karam, MD

Co-Investigator

         J. Lawrence Marsh, MD

Requested Funds

         $50,000
Grant Funded By:

  

OTA 2013 RESIDENT RESEARCH GRANTS (up to $20,000)

(Grant Cycle: June 1, 2013 - May 31, 2014)

 

Principal Investigator

Jonathan Harris, MD

Co-Investigator

Jeffrey Anglen, MD

Grant Title

The Safety and Efficacy of Using Romiplostim for Bone Healing 

_________________________________________________________________________________

Principal Investigator

Motasem I Refaat, Md

Co-Investigator

Mark A. Lee, MD

Grant Title

Fixation Compliance and BMP Response

_________________________________________________________________________________

Principal Investigator

Prism Schneider, MD, PhD

Co-Investigator

Kevin Hildebrand, MD

Grant Title

The Dose-response Effect of the Mast Cell Stabilizer, Ketotifen Fumarate, on Post-traumatic Joint Contractures

________________________________________________________________________________

Principal Investigator

Timothy Sean Leroux, MD

Co-Investigator

Patrick David George Henry, MD, FRCSC

Grant Title
Assessing Knowledge Translation in Orthopaedic Surgery: A Time-Series Analysis of Midshaft Clavicle Fracture Fixation in Ontario, Canada

 

 2013 RESIDENT RESEARCH GRANTS (up to $20,000)

 (Grant Cycle: January 1, 2013 - December 31, 2013)

Principal Investigator

Ben Francisco, MD

Co-Investigator

Boris Zelle, MD

Grant Title

Cross Cultural Adaptation and Validation of the American Academy of Orthopaedic Surgeons Foot and Ankle Outcomes Questionnaire in Mexican-Americans

_________________________________________________________________________________

Principal Investigator

Jared Niska, MD

Co-Investigator

Devon Jeffcoat, MD

Grant Title

Covalently Linked Implant Coatings Containing Antibiotics and BMP-2 for Treatment of Open Fractures

________________________________________________________________________________

 Principal Investigator

Jose Oneto, MD, PhD

Co-Investigator

Mark Lee, MD

Grant Title

Covalent Targeting Project

_________________________________________________________________________________

Principal Investigator

Megan Mignemi, MD

Co-Investigator

William Obremsky, MD

Grant Title

Fibrin Accumulation Stimulates Heterotopic Ossification

 

OTA 2012 MEMBER RESEARCH GRANT AWARDS

(Grant Cycle: January 1, 2012 - December 31, 2012)

 

CLINICAL GRANTS (up to $40,000/year, 2 year Grant Cycle)

 

Grant Title

              Reamer Irrigator Aspirator (RIA) Versus Autogenous Iliac Crest Bone Graft

              (AICBG) For The Treatment Of Nonunions:  A Randomized Prospective, Multi-

             Centre, Clinical Trial

Principal Investigator

               Aaron Nauth        

Co-Investigator

               Emil Schemitsch
Requested Funds

                $79,500

Grant Funded by

                DePuy, A Johnson & Johnson Company/OTA

 ____________________________________________________________________________

Grant Title

                Negative Pressure Therapy Dressings Versus Standard Dressings for Closed

                Calcaneus Fractures:  a Prospective Randomized Study of Wound

                Complications & Infection

Principal Investigator

               Michael Archdeacon
Co-Investigator

               Camille Connelly
Requested Funds

               $37,750

Grant Funded By: OTA


Grant Title

                A Cognitive Behavioral Relaxation Response Training Intervention For Patients

                At Risk With History of Orthopedic Musculoskeletal Trauma

Principal Investigator

                Ana-Maria Vranceanu

Co-Investigator

               David Ring
Requested Funds

               $40,000

Grant Funded By: Smith & Nephew/OTA


 Grant Title

               Does Residual Displacement After a Pelvic Ring Injury Impact Clinical Outcome?

Principal Investigator

               Steven Olson, MD

Co-Investigator

Kyle J Jeray, MD

Requested Funds

$80,000 but awarded $75,000

 

 

Basic Research Grants (up to $25,000, 1 year Grant Cycle)

 

Grant Title

                Antimicrobial Photodynamic Therapy For Prevention And Treatment Of Surgical

                Site Infections

Principal Investigator

                Tianhong Dai

Co-Investigator

               Mark Vrahas

Requested Funds

                $25,000

Grant Funded By: OTA


Grant Title

                Bone Tissue Engineering Using A Scaffold Seeded With VEGF – Transfected

                Osteoblasts

Principal Investigator       

               Ru Li

Co-Investigator

              Emil Schemitsch

Requested Funds

              $25,000

Grant Funded By: OTA


Grant Title

                Adipose Derived Stem Cells In The Treatment Of Fractures With Bone Loss And

                Nonunions

Principal Investigator

                Robert Ostrum

Co-Investigator

               Thimas Tulenko
Requested Funds

               $22,724

Grant Funded by: OTA


Grant Title

                Expression of Single Nucleotide Polymorphisms in Delayed Fracture Healing

Principal Investigator

                John Reid             

Co-Investigator

                Vikram Sathyendra

Requested Funds

                $25,000

Grant Funded by: OTA


Grant Title

                Role Of Carbon Monoxide (CO), Liberated From A Novel CO-Releasing Molecule

                (CORM-3) In The Protection Of Skeletal Muscle Following Compartment

                Syndrome

Principal Investigator

                Abdel-Rahman Lawendy

Co-Investigator

               None Listed
Requested Funds

               $24,997

Grant Funded By: OTA


Grant Title

                Traumatic Cauda Equina Compression:  The Relationship Between The

                Duration Of Compression, Inflammation And Functional Outcomes In A Rat

                Model

Principal Investigator

                Chris Bailey
Co-Investigator

                David Sanders
Requested Funds

                $18,633

Grant Funded By: OTA


Grant Title

                Novel Therapeutic Approach To Improve Bone Health By Increasing Vascularity

                Of A Fracture Site Through The Application of Trophoblast Stem Cells

Principal Investigator       

                Chelsea Bahney

Co-Investigator

                Theodore Miclau

Requested Funds

                $25,000

Grant Funded By: OTA


Grant Title

                The Role Of G Protein-Coupled Estrogen Receptor 1 In The Fracture Healing Of

                Normal And Oophorectomized Mice

Principal Investigator

                Rahul Banerjee

Co-Investigator

                Brigham Au

Requested Funds

                $25,000

Grant Funded By: Zimmer/OTA             

 


 

OTA 2012 RESIDENT $10,000 GRANT AWARDS

(Grant Cycle:  June 1, 2012 - May 31, 2013 Grant Cycle) 

 

Principal Investigator

Justin Haller, MD

Co-Investigator

Thomas Higgins, MD

Grant Title

Inflammatory Response Following Intraarticular Fracture

Grant Funded by:  OTA

 ____________________________________________________________________________

Principal Investigator

Michael Willey, MD

Co-Investigator

Todd McKinley, MD

Grant Title

Articulated Joint Distraction in a Rabbit Knee Model of Post-Traumatic Osteoarthritis

Grant Funded by:   OTA

 ___________________________________________________________________________

Principal Investigator

David Shearer, MD

Co-Investigator

Saam Morshed, MD

Grant Title

Intramedullary Nailing Versus Plates for Femoral Shaft Fractures in Dar es Salaam, Tanzania with Minimum 1-Year Follow Up

Grant Funded by:  OTA

 ____________________________________________________________________________

Principal Investigator

Timothy Alton, MD

Co-Investigator

Sean Nork, MD

Grant Title

Skeletal Accumulation of Bisphosphonate Impairs Bone Healing

Grant Funded by:  OTA

____________________________________________________________________________

Principal Investigator

Stephen Gould, MD
Co-Investigator

Kenneth Egol, MD

Grant Title

Long Term Outcome of Surgery for Fractures of the Ankle

Grant Funded by:  OTA

 ____________________________________________________________________________

Principal Investigator

Michael Beebe, MD
Co-Investigator

Thomas Higgins, MD

Grant Title

A Descriptive Cohort Analysis of Gonadal Radiation Exposure and Risk Secondary to Fluoroscopic Imaging During Trauma Surgery about the Pelvis and Femur

Grant Funded by: OTA

 

 

OTA 2012 RESIDENT $10,000 GRANT AWARDS

(Grant Cycle:  January 1, 2012 - December 31, 2012 Grant Cycle) 

 

Principal Investigator

Scott Koenig, MD 

Co-Investigator

Paul Tornetta, MD 

Grant Title

Analysis Of Lateral Fluoroscopic Imaging To Assess The Quality Of Ankle Syndesmotic Reduction

Grant Funded by:  Foundation for Orthopaedic Trauma (FOT)/OTA

___________________________________________________________________________ 

Principal Investigator

Tom Chao, MD

Co-Investigator

David P. Zamorano, MD 

Grant Title

A Novel Method For Preservation Of The Neuromuscular Junction Using An Inhibitor To MMP-3

Grant Funded by: Foundation for Orthopaedic Trauma (FOT)/OTA

____________________________________________________________________________ 

Principal Investigator

Alison Kitay, MD 

Co-Investigator

Charles N. Cornell, MD

Grant Title

The Canonical Wnt Signaling Pathway Plays A Critical Role In The Etiology Of Age-Related Impaired Fracture Healing

Grant Funded by: Foundation for Orthopaedic Trauma (FOT)/OTA

 ___________________________________________________________________________

Principal Investigator

Clifford Lin, MD

Co-Investigator

Emil Schemitsch, MD

Grant Title

Effects of Endothelial Progenitor Cell Therapy on Diabetic Rat Fracture Healing

Grant Funded by: Medtronic/OTA

___________________________________________________________________________ 

Principal Investigator

Adam Wilson, MD
Co-Investigator

Francis H. Shen, MD

Grant Title

Human Adipose-Derived Stem Cells In Three-Dimensional Multicellular Aggregates As Autograft For Spinal Fusion: An In Vitro And In Vivo Study

Grant Funded by: Medtronic/OTA

___________________________________________________________________________ 

 Principal Investigator

David Wasserstein, MD
Co-Investigator

Richard Jenkinson, MD

Grant Title

Complications And Re-Operation After Tibial Plateau Fracture Fixation In A Large Population Cohort.

Grant Funded by: OTA

___________________________________________________________________________

Principal Investigator

Scott Yang, MD

Co-Investigator

Quanjun Cui, MD 

Grant Title

Modulation Of The Host Immune Response To Enhance Efficacy Of Allogeneic Mesenchymal Stem Cells

Grant Funded by: OTA

___________________________________________________________________________ 

Principal Investigator

Jonathan Chae, MD

Co-Investigator

Eric S. Moghadamian, MD 

Grant Title

Biomechanical Analysis Of Novel "Pauwels" Screw Fixation For Pauwels Type-III Vertical Sheer Femoral Neck Fractures 

Grant Funded By: OTA

__________________________________________________________________________ 

 Principal Investigator

Tarek Sibai, MD 

Co-Investigator

Paul Tornetta, MD 

Grant Title

A Pilot Study To Identify A Novel Radiographic View For Types 3 And 5 Acromio-Clavicular Joint Separations Predictive Of Long-Term Outcomes

Grant Funded By: OTA

____________________________________________________________________________

Principal Investigator

Daniel Stinner, MD

Co-Investigator

Joseph R. Hsu, MD 

Grant Title

Can Objective Feedback Improve Patient Centered Outcomes?  A Prospective Randomized Study

Grant Funded by: OTA

2011

 

 

OTA 2011 GRANT AWARDS

 (Grant Cycle:  January 1, 2011 – December 31, 2011)

 

 

 

 

 

Directed Topic Clinical Study (up to $50,000/year, 3-year funding cycle)
(Surgical Infection Prevention and Treatment)

 

 

Grant Title

Qualification and Susceptibilities of Microbial Flora in Open Fractures

Principal Investigator

Samir Mehta, MD               

Co-Investigator

Paul Matuszewski, MD
Requested Funds

$80,000


 

 

 

Clinical Grants (up to $40,000/year, 2 year Grant Cycle)

 

 

Grant Title

A Multicentre, Randomized Trial of Simple Decompression Versus Anterior Transposition of the Ulnar Nerve for Acute, Displaced Fractures of the Distal Humerus Treated With Plate Fixation

Principal Investigator

Emil Schemitsch, MD, FRCSC
Co-Investigator

Michael McKee, MD, FRCSC
Requested Funds

$78,630



Grant Title

A Multicentre, Randomized Trial of Conservative Treatment Versus Operative Plate Fixation for Acute, displaced Fractures of the Distal Clavicle

Principal Investigator

Jeremy Hall, MD, FRCSC
Co-Investigator

Michael Mckee, MD, FRCSC
Requested Funds

$80,000

Grant Funded by

COTA/Smith & Nephew


 

Grant Title

Randomized Clinical Trial of Suprapatellar Versus Infrapatellar Tibial Nailing

Principal Investigator

Roy Sanders
Co-Investigator

None Listed

Requested Funds

$38,680


 

 

 

Basic Research Grants (up to $25,000, 1 year Grant Cycle)

 

 

 

Grant Title

The Use of Implantable Radio-Frequency Micomachnined Capacitive Sensor Chips to Monitor Compartment Pressures in the Lower Limb

Principal Investigator

Edward Harvey, MD, MSc
Co-Investigator

Vamsy Chodavarapu, PhD

Requested Funds

$18,517.50


 

Grant Title

Forceps Reduction of the Syndesmosis in Rotational Ankle Fractures:  A Cadaveric Study and Prospective Case Series

Principal Investigator       

Phinit Phisitkul,. MD
Co-Investigator

Larry Marsh. MD

Requested Funds

$25,000
Grant Funded by

COTA/Smith & Nephew


Grant Title

Effect of BMP-2 and MP-7 on Articular Cartilage Following Impact Load

Principal Investigator

Paul Chin, MD, PhD
Co-Investigator

Joseph Borellli, Jr., MD
Requested Funds

$25,000
Grant Funded by

Medtronic


 

Grant Title

The Effect of Late Type Endothelial Progenitor Cells on Augmentation of Angiogensis and Osteogensis in a Segmental Bone Defect Model

Principal Investigator

Ru Li, PhD
Co-Investigator

Emil Schemitsch, MD
Requested Funds

$25,000

Grant Funded by

COTA/Smith & Nephew


 

 

OTA 2011 RESIDENT $10,000 GRANT AWARDS

(Grant Cycle:  January 1, 2011 - December 31, 2011 Grant Cycle)

Principal Investigator

Brian C. Werner, MD

Co-Investigator

Frank H. Shen, MD

Grant Title

Human Adipose-Derived Stem Cells In a PLGA Nanofiber Scaffold for Spine Fusion

Grant Funded by

______________________________________________________________________________

Principal Investigator

Dennis S. Meredith, MD

Co-Investigator

Joseph M. Lane, MD

Grant Title

The Effect of CT Scan Resolution on Fragility Fracture Risk Assessment Using the Heterogeneity of Bone Tissue Mineral Density

Grant Funded by

_______________________________________________________________________________

Principal Investigator

Scott Hadley, MD

Co-Investigator

Kenneth A. Egol, MD

Grant Title

The Role of Ankylosis Protein in Bone Healing

Grant Funded by

_______________________________________________________________________________

Principal Investigator

Eric F. Swart, MD

Co-Investigator

Melvin P. Rosenwasser, MD

Grant Title

A Complete Analysis of the Costs of Distal Radius Fractures

Grant Funded by

_______________________________________________________________________________

Principal Investigator

Sasha Carsen, MD

Co-Investigator

Feibel John Robert, MD

Grant Title

Post-Operative Radiographic Outcomes of Closed Diaphyseal Femur Fractures Treated with the SIGN Intra-Medullary Nail

Grant Funded by

_______________________________________________________________________________

Principal Investigator

Marie E. Walcott, MD

Co-Investigator

John J. Wixted, MD

Grant Title

Role of Htra 1 in the Transition from Cartilage to Bone in Fracture Healing

Grant Funded by

_______________________________________________________________________________

Principal Investigator

Josh Murphy, MD

Co-Investigator

Bruce H. Ziran, MD

Grant Title

Mechanical Competence of Antibiotic-Laden, Bioabsorbable Bone Cement

Grant Funded by

_______________________________________________________________________________

Principal Investigator

Britt Miller, MD

Co-Investigator

Bruce H. Ziran, MD

Grant Title

The Utility of Reprocessed Drill Bits for Surgery; Performance Characterization of OEM, Used, and Reprocessed

Grant Funded by

_______________________________________________________________________________

Principal Investigator

Matthew J. Dietz, MD

Co-Investigator

David F. Hubbard, MD

Grant Title

Vascularity of the Lateral Tibial Plafond After Ankle Fracture-Dislocation

Grant Funded by

_______________________________________________________________________________

Principal Investigator

Benjamin C. Taylor, MD

Co-Investigator

Kevin J. Pugh, MD

Grant Title

A Biomechanical Evaluation and Comparison of 6.5mm Cannulated Headless Compression Screws

Grant Funded by

_______________________________________________________________________________

Principal Investigator

Sanjit Konda, MD

Co-Investigator

Kenneth A. Egol, MD

Grant Title

CT Scan to Detect Intra-articular Air in Knee Joint - A Cadaver Model to Determine a Low Radiation Dose Imaging Protocol

Grant Funded by

_______________________________________________________________________________

                                       

 

OTA 2011 RESIDENT $10,000 GRANT AWARDS

(Grant Cycle:  June 1, 2010 – May 31, 2011)

 

 

Principal Investigator

Mitchell Bernstein, MD

Co-Investigator

Edward Harvey, MD

Grant Title

The Use of Contrast Media in Detecting Traumatic Knee Arthrotomy

Grant Funded by

 


 

Principal Investigator

Paul Chin, MD, PhD

Co-Investigator

Joseph Borrelli, Jr, MD

Grant Title

Effect of BMP-7 on Articular Cartilage Following an Impact Load

Grant Funded by

 


 

Principal Investigator

Niloofar Dehghan, MD

Co-Investigator

Kreder Hans, MD, MPH, FRCS(C)

Grant Title

A Pilot Study of a Prospective Randomized Trial Comparing Early Post-Operative Motion and Weight-Bearing to Immobilization After Surgical Fixation of Bimalleolar Ankle Fractures

Grant Funded by

 


 Principal Investigator

E. Stephan Garcia, MD

Co-Investigator

Amr Abdelgawad, MD

Grant Title

Use of Local Free Antibiotic Powder in the Treatment of Osteomyelitis
Grant Funded by


Principal Investigator

Rachel Goldstein, MD, MPH

Co-Investigator

Nirmal Tejwani, MD

Grant Title

Efficacy of Popliteal Block in Post-operative Pain Management for Ankle Fractures. A Prospective Randomized Study

Grant Funded by


Principal Investigator

William Graham, MD

Co-Investigator

Thomas Ellis, MD

Grant Title

Acetabular Fracture after Total Hip Replacement

Grant Funded by


 

Principal Investigator

Jason Hsu, MD

Co-Investigator

Samir Mehta, MD

Grant Title

Oxygen Partial Pressure Monitoring in Impending Compartment Syndrome Associated with Diaphyseal Tibia Fractures

Grant Funded by


 

Principal Investigator

Lukas Nystrom, MD

Co-Investigator

Todd McKinley, MD

Grant Title

Accurate Radiographic Assessment of Pelvic Ring Fracture Deformity
Grant Funded by

 


 Principal Investigator

Kevin O'Neill, MD, MS

Co-Investigator

William Obremskey, MD, MPH

Grant Title

Quantitative Axial Micro-CT as a Surrogate for Biomechanics in a Mouse Fracture Model

Grant Funded by


 

Principal Investigator

Jaron Sullivan, MD

Co-Investigator

J. Lawrence Marsh, MD

Grant Title

Accurate Screw Placement for Calcaneus Fixation

Grant Funded by


 

Principal Investigator

John Tidwell, MD

Co-Investigator

David Hubbard, MD

Grant Title

The Effects of Melatonin on Fracture Healing in a Traumatic Femur Fracture Model


Grant Funded by


 

Principal Investigator

Lindley Wall, MD

Co-Investigator

Michael Gardner, MD

Grant Title

Volar Locking Plates for Extra-Articular Distal Radius Fractures: Is Unicortical Fixation Sufficient?

Grant Funded by


 

Principal Investigator

Akira Yamamoto, MD

Co-Investigator

Amir Matityahu, MD

Grant Title

Comparison of long versus short intramedullary hip nails for fixation of unstable intertrochanteric hip fractures: a cadaveric study

Grant Funded by

 


………………………………………………………………………………………………………………………………

 

 

2010

 

 

OTA 2010 GRANT AWARDS

 (Grant Cycle:  January 1, 2010 – December 31, 2010)

 

 

 

 

 

Directed Topic Clinical Study (up to $50,000/year, 3-year funding cycle)
(Proximal Humerus Fractures, Economic Outcomes in Trauma Care, Clinical Trial Re-evaluation of non-operative problems, Effect of non-operative post surgical therapy in trauma)

 

 

 

Title of Grant

Decreasing Long Term Complications and Cost Following Hip Fracture using a Medical Home Concept (MHC)

Principal Investigator  

Wade Smith           
Co-Principal Investigator

Jove Graham
Requested Funds

$97,785

                Presentations

                                None

                Publications

                                None

                Additional Awards and Grants

                                None

                New Product or Patent

                                None

                Pending Publications

                                OTA Abstract 2011 Annual Meeting, submitted February 2, 2011

                                Manuscript pending submission to JBJS, January 2012

                Project Status

                                Ongoing

 


 

 

 

Clinical Grants (up to $40,000/year, 2 year Grant Cycle)

 

 

 

Title of Grant

Multidisciplinary care of the geriatric patient with fractures below the hip

Principal Investigator

Gregory Della Rocca
Co-Principal Investigator

Yvonne Murtha
Requested Funds

$61,038

                Presentations

                                None

                Publications

                                None

                Additional Awards or Grants

                                None

                New Product or Patent

                                None

                Project Status

                                Ongoing

 


 

Title of Grant

 Prevalence of Abuse With An Intimate Partner Violence Surgical Evaluation (P.R.A.I.S.E.)
Principal Investigator

Brad Petrisor
Co-Principal Investigator

Mohit Bhandari
Requested Funds

$30,000

 


 

Title of Grant

Effects of the Presence of Microbial Biofilms on the Healing of Osseous Fractures Treated With Internal Fixation

Principal Investigator

Daniel Altman
Co-Principal Investigator

Greg Altman
Requested Funds

 $75,000 (note: requested $80,000)

 


 

 

 

 

Basic Research Grants (up to $25,000, 1 year Grant Cycle)

 

 

 

Title of Grant

Heterotopic Ossification in an Animal Extremity Blast Model
Principal Investigator

Robert O'Toole
Co-Principal Investigator

Vincent Pellegrini
Requested Funds

$25,000

                Presentations

                                Maryland Orthopaedic Association, May 2010

                                American British Canadian Research Fellow Meeting, May 2010

                                Orthopaedic Trauma Association Meeting, October 2010

                Publications

                                None

                Additional Award and Grants

                                Department of Defense Research Grant

                Amount Awarded

                                $600,000

                Funding Cycle

                                09/2010 – 09/2013

                New Product or Patent

                                None

                Pending Publications

                                The Journal of Orthopaedic Trauma, January 2011

                Project Status

                                Ongoing

 


 

Title of Grant

The Synergistic Effects of VEGF on BMP-induced Osteogenic Differentiation of Bone Marrow Stem Cells

Principal Investigator

Quanjun Cui
Co-Principal Investigator

Gary Balian
Requested Funds

$25,000 

 


 

Title of Grant

Engineering the Bioactivity of Absorbable Magnesium Implants for Fracture Fixation and Bone Defect Scaffolds:  The Effect of Calcium Phosphate Coatings on In-Vitro Biocorrosion and Osteogenic Differentiation of Mesenchymal Stem Cells.

Principal Investigator

Lawrence Bone
Co-Principal Investigator

Shuying Yang
Requested Funds

                                $25,000

Presentations

                National Association of Corrosion Engineers Conference – March 2011

                Society for Biomaterials Annual Meeting – April 2011

Publications 

                None

Project Status

Ongoing – Pending Publications:

Corrosion outcomes will be submitted to Biomaterials

Corrosion outcomes will be submitted to Biomaterials

Submitted

                                March 2011

May 2011

Additional Grants and Awards

R21 or R01 to NIAMS

Submitted

                                June 2011

Did this research grant lead to the development of a patent?

None

                Project Status

                                No

 



Title of Grant

Endothelial Progenitor Cells for Healing and Angiogenesis in a Segmental Bone Defect Model: A Comparison With Mesenchymal Stem Cells

 

Principal Investigator

Aaron Nauth
Co-Principal Investigator

Emil Schemitsch
Requested Funds

$25,000

 


 

Title of Grant

Preferential Peroneal Nerve Palsy after Posterior Hip Dislocation and Acetabular Surgery:   A Cadaveric Study

Principal Investigator

Ivan Tarkin
Co-Principal Investigator

Hans-Christoph Pape
Requested Funds

 $25,000      

                Presentations

                                None

                Publications

                                None

                Additional Awards or Grants

                                None

                New Product or Patent

                                None

                Project Status

                                Ongoing           

 

 

                                       

 

OTA 2010 RESIDENT $10,000 GRANT AWARDS

(Grant Cycle:  January 1, 2010 – December 31, 2010)

 

 

 

Title of Grant 

Chitosan-Mediated FGF18 Delivery for Assisted Bone Repair

Principal Investigator 

Alberto Carli, MD, C.M.
Co-Investigator

Edward J. Harvey, MD, CM


 

Title of Grant

The Efficacy and Cost Effectiveness of Preoperative and Postoperative Cryotherapy in Proximal Tibia Fractures

Principal Investigator 

Jesse Alan Shantz, MD MBA
Co-Investigator

David Sanders, MD

Presentations

                None

Publications

                None

Additional Grants and Awards

                OREF Orthopaedic Career Development Grant

 

Amount

                $50,000

Funding Cycle

                July 2010 – June 2011

New Product or Patent

                None

Pending Publications

  • Systematic Review of the Classification of Soft Tissue Injury in the Prospective Orthopedic Literature – Summer 2011
  • Evaluation of Soft Tissue Injury in Proximal Tibia Fractures and Knee Dislocations:  A Survey of the OTA and Knee Dislocations Study Group – Summer 2011
  • The Efficacy and Cost Effectiveness of Pre-operative and Post-operative Cryotherapy in Proximal Tibia Fractures – Summer 2012
  • The Development and Validation of a Novel Assessment Scale of Soft Tissue Injuries Associated with Proximal Tibia Fractures – Summer 2010

Project Status

                Ongoing


 

Title of Grant

Tension Tension Band Wiring of Patella Fractures Separating Fact from Fiction- A Biomechanical Study

Principal Investigator

Eric R Henderson, MD
Co-Investigator

 Henry Claude Sagi, M


 

Title of Grant

 Expression of single nucleotide polymorphisms in delayed fracture healing

Principal Investigator

Vikram M Sathyendra, MD
Co-Investigator

John S. Reid, MD

Presentations

                None

Publications

                None

Additional Grants and Awards

                None

New Product or Patent

                None

Pending Grants

                OTA Basic Research Grant

Submitted

                February 8, 2011

Project Status

                Ongoing


 

Title of Grant

                                The Effect of Low Magnitude Mechanical Signals on Tibial Shaft Fracture Healing

Principal Investigator

Roshan P Shah, MD, JD
Co-Investigator

Samir Mehta, MD


 

Title of Grant

The Comparison of the Therapeutic Potential of Isolated BMP-2 Producing Progenitor Cells, Bone Marrow Aspirates and Recombinant BMP-2 in Rodent Models of Bone Formation

Principal Investigator

 Brandon M. Steen, MD
Co-Investigator

 Thomas A. Einhorn, MD

Presentations:  

Marsell R, Bais M, Steen B, Mortlock D, Gerstenfel LC, Einhorn TA.  Skeletal Trauma Increases the Expression of Specific Mesenchymal Stem Cell Markers and Bone Morphogenetic Protein-2 in a Systemic Manner.  Orthopaedic Research Society Meeting – January 2010

Publications

 None

Additional Grants and Awards

Pending Grants – Submitted July 5, 2010. 

Project Title:  Role of Angiogenesis in    Distraction Osteogenesis Application Number:1 R01

 AR0566301  Pending percentile 13th.

Project Status

 2009 – Ongoing, 2010 – Ongoing

 


 

Title of Grant

Tension Band Fixation of the Medial Malleous using Fiberwire. Suture: A Biomechanical Study

Principal Investigator

Ty Fowler, MD
Co-Investigator

Kevin J. Pugh, MD
Presentations

                None

Publications 

Submitted for review

Additional Grants and Awards

                                 None

Project Status

 Ongoing – Currently submitted and under review for publication

Submitted

                                December 2010

 


 

Title of Grant

Locking Plate Fixation of Patella Fractures: A Biomechanical Study

Principal Investigator

Kristine E Banks, MD
Co-Investigator

Milan Sen, MD


 

 

 

 

 

 

 

 

 

 

………………………………………………………………………………………………………………………………

 

 

2009

 

 

OTA 2009 GRANT AWARDS

 (Grant Cycle:  January 1, 2009 – December 31, 2009)

 

 

 

 

 

Directed Topic Clinical Studies (up to $50,000/year, 3-year funding cycle)
(Proximal Humerus Fractures, Economic Outcomes in Trauma Care, Clinical Trial Re-evaluation of non-operative problems, Effect of non-operative post surgical therapy in trauma)

 

 

 

Title of Grant

Psychological Factors Predict Disability After Musculoskele Trauma                                                                  

Principal Investigator

Ana-Maria Vranceanu, PhD
Co-Principal Investigator

David Ring, MD, PhD

Awarded Grant

$80,000 (2-year)

Presentations 

ASSH – 2010

Preparing Abstract for OTA 2011
Publications 

None
Additional Grants and Awards

None

We are working on a collaboration with University of Amsterdam on a 2 sited CBT

intervention.  We are also searching for US agencies to fund our grant.
New Product or Patent

None

Project Status

                                Ongoing

 


 

Title of Grant

Early Psychiatric Intervention after Orthopaedic Trauma A Prospective, Randomized Double-Blinded Placebo Controlled Trial

Principal Investigator

Adam Starr, MD
Co-Principal Investigator

Joseph Borrelli, MD

Awarded Grant

 $148,806 (3-year)


 

Title of Grant

“Development and testing of a postoperative pain outcome tool for orthopaedic trauma surgery"

 

Principal Investigator

Kristin Archer, PhD            
Co-Principal Investigator

William Obremskey, MD, MPH                            
Amount and Date Funded

 $131,100 (3-year)                      
Presentations 

None
Publications 

Pain and Satisfaction in Hospitalized Trauma Patients

Development of a Multidimensional postoperative Pain Instrument

(MPPI) in Patients Following Traumatic Injury

                Submitted

                                 In preparation

Additional Grants and Awards

 None

New Product or Patent

None

                Project Status

                                Ongoing

 


 

Title of Grant

The role of Antibiotics in Open Fractures Revisited:  Characteristics of Staphylococcus Aureus and Susceptibility Profile

Principal Investigator

Carla Saveli, MD  Connie S. Price, MD
Co-Principal Investigator

Steven Morgan, MD              

Awarded Grant

$80,000 (2-year)

Presentations 

Surgical Infection Society

                Submitted

                                May 2011

Publications 

                None

                Project Status

                                Ongoing

 


 

 

Clinical Grants (up to $40,000/year, 2 year Grant Cycle)

 

 

 

Title of Grant

Operative and Non-Operative Scapular Body and Glenoid Neck Fracture Treatment Indications

Principal Investigator

Clifford Jones, MD
Co-Principal Investigator

Debra Sietsema, PhD

Awarded Grant

 $80,000 (5-year)

                Presentations

                                None

                Publications

                                None

                Additional Awards and Grants

                                None

               

New Product or Patent

                                None

                Pending Publications

Abstracts will be submitted for presentations and a paper for publication upon completion of study.

                Project Status

                                Ongoing

 


 

 

Basic Research Grants (up to $25,000, 1 year Grant Cycle)

 

 

 

Title of Grant

 Local Drug Delivery Systems for the Treatment of Infections
Principal Investigator

 Michael Bosse, MD
Co-Principal Investigator

 John Ellington, MD
Awarded Grant

 $24,200

Presentations 

None

                Publications 

                None

Additional Grants and Awards

Recently requested and were approved for a no cost extension. 

Project Status

                                Ongoing

 


 

Title of Grant

Acute Cartilage Damage Associated with Intraarticular Fractures
Principal Investigator

Yuki Tochigi, MD, PhD                        
Co-Investigator  

Todd McKinley, MD                                         
Amount and Date Funded

$25,000 - January 1, 2009 - December 31, 2009

Presentations

Meetings                                

  • Tochigi Y, Martin JA, Rudert MJ, McCabe D, Goreham-Voss CM, Buckwalter JA, Brown TD. Acute phase pathology of cartilage injury in human ankle intraarticular fractures. 55th Annual Meeting of the Orthopaedic Research Society, February 22–25, 2009,Las Vegas, Nevada. Abstract ID: ORS2009-2661, Poster Presentation #1078, Poster Session 25: Cartilage Impact Models.
  • Tochigi Y, Baer TE, Zhang P, Martin JA, Brown TD. A new insult technique for a large animal survival model of human intra-articular fracture. OARSI World Congress on Osteoarthritis 2009, September 10–13, 2009, Montreal, Quebec, Canada. Abstract Control #589, Poster Presentation.
  • Tochigi Y, Martin JA, Lehman A, Vaseenon T, Zhang P, Buckwalter JA, Brown TD. Acute-phase aggravation of chondrocyte death in human ankle intraarticular fractures. OARSI World Congress on Osteoarthritis 2009, September 10–13, 2009, Montreal, Quebec, Canada. Abstract Control #183, Poster Presentation.
  • Tochigi Y, Martin JA, Lehman A, McKinley TO, Buckwalter JA, Brown TD. Acute-phase aggravation of chondrocyte death in ankle intra-articular fractures. 2009 Orthopaedic Trauma Association Pre-Meeting Courses: Basic Science Focus Form, October 7–8, 2009,San Diego, California. Abstract #: 435, Final Program Paper #:  BSFF 11, Podium Presentation.
  • Tochigi Y, Baer TE, Zhang P, Martin JA, Brown TD. Development of a large survival animal model of human intraarticular fracture: A new technique to replicate cell-level cartilage pathology in the porcine hock in vivo. 56th Annual Meeting of the Orthopaedic Research Society, March 6–9, 2010,New Orleans, Louisiana. Abstract ID: ORS2010-2172. Paper #:355: Short Talk Session 12 Biology of Fracture Repair.
  • Tochigi Y, Buckwalter JA, Zhang P, Vaseenon T, Lehman AD, Martin JA, Brown TD. Distribution and progression of chondrocyte damage in human ankle intraarticular fractures. 56th Annual Meeting of the Orthopaedic Research Society, March 6–9, 2010, New Orleans, Louisiana. Abstract ID: ORS2010–2200. Poster #943: Session 25 Cartilage Matrix Degradation.
  • Zhang P, Tochigi Y, Sauter EE, Martin JA, Brown TD. Chondrocyte death cascade in fracture-damaged cartilage in a porcine whole-organ model. 56th Annual Meeting of the Orthopaedic Research Society, March 6–9, 2010,New Orleans, Louisiana. Abstract ID: ORS2010-2149. Poster #952: Session 25 Cartilage Matrix Degradation.

Publications

                                Yes
                Name of Publication                                   Month/Year                  Volume #

  • Tochigi Y, Baer TE, Zhang P, Martin JA, Brown TD. A new insult technique for a large animal survival model of human intra-articular fracture. Osteoarthritis Cartilage 2009;17 (Supp 1):S51–52.
  • Tochigi Y, Martin JA, Lehman A, Vaseenon T, Zhang P, Buckwalter JA, Brown TD. Acute-phase aggravation of chondrocyte death in human ankle intraarticular fractures. Osteoarthritis Cartilage 2009;17 (Supp 1):S112–113.

Did this research grant lead to the development of a larger grant and additional awards from other sources?

Yes            

Additional Grants and Awards                           
Title of Grant

Prompting Cartilage Stem Cell Activity to Improve Recovery From Joint Fracture
Funding Source

Department of the Army — USAMRAA
Project Dates

09/27/10-09/26/11
Total Project Costs

$143,753

Submitted

September 2009

Title of Grant

A Clinically Realistic Large Animal Model of Intra-Articular Fracture
Funding Source

Department of the Army — USAMRAA
Project Dates

09/15/10–09/14/13
Total Project Costs

$1,348,298

Submitted

November 2009

                Did this research grant lead to the development of a patent?

None

                Is this project concluded?

No

                If the project is not concluded, are additional publications and related grants expected?

Yes

Pending Publications

Tochigi  Y, Buckwalter JA,  Martin JA, Hillis SL, Zhang P, Vaseenon T, Lehman AD, Brown TD. Distribution and progression of chondrocyte damage in a whole organ model of human intra-articular fracture. J. Bone Joint Surg Am. ( in print)

Project Status

Ongoing

 


 

 

 

Classification Database and Outcomes Committee Pilot Project

 

 

 

Title of Grant

Development of Fracture Specific MFA Outcomes Scores - Pilot Project for Planning the
Major Investigation

Principal Investigator

Douglas W. Lundy, MD
Co-Principal Investigator

Julie Agel, MA
Awarded Grant

                $6,003

Presentations

                None

Publications

                None

Additional Awards and Grants

                None

New Product or Patent

                None

Project Status

                Ongoing

 


 

 

 

rhBMP-2 (up to $65,000/year, 2 - 3 year funding cycle)

**Basic**

 

 

 

Title of Grant

Combined Use of Recombinant Human Bone Morphogenetic Protein-2 and Low Intensity Pulsed Ultrasound in Orthopedic Traumatology

Principal Investigator

Amarjit Virdi, PhD
Co-Principal Investigator

Walter Virkus, MD
Awarded Grant

$129,709 (2-year)

                Project Status

                                Ongoing.  One year, no cost extension granted 01/24/2011

 

 

 

 

OTA 2009 RESIDENT $10,000 GRANT AWARDS

(Grant Cycle:  June 1, 2009 – May 31, 2010)

 

 

 

 

 

Title of Grant

Retropatellar Technique for Intramedullary Nailing of Tibia Fractures: A Prospective Evaluation

Principal Investigator

Jonathon G. Eastman, MD

Co-Investigator

Brad J. Yoo, MD

Grant Funded by

AO North America/OTA

Presentations

                                None

Publications

                None

Additional Grants and Awards

None

                New Product or Patent

                                None

Project Status

Ongoing

  


 

Title of Grant

Does Plugging unused screw holes increase the strength of locked compression plates in comminuted supracondylar femur fractures?

Principal Investigator 

Reza Firoozabadi, MD

Co-Investigator

Utku Kandemir, MD

Grant Funded by

AO North America/OTA

Presentations

                                Submitting to OTA

                Submitted

                                February 2011

Pending Publications

                Submitting to JBJS

                Submitted

                                March 2011

Additional Grants and Awards

None

                New Product or Patent

                                None

Project Status

Ongoing

 


 

Title of Grant

Immediate Weight Bearing of Comminuted Distal Femur Fractures Using Locked Plate Fixation: A Biomechanical Analysis

Principal Investigator

 Jaymes Granata, MD

Co-Investigator

 Thomas J.Ellis, MD

Grant Funded by

Foundation for Orthopaedic Trauma /OTA

 


 

 

 

Title of Grant

The Stability of the Postero-Medial Tibial Plateau Fracture Fragment Depends on Fragment Size, Knee Flexion Angle, and Applied Load

Principal Investigator 

 Igor Immerman, MD

Co-Investigator

 Kenneth A. Egol, MD

Grant Funded by

Foundation for Orthopaedic Trauma /OTA

Presentations

                                None

Pending Publications

                Expected at project completion

Additional Grants and Awards

None

                New Product or Patent

                                None

Project Status

Ongoing

 


 

Title of Grant

The effect of screw size on fatigue strength of fixation with statically locked Intramedullary Nails in Comminuted Femoral Shaft Fractures

Principal Investigator

Michael P. Kelly, MD

Co-Investigator 

Utku Kandemir, MD

Grant Funded by

Foundation for Orthopaedic Trauma /OTA

 


 

Title of Grant

The Effect of Repetitive Insertion On The Pullout Strength of Screws

Principal Investigator

Jeremiah Jonathan Maddox, MD

Co-Investigator

James P. Stannard, MD

Grant Funded by

OTA

 


 

Title of Grant

The effect of statin lipophilicity on bone fracture healing

Principal Investigator

Jason C. Phillips, MD

Co-Investigator 

 James S. Raphael, MD

Grant Funded by

 


 

Title of Grant

Preliminary study to identify osteoblastic cells in the peripheral circulation in mice.

Principal Investigator

Brian A. Silvia, MD,PhD
Co-Investigator 

Thomas Goss, MD

Grant Funded by

 OTA

 


 

Title of Grant

Quantitative Assessment of Osteogenic Genes and Proteins from Alternate Bone-
Graft Harvesting Sites.

Principal Investigator

Richelle Carrie Takemoto, MD

Co-Investigator 

 Kenneth A. Egol, MD

Grant Funded by

OTA

 


 

Title of Grant

Osteotropic Peptides: Therapy for Post-traumatic Osteonecrosis of the Femoral Head

Principal Investigator

Sarah R. Zawodny, MD

Co-Investigator 

Quanjun Cui, MD
Grant Funded by

OTA


 

OTA 2009 RESIDENT $10,000 GRANT AWARDS

(Grant Cycle:  January 1, 2009 – December 31, 2009)

 

 

 

Title of Grant

Harnessing Collective Intelligence for the Management of Subcapital Hip Fractures

Principal Investigator 

Jaimo Ahn, MD, PhD                              
Co-Investigator 

Joseph Bernstein, MD, MS
Amount Funded

$10,000
Presentations
Publications
Additional Grants and Awards
Project Status

 


 

Title of Grant
                Inflammatory Response to Trauma in the Obese
Principal Investigator

Arun Aneja, MD         
Co-Investigator

George Russell, MD                              
Amount and Date Funded:
             $10,000                            
Presentations
                Mississippi Orthopaedic Society - May 2010
Publications 

Induced Pulmonary Injury in the Obese Zucker Rat; Orthopaedic Trauma; 11/17/10, doi:10.1111/j.1549-8719.2010.00061.x.

Additional Grants and Awards

Yes

                Grant Title

AONA Kathryn Cramer Memorial

Amount Award

$14,800.00

Funding Cycle

06/15/2010-06/14/2011

Grant Title
                Mississippi Institute of Minority Health

Amount Awarded

$5,000

Funding Cycle

5/09-5/10

New Product or Patent

                None

Pending Publications

Microcirculation Journal - awaiting results/date s

Submitted

March 2010
Project Status

Ongoing

               


 

Title of Grant

                                Measurement of Tissue Oxygenation for Diagnosis of Acute Compartment Syndrome f                                   following Tibia Fracture A Pilot Study

Principal Investigator 

 Erik Hansen, MD                            

                Amount Funded

 $10,000
Co-Investigator 

Utku Kandemir, MD


 

Title of Grant

Osteogenic Cell Viability in Bone Graft Obtained in Reamer Irrigator and Aspirator (RIA) System Versus Iliac Crest Bone Graft

Principal Investigator

Raj Kakarlapudi, MD                  

Amount Funded

 $10,000
Co-Investigator

Brett Crist, MD

                Presentations

                                Mid-America Orthopaedic Association Annual Meeting

                Submitted

                                April 2011

                Publications

                                None

Additional Grants and Awards

                                AO North America Resident Research Award

                Amount Awarded

                                $5,000.00

                Funding Cycle

                                2008-2009

                New Product or Patent

                                None

                Pending Publications

                                Manuscript expected once larger sample size is completed

                Project Status

                                Ongoing

                               


 

Title of Grant

The effects of suramin treatment on fracture healing and muscle regeneration in a rodent model

Principal Investigator 

Ethan Kellum, MD, MS                      

Amount Funded

 $10,000
Co-Investigator

Michael Tucker, MD/


 

Title of Grant

Foreign-body Induced  Biomembranes  in Segmental Bone Defects: Histologic, Immunohistochemical, and Gene Expression Properties in a Rat Model

Principal Investigator

James Starman, MD                            

Amount Funded

 $10,000
Co-Investigator

Michael Bosse, MD

                Presentations

                                None

                Publications

                                None     

Additional Grants and Awards

                                None

                New Product or Patent

                                None

                Project Status

Concluded – We are in the process of writing a manuscript.  Additional Abstract submissions to The Association of Bone and Joint Surgeons 63rd Annual Meeting and the 2011 Orthopaedic Trauma Association Annual Meeting are pending.  We expect a manuscript to be completed in the next two to three months.


 

Title of Grant

Effect of Mesenchymal Stem Cell-Based Gene Transfer of VEGF and eNOS on Healing  of a Segmental Bone Defect

Principal Investigator 

Aaron Nauth, MD                         

Amount Funded

 $10,000
Co-Investigator 

Emil Schemitsch, MD FRCSC

                Presentations

                                Orthopaedic Trauma Association Annual Meeting – October 2009

                                Orthopaedic Research Society Annual Meeting – March 2010

                                AmericanAcademy or Orthopaedic Surgery – March 2010

                Publications

                                Journal of Orthopaedic Trauma; March 2010; 24:S17-24

                                Journal of Orthopaedic Trauma; September 2010; 24(9):547-53

Additional Grants and Awards

                                PSIF Resident Grant

                Amount Awarded

                                $25,000.00

                Funding Cycle

                                2009-2010

Additional Grants and Awards

                                Cihr Banting and Best Master’s Award

                Amount Awarded

                                $18,500.00

                Funding Cycle

                                2009-2010

                New Product or Patent

                                None

                Project Status

                                Concluded


 

Title of Grant

                                Vacuum assisted closure of acetabular fracture incisional wounds in the obese.

Principal Investigator

Matthew Futvoye, MD                     

 Amount Funded

$10,000
Co-Investigator

George Russell, MD

 


 

Title of Grant

Sterility of Intraoperative Irrigation

Principal Investigator

Thomas Jones, MD                     

Amount Funded

 $10,000
Co-Investigator 

Laura Prokuski, MD


 

Title of Grant

Characterization of the Interface between Neocartilage Produced by Nonarticular Chondrocytes and the Subchondral Bone

Principal Investigator 

Tamara Pylawka, MD                  

Amount Funded

 $10,000
Co-Investigator

Spence Reid, MD

 


 

 

 

 

 

 

 

 

 

………………………………………………………………………………………………………………………………

 

2008

 

 

OTA 2008 GRANT AWARDS

 (Grant Cycle:  January 1, 2008 – December 31, 2008)

 

 

 

 

Clinical Grants (up to $40,000/year, 2 year grant cycle)

 

 

 

Title of Grant
                “A Multicenter Randomized Clinical Trial of Non-operative versus Operative Treatment of
                High-grade, Acute Acromio-clavicular Joint Dislocation”
Grant Funded by

OTA/Synthes

Principal Investigator

Michael McKee, MD, FRCS(C)              

Co-Investigator

Guy Pierre, MD, FRCS(C)                                

Amount and Date Funded: 

$50,000    (3-year grant cycle)                          
Presentations

                                None

Publications

                None

Additional Grants and Awards

OTC Grant

                Amount Awarded

                                $50,000 ($25,000/year)

                Funding Cycle

                                2008 (2 year cycle)

Project Status

Ongoing

We have reached our sample size and enrollment has concluded.  We are quite satisfied with the quality of data collected thus far, however, data collection is ongoing.  We expect to have an abstract prepared to be submitted in 2012, once we obtain the 2 year follow-up for all enrolled subjects.

 


 

 

Title of Grant
                “Cerebrospinal Fluid Cytokines as Biomarkers for Delirium Following Hip Fracture Repair

                in Elders” 

Grant Funded by

 OTA/Stryker Orthopaedics

Principal Investigator

 Simon Mears, MD, PhD                           

Co-Investigator

 Ronald Byank, MD                                             

Amount and Date Funded
                 $39,620  (year 1: $19,810 – year 2: $19,810)                    
Presentations

                                None

Publications

                                None

Additional Grants and Awards

None                      

Project Status

Ongoing

 


 

Title of Grant

“Intramedullary Nails versus Plate Fixation Re-Evaluation Study in Proximal Tibia Fractures:  A Multicenter Rando mized Trial Comparing  IM Nails and Plate Fixation (IMPRESS)” 

Grant Funded by

OTA/Orthofix
Principal Investigator

Paul Tornetta, MD                                 

                Amount Funded

$80,000

Co-Investigator

Andrew Schmidt, MD                                         (year 1: $39,500 – year 2: $40,500)

                Presentations

                                None

                Publications

                                None

                Additional Awards and Grants

                                None

                New Project or Patent

                                None

                Project Status

                                Ongoing

  


 

Title of Grant
                “A Study of Locked Plates versus Intramedullary Nails in Distal Femur Fractures:
                A Multicenter Randomized Trial Comparing IM Nails and Plate Fixation (SOLVED)”
Grant Funded by

                                OTA/AO North America & Smith and Nephew              

Principal Investigator

Paul Tornetta, MD                 

                Amount Funded

$80,000
Co-Investigator

William Ricci, MD                                             (year 1: $39,500 – year 2: $40,500) 

                Presentations

                                None

                Publications

                                None

                Additional Grants and Awards

                                None

                New Product or Patent

                                None

                Project Status

                                Ongoing

 


 

 

 

 

 

rhBMP-2 ($65,000/year, 2 - 3 year funding cycle)

 

 

 

Title of Grant
                “RhBMP2 vs. Autograft for Critical Size Tibial Defects: A multi-center randomized trial”
Grant Funded by

OTA/Medtronic

Principal Investigator

 Lisa Cannada, MD                        

Co-Investigator

 Paul Tornetta, MD (2-year grant cycle)             

 Amount and Date Funded
 $63,494

Presentations

None

Publications

                 None

Additional Grants and Awards

Yes

Grant Title

RhBMP2 vs. Autograft for critical Size Tibial Defects:  A multi-center randomized trail funded by the Department of Defense as part of the Major Extremity Trauma Research Consortiu.

Amount Funded

$1.2 million

Grant Cycle

2010-2013

                New Product or Patent

                                None

Project Status

                                Ongoing

 


 

 

 

Basic Research Grants (up to $25,000, 1 year grant cycle)

 

 

 

Title of Grant

“Objective Assessment of Fracture-Associated Soft Tissue Injury Using CT-Based Texture Analysis”

Grant Funded by

OTA/AO North America

Principal Investigator
                Donald Anderson, PhD        

Co-Investigator

                 J. Lawrence Marsh, MD

Amount and Date Funded
                $25,000                              
Presentations

54th  Annual Meeting of the Orthopaedic Research Society - San Francisco, CA - March 2-5, 2008
75th Annual Meeting of the AAOS - San Francisco, CA  - March 5-9, 2009
OARS! World Congress on Osteoarthritis 2008 - Rome, Italy - September 2008
55th Annual Meeting of the Orthopaedic Research Society - Las Vegas, NV - February 22-25, 2009

Publications

                                Osteoarthritis and Cartilage - September 2008; 16(Supp 4)

Additional Grants and Awards

Pending grant - Army/PRORP Hypothesis Development Award/Sept. 15, 2009 submitted.

 

Project Status

                                Concluded

 


 

Title of Grant
                                “Trans-sacral/Alar Screw Fixation for Comminuted Transforaminal Sacral Fractures” 

Grant Funded by

OTA/Biomet Trauma
Principal Investigator

Brett Crist, MD                                      

                Amount Funded

 $25,000

Co-Investigator

Gregory Della Rocca, MD, PhD

                Presentations

                                OTA Annual Meeting – Basic Science Forum – October 2010

AO North America – 2010 challenges in Fracture Care across Disciplines – November 2010

                                Orthopaedic Research Society – Annual Meeting 0 January 2011

                                AAOS Annual Meeting – February 2011

                Publications

                                None

                Additional Grants and Awards

                                None

                New Product or Patent

                                None

                Pending Publications

Manuscript submitted as part of OTA Basic Science Forum for Journal of Orthopaedic Trauma – September 2010

                Project Status

                                Ongoing

 


 

Title of Grant
                                “Real-Time In Vivo Profiling of Vascular Endothelial Growth Factor Receptor 2 Expression
                                During Bone Healing in Living Mice” 

Grant Funded by

OTA/Biomet Trauma

Principal Investigator

Philipp Mayer-Kuckuk, PhD              

Amount Funded

$25,000

Co-Investigator

 Joseph Lane, MD

 


 

Title of Grant
                                “Efficacy and Safety of Covalently Bonded Silver External Fixation Pins” 

Grant Funded by

OTA/Stryker Orthopaedics

Principal Investigator

Greg Merrell, MD                 

Amount Funded

 $25,000

Co-Investigator

 Michael Medvecky, MD

                Presentations

                                None

                Publications

                                None

Additional Grants and Awards

Canadian IRAP Grant

Additional Grant Amount

$230,000

Funding Cycle

2010

New Product or patent

Antibiotic coated orthopaedic implants are being developed but have yet to reach commercial production.

Pending Publications

A manuscript is in preparation

                Project Status

                                Ongoing

                  

 

 

OTA 2008 RESIDENT $10,000 GRANT AWARDS

(Grant Cycle:  January 1, 2008 – December 31, 2008)

 

 

 

Title of Grant
                Antibiotic Prophylaxis in Orthopaedic Traumatology: A Prospective, Randomized Trial of

Duration of Administration 

Grant Funded by

OTA/FOT

Principal Investigator

David Greenberg, MD          

Co-Investigator

Brett Crist, MD   

Amount Funded
             $10,000   

Date Funded

January 2008
Presentations

None
Additional Grants and Awards

                                None

Project Status
                                2008-Extension approved. 
                                2009 - Data collection is ongoing. Anticipation of 1-2 years prior to completion.

 


 

Title of Grant

Analysis of Long Bong Fracture Nonunion by an expression profile of the Matrix Metalloproteinases and ADAMTS enzyme families: a prospective study 

                Principal Investigator

Marc Fajardo, MD                                     

Amount Funded

$10,000

Co-Investigator

Kenneth Egol, MD

Grant Funded by

OTA/FOT

                Presentations

                                Medical Society of New York Annual Meeting – 2008

                                ATA Annual Meeting – 2008

                                AAOS Annual Meeting – 2009

                                AREF Annual Research Symposium – NY – 2008

                                ASBMR Annual Meeting – 2008

                Publications

Fajardo M, Liu CJ, Ilalov, K, Egol, K; Matrix metalloproteinases that associate with and cleave bone morphogenetic protein-2 in vitro are el3vated in hypertrophic fracture nonunion tissue. Journal of Orthopaedic Trauma; 2010 Sept 24(9):557-63

                Additional Grants and Awards

                                None

                New Product or Patent

                                None

                Project Status

                                Concluded

 


 

 

Title of Grant

Axial CT Evaluation of the Distal Tibiofibular Syndesmosis 

Grant Funded by

OTA/FOTA

Principal Investigator

Gregory Dikos, M.D

Co-Investigator

Timothy Weber, M.D

Amount and Date Funded
             $10,000                                    January 1, 2008 - December 31, 2008
Presentations

32nd Annual Garceau-Wray Lectureship     June 2008 - IndianaUniversitySchool of Medicine
25th Annual OTA Meeting    Poster - October 2009 - San Diego, California

Publications

                                None 

Additional Grants and Awards

                                 Methodist Research Institute Grant - $10,000 Funding Cycle: 1/1/2008 - 12/31/2008
                                IndianaUniversity Foundation Grant - $2,000  Funding Cycle: 1/1/2008 - 12/31/2008

                New Product or Patent

                                None

Pending Publications

                                JBJS. 

Submitted

June 2010.  Awaiting final decision.

Project Status
                                Concluded

 


 

 

Title of Grant

Does Leptin Modulate Fracture Healing After Traumatic Brain Injury? 

Principal Investigator

Safdar Khan, MD

Amount Funded

 $10,000

Co-Investigator

Mark Lee, MD        

Grant Funded by

OTA/FOT

 


 

 

Title of Grant

Effects of FGF-2 and BMP-7 on articular injuries in rabbits 

Principal Investigator

 Alexis Dang, MD                  

Amount Funded

 $10,000

Co-Investigator

Theodore Miclau, MD          

Grant Funded by

 OTA/FOT

 


 

Title of Grant
                                ”Ultrasound for the Use of Predicting Union After Tibia Fractures Treated with Reamed

Intramedullary Interlocked Nails
Grant Funded by

OTA/Medtronic
Principal Investigator   

Adam Rana, MD

Co-Investigator

Paul Tornetta, MD

Amount and Date Funded
                $10,000                                    January 1, 2008 - December 31, 2008
Presentations

OTA Annual Meeting, 25th Anniversary Meeting, San Diego - Oct. 8-10, 2009

OTA Annual Meeting – November 2010

Publications

                None

Additional Grants and Awards

None

                New Products or Patents

                                None

                Pending Publications

Journal of Orthopaedic Trauma

                Submitted

                                February 1, 2011

Project Status

Concluded

 


 

 

Title of Grant

The effect of nitric oxide on intramedullary vascularity and fracture healing 

Principal Investigator

James Meeker, M.D          

 Amount Funded

$10,000

Co-Investigator

Laurence Dahners, M.D.    

Grant Funded by

 OTA/Medtronic

 


 

Title of Grant

The Effects of Hypothermia and Mediators on Skeletal Muscle Function Following
Ischemia-Reperfusion Injury 

Principal Investigator

 Daniel Stahl, MD                                    

 

Co-Investigator

Robert Probe, MD
Grant Funded by

OTA/Medtronic

Amount and Date Funded:
             $10,000                                    January 1, 2008 - December 31, 2008
Presentations

                                OTA Annual Meeting, October 2010

Publications

                                None

Additional Grants and Awards

                                None

                New Product or Patent

                                None

                Pending Publications

                                Submitted to Journal of Orthopaedic Trauma, January 2011

Project Status
                                Concluded, 2009

 


 

Title of Grant

Effect of Timing of Indomethacin Administration on Cell Damage due to Elevated
Compartment Pressure: An Intravital Videomicroscopy
Study in Rats 

Principal Investigator

Ajay Manjoo, MD                              

                Amount Funded

$10,000

Co-Investigator

                                David Sanders, MD              

Grant Funded by

OTA/Medtronic

 


 

Title of Grant

The Mechanism for Chondrocyte Apoptosis Following Mechanical Injury 

                Principal Investigator

                                Eric Eisner, MD                          

               Amount Funded

$10,000

Co-Investigator

 Joseph Borrelli, MD             

Grant Funded by

OTA/AO North America

 


 

Title of Grant

The Use of Bone Marrow-Derived Mesenchymal Stem Cells in the Prevention and Treatment of a Rat Atropic Nonunion Model 

Principal Investigator

Susan Tseng, MD                

               Amount Funded

$10,000

Co-Investigator

Mark Lee, MD        

Grant Funded by

OTA/AO North America

 


 

Title of Grant

Medial vs. Anterolateral Plating of Extraarticular Distal Tibial Fractures (AO/OTA 43A):

A Biomechanical Analysis 

Principal Investigator

Aaron Chamberlain, MD                         

Amount Funded

$10,000

Co-Investigator

Robert Dunbar, MD             

Grant Funded by

OTA/Smith & Nephew Orthopaedics

 


 

Title of Grant

Comparison of short and long Cephalomedullary nail in treatment of unstable
intertrochanteric hip fractures-Biomechanical study 

Principal Investigator

                Mark Stouffer, MD

 Amount Funded

 $10,000

Co-Investigator

Michael Prayson, MD          

Grant Funded by

OTA/Smith & Nephew Orthopaedics

 

 

 

 

 

OTA 2008 RESIDENT $10,000 GRANT AWARDS

(Grant Cycle:  June 1, 2008 – May 31, 2009)

 

 

 

Title of Grant

 Effect of Tibial Plateau Fracture on Synovial Fluid Lubrication Function and Constituents

Principal Investigator

 Brooke Ballard, M.D.

Amount Funded

$10,000

Co-Investigator

                                Alexandra Schwartz, M.D.

Grant Funded by

 OTA/AO North America

                Presentations

                                Ruth Jackson Research Resident Presentation, February 2009

                                OREF Research Presentation, May 2008

Publications

                None

Additional Grants and Awards

                NIH

New Product or Patent

                None

Pending Publications

                Effect of Tibial Plateau Fracture on Lubrication Function and Composition of Synovial

Fluid.

                Submitted

                                December 31, 2010

                Project Status

                                Ongoing

               


 

 

Title of Grant 

Can the Use of Polyaxial Distal Radius Locking Plates Compensate for Suboptimal Plate Position?

Principal Investigator

James Halloran, MD Melissa Collins, MD

Amount Funded

 $10,000             

Co-Investigator

  Edward Harvey, MSc, MD, FRCSC

Grant Funded by

OTA/AO North America

                Presentations

                                McGill Orthopaedic Resident Research Day

                Submitted

                                April 2009

                Publications

                                None

                Additional Grants

                                None

                New Product or Patent

                                None

                Pending Publications

                                Will be submitted when completed

                Project Status

                                Ongoing – Further material has been obtained at our expense to completed project.

 


 

Title of Grant
                                  Ulnar Neck Fractures: A Biomechanical Study

Grant Funded by

 OTA/AO North America

Principal Investigator
                                Jerod Hines, MD     

Co-Investigator

                                Max Talbot, MD, FRCS

Amount and Date Funded
                $10,000                              
Presentations

                                None

Publications

                                None

Additional Grants and Awards   

                None             

Project Status

                                Ongoing.  2009 update: Awaiting the hardware for testing.

 


 

 

Title of Grant

 Acceleration of Fracture Healing by Novel Polypeptides

Principal Investigator

 Kyle Kokko, MD, PhD                               

Amount Funded

 $10,000 

Co-Investigator 

 Langdon Hartsock, MD
Grant Funded by

OTA/AO North America

 


 

 

Title of Grant

A Prospective Evaluation of Brain Oxygenation and Neurologic Outcomes After Intramedullary Nailing in Patients with Long Bone Fractures and Head Injury.

Principal Investigator

 J. Stuart Melvin, MD

Amount Funded

 $10,000

Co-Investigator

  Samir Mehta, MD

Grant Funded by

 OTA/AO North America

                Presentations

                                None

                Publications

                                None

                Additional Grants

                                None

                New Product or Patent

                                None

                Project Status

                                Ongoing

 


 

 

Title of Grant

                                Role of PAR-2 in Fracture Healing

Principal Investigator

 Jonathan Schoenecker, MD, PhD

Amount Funded

 $10,000

Co-Investigator

  William Obremskey, MD, MPH
Grant Funded by

 OTA/AO North America

 


 

Title of Grant
                                 Efficacy and Dose Evaluation of TPO in Healing Critical-Sized Femoral Defects

Grant Funded by

OTA/AO North America

Principal Investigator
                                Jonathan Wilhite, MD   

Co-Investigator

Jeffrey Anglen, MD

Amount and Date Funded
                $10,000                              
Presentations

IndianaUniversitySchool of Medicine, Department of Orthopaedic Surgery Garceau-Wray Lectureship – June 2010

Indiana Orthopaedic Society (scheduled) – May 2011

Publications

                                None

Additional Grants and Awards

NIH R21 or R01 anticipated (Date submitted 10/2010)

                Pending Grants

                                Critical-sized defect regeneration using thrombopoietin-loaded scaffolds. 

Anticipated resubmission date:  03/16/2011.

Developing load-bearing biodegradable scaffold for mouse segmental defect models.  Anticipated submission date:  02/25/2011.

                New Product or Patent

US provisional patent on the invention June 3, 2010 (IURTC Tech No. 10099).  “Bone Healing by a novel compound.”

               Project Status

Completed

………………………………………………………………………………………………………………………………

 

2007

 

 

OTA 2007 GRANT AWARDS

 (Grant Cycle:  January 1, 2007 – December 31, 2007)

 

 

 

 

Clinical Grant Applications (up to $40,000/year, 2 year grant cycle)

 

 

 

Title of Grant
                                “Dynamic Hip Screw vs. Trochanteric Fixation Nail in the Treatment of Intertrochanteric
                                Hip Fractures”

Grant Funded by

 OTA/DePuy, a Johnson & Johnson Company

Principal Investigator

 Rudolph Reindl, MD

Co-Investigator

  Edward J. Harvey, MD         

Amount and Date Funded
                $80,000 (2-year grant)                                 ($40,000 - 2007, $40,000 - 2008)
Presentations

Canadian Orthopaedic Association Meeting, Quebec City - June 2008
                (Results of pilot study).
Publications

 None

Additional Grants and Awards

2007 Synthes Research Grant
Amount Awarded - $20,000.00  
2008 Synthes Research Grant
Amount Awarded - $20,000.00     

Project Status
                                2008-Ongoing

 


 

Title of Grant

“A Prospective Randomized Trial Comparing Open Reduction and Internal Fixation, Non-Spanning External Fixation, and Closed Reduction with Percutaneous Fixation in Displaced   Distal Radius Fractures with Joint Congruity”

Grant Funded by

 OTA/Zimmer

Principal Investigator

 Gregory K. Berry, MD
Co-Investigator

 Hans J. Kreder, MD             

Amount and Date Funded:
                $80,000 (2-year grant)                                         ($40,000 - 2007, $40,000 - 2008)
Presentations

                                Boston OTA/COTS (Update)                                                             Oct. 2007
                                Quebec OTA/COTS (Update)                                                            June 2008
                                Quebec OCCG (Update)                                                                    June 2008

                                Canadian Orthopaedic Trauma Society – Edmonton, AB          June 2010

                                Canadian Orthopaedic Trauma Society – Baltimore, MD           October 2010

Publications

None

Additional Grants and Awards

                                None

                New Product or Patent

                                None

Project Status

                                2008-Ongoing and is now multi-study.  Six out of eight centers actively recruiting.

Extension requested.  Completion of patient enrollment in 2010, one year later than

foreseen.

 


 

Title of Grant
                                 “Outcomes of Femur Fractures: RIA versus Standard Reaming”

Grant Funded by

 OTA/Biomet Trauma

Principal Investigator
                                Kyle J. Jeray, MD           

Co-Investigator

                                J. Scott Broderick, MD  

Amount and Date Funded:
                $80,000                                    $40,000 - 2007, $40,000 – 2008 (2 year Grant)
Presentations

                                None at this time

Publications

None at this time
Additional Grants and Awards

Synthes supply grant.  In process of obtaining additional funding to hire Clinical Research Assistant.

Project Status

2008 - Ongoing, open and actively enrolling patients.  Currently 45 patients enrolled. This grant is currently funding a multi-center study entitled “Standard Reaming versus Reaming/Irrigating/Aspirating for Intramedullary Nailing of Femoral Shaft Fractures (S.T.A.F.F.).

 


 

 

 

Directed Topic Clinical Study: (up to $50,000/year, 3 year funding cycle)

 

 

 

Title of Grant

“Timing of Orthopaedic Surgery in the Multiply-injured Patient: Development of a
Protocol for Early Appropriate Care”

Grant Funded by

 OTA/Smith & Nephew/Medtronic
Principal Investigator

 Heather A. Vallier, MD              

Amount Funded

 $150,000 (3-year grant)

Co-Investigator

John Howard Wilber, MD

                Amount and Date Funded

$150,000 – 3 year grant                                     $50,000/yr 2007-2009

Presentations

OTA Annual Meeting, October 2008
AAOS Annual Meeting, February 2009

OTA Annual Meeting – October 2010

OTA Annual Meeting – October 2010

OTA Annual Meeting (Poster) – October 2010

Publications

 

            Name of Publication                                   Month/Year                  Volume #

  • Vallier HA, Cureton BA, Eckstein C, Oldenburg FP, Wilber JH.  Early definitive stabilization of unstable pelvis and acetabulum fractures reduces morbidity, Journal of Trauma.  69:677-684, 2010
  • Nahm N, Como JJ, Wilber JH, Vallier HA.  Early appropriate care: definitive stabilization of femoral fractures within 24 hours is safe in most multiply-injured patients, Journal of Trauma, in press, 2010.
  • Vallier HA, Super DM, Moore TA, Wilber JH.  Do patients with multiple system injury benefit from early fixation of unstable axial fractures?  The effects of timing of surgery on initial hospital course.  Journal of Orthopaedic Trauma, submitted for publication, 2010.
  • Multiple other publications are anticipated.

Additional Grants and Awards

                Submitted, unfunded:

  • Timing of Orthopaedic Surgery in the Multiply-Injured Patient: A Prospective Protocol for Early Appropriate Care of unstable fractures of the pelvis and femur.  OREF 2008
  • Timing of Orthopaedic Surgery in the Multiply-Injured Patient: A Prospective Protocol for Early Appropriate Care of unstable fractures of the pelvis and femur.  NIH 2009
  • Timing of Orthopaedic Surgery in the Multiply-Injured Patient: A Prospective Protocol for Early Appropriate Care of unstable fractures of the pelvis and femur.  OREF 2010

Submitted, pending:

  • Timing of Orthopaedic Surgery in the Multiply-Injured Patient: A Prospective Protocol for Early Appropriate Care of unstable fractures of the pelvis and femur.  NIH 2011

New Product or Patent

                None

Project Status
                                2008-Ongoing

 


 

 

 

Basic Research Grants (up to $25,000, 1 year grant cycle)

 

 

 

Title of Grant

“Can we eliminate the need for autologous bone graft harvest for fracture management? 
The use of multipotential adipose derived stromal cells in an activated matrix
for in vivo osteogenesis”

Grant Funded by

 OTA/Synthes, USA

Principal Investigator

 Francis H. Shen, MD

Co-Investigator

 Shepard R. Hurwitz, MD

Amount and Date Funded:
                $25,000                                                    January 2007
Presentations

                                International Society for the Study of the Lumbar Spine, June 2007

                                Sixth Combined Meeting of the Orthopaedic Research Society, October 2007

Publications

2008- Pending Publication, A Novel Reproducible Animal Model Simulation Vertebral Body Defect Repair  

Additional Grants and Awards

                                National Osteoporosis Foundation- $50,000, July 2007-June 2008

Project Status
                                2008-Ongoing

 


 

Title of Grant
             “Effect of Delayed Surgery on Infection Rate of Open Fractures in a Rabbit Model”

Grant Funded by

 OTA/Stryker Orthopaedics

Principal Investigator

 Langdon A. Hartsock, MD                      

Amount Funded

$25,000

Co-Investigator

 Yuehuei An            

Amount and Date Funded
                $25,0000                                                  January 2007
Presentations

                                Southern Orthopaedic Association – February 2008
                                South Carolina Orthopaedic Association – July 2008
                                MUSC Orthopaedic Siegling Society Research Day    - April 2008

Publications

                                Pending – Journal of Orthopaedic Trauma (plans to submit)

Additional Grants and Awards

                                NIH ROI  (not submitted yet)

Project Status
                                2008 – Project complete.  Plans to submit future grant application for additional           

                                research.

 


 

 

Title of Grant
                “Effects of rhBMP-7 on Fracture Healing in an Ischemic Environment”
Grant Funded by

 OTA/AO North America
Principal Investigator

 Chuanyong Lu, MD  

Co-Investigator

Theodore Miclau, III MD     

Amount and Date Funded:
             $25,000                                    January 2007
Presentations

                                ORS 54th Annual Meeting, March 2008

                                OTA Annual Meeting, October 2008

                                ORS 55th Annual Meeting, February 2009

                                OTA Annual Meeting, October 2009 (other work supported by the grant)

                                ORS 56th Annual Meeting, March 2010 (other work supported by the grant)

                                OTA Annual Meeting, October 2010 (other work supported by the grant)

Publications

                                Journal of Orthopaedic Research; May 2010; 28(5)

                                Journal of Orthopaedic Trauma; 2011; Invited paper

Additional Grants and Awards

                None

New Product or Patent

                None

Project Status
                                Concluded

 


 

Title of Grant

“Segmental Defect Regeneration Using Biodegradable Load-Bearing BMP-2
Carriers in a Canine Model”

Grant Funded by

 OTA/Medtronic
Principal Investigator

 Rena L. Stewart, MD

Co-Investigator

Tien-Min Chu

Amount and Date Funded:
                $25,000                    January 2007
Presentations

                                Orthopaedic Research Society Meeting- March 2008

                                Combined AOA/COA Meeting- June 2008

                                OTA Annual Meeting- October 2008

Publications

                                Will be submitted fall 2008 for publication to the Journal of Trauma

Additional Grants and Awards

                                OREF/Zimmer Career Development Grant- $50,000 (2008-2009)

Project Status
                                2008- Project Completed

 

 

 

 

OTA 2007 RESIDENT $10,000 GRANT AWARDS

(Grant Cycle:  June 1, 2007 – May 31, 2008)

 

 

 

Title of Grant
                                “The Role of Sensory Nerve Function and Fracture Healing”

Grant Funded by

 OTA

Principal Investigator

 Peter Apel, MD          

Co-Investigator  

Robert Teasdall, MD

Amount and Date Funded:
                $10,000                                    June 2007
Presentations

                None

Additional Grants and Awards        

                None 

Project Status
                                Concluded 

 


 

Title of Grant
            “The Use of Osteogenic BMPs to Augment Healing of Critical Sized Femoral Defects in a

Rat Model”

Grant Funded by

OTA

Principal Investigator

Matthew Beal, MD

Co-Investigator

                                Michael Stover, MD

Amount and Date Funded:
                $10,000                                     June 2007
Presentations

None
Publications

None
Additional Grants and Awards

                                None

Project Status
                                2008-Ongoing/Extension approved.

 


 

Title of Grant
                                “Cytokine liberation from secondary surgery in the setting of the second hit syndrome”

Grant Funded by

OTA

Principal Investigator

Reed Estes, MD       

Co-Investigator

David Volgas, MD

Amount and Date Funded:
                $10,000                                        June  2007
Presentations

None
Publications

                                Pending submission to JOT

Additional Grants and Awards

                                None

Project Status
                                2008- Ongoing/Extension approved.
                                2009 - Completed

 


 

Title of Grant
                                “Correlation of Health Outcome Measure Scores in Foot and Ankle Trauma”

Grant Funded by

 OTA

Principal Investigator

Christina Goldstein, MD          

Co-Investigator

Bradley Petrisor, FRCSC

Amount and Date Funded
                $10,000                                      June 1, 2007
Presentations

None
Publications

                                  None

Additional Grants and Awards
                                  None

Project Status
                                2008-Extension approved.  Manuscript currently in preparation, not yet submitted.

 


 

Title of Grant

“Relative Effect of Cephalomedullary Nails Versus Sliding Hip Screw in the Treatment of Peri-trochanteric Hip Fractures on Mortality and Re-operation in a Community-Based Clinical Setting”

Grant Funded by

 OTA

Principal Investigator

 Saam Morshed, MD, MPH      

Co-Investigator

Theodore Miclau, MD

Amount and Date Funded:
                $10,000                                     June 1, 2007
Presentations

               Publications

                Additional Grants and Awards

Project Status

2008-Extension approved.  No update report received

 


 

Title of Grant
                “Time of Exposure to C-arm Drape Contamination”
Grant Funded by

 OTA
Principal Investigator

 Paul Peters, MD        

Co-Investigator

 Michael Prayson, MD

Amount and Date Funded:
                $10,000                                     June 1, 2007
Presentations

                                AmericanAcademy of Orthopaedic Surgeons (Poster), March 2008                            

Mid-America Orthopaedic Association (Podium), April 2008
OTA Annual Meeting Poster, October 2008
AAOS Podium Presentation, 2008/2009 because it was nominated for being one of the top resident papers at MAOA meeting in April, 2008

Publications
                                None     

Additional Grants and Awards

                                None

                Pending Publications

                Previously submited paper for publication in the JOT and the JBJS

                                Currently submitted to Journal of Orthopaedics

Project Status

Concluded

 


 

Grant Title
                “Operative vs. Non-operative Treatment of Ligamentous SER-4 Ankle Fractures: A

                Prospective, Randomized Study

Grant Funded by

 OTA

Principal Investigator

Nelson Saldua, MD  
Co-Investigator

Michael Mazurek, MD

Amount and Date Funded
                $10,000                                     June 1, 2007
Presentations
              None
Publications

                                None

Additional Grants and Awards

                                None

Project Status
                                2008 - Ongoing

 


Title of Grant
                                “Biomechanical Analysis of a New Locked Plating System for the Proximal Humerus”

Grant Funded by

OTA

Principal Investigator

Ross Schumer, MD     
Co-Investigator

Michael Prayson, MD

Amount and Date Funded
                $10,000                                     June 1, 2007
Presentations
                Military meeting, Las Vegas, December 2008
                AAOS Specialty Day, Las Vegas February 2009
                Mid America meeting, April 2009
                Ohio Orthopaedic Society May 2009
Publications
             Journal of Shoulder & Elbow Surgery; June 2010; 19 Issue 4

Additional Grants and Awards       

                None

New Product or Patent

                None

Project Status
                                2008 – Completed.
            


 

Title of Grant

“The Effect of Donor Age on the Healing Potential of (h)BMP-2-expressing, Adipose-Derived Multi-potential Progenitor Cells in the Young-Adult Rat Segmental Femur Defect Model”|

Grant Funded by

OTA
Principal Investigator

 Patrick Whitlock, MD, PhD      
Co-Investigator

 Lawrence X. Webb, MD

Amount and Date Funded:
                $10,000                                     June 1, 2007
Presentations

None

Publications

None
Abstract Submissions

1. Abstract OTA 2010 Annual Meeting, Baltimore
2. Abstract 2010 Challenges in Fracture Care Across Disciplines, Phoenix, AZ

Additional Grants and Awards

                                  None (Pending grants - AO North America)

Project Status
                                2008 – Project ongoing.  Grant extension approved.
                                2010 - Project ongoing.

 


 

Title of Grant

                 “The Effect of Sacral Fracture Malreduction on the Strength of Iliosacral Screw Fixation

 for Transforaminal Sacral Fractures

Grant Funded by

OTA

Principal Investigator

 Jason Young, MD     

Co-Investigator

                                Michael Stover, MD

Amount and Date Funded
                $10,000                                        January 2007
Presentations

None
Publications

None
Additional Grants and Awards       

None
Project Status
                2008- Research extended one year.

 

 

 

 

OTA 2007 RESIDENT $10,000 GRANT AWARDS

(Grant Cycle:  January 1, 2007 – December 31, 2007)

 

 

 

Title of Grant
                                  “Gait Analysis after Retrograde and Antegrade Intramedullary Nail Fixation of

   Femoral Shaft Fractures”

Grant Funded by

OTA/Foundation for Orthopaedic Trauma
Principal Investigator

 Sara Strebe, MD       

Co-Investigator

 Lisa Cannada, MD

Amount and Date Funded:
                $10,000                                    January 2007
Presentations

In progress

Publications

                                Expecting/pending publications

Additional Grants and Awards

                                None

Project Status

                2008 - Ongoing
                               2009 – Ongoing, still recruiting patients.

 

 


 

Title of Grant
                                “Utilizing Nanospheres to Transport Antibiotics Across the Cell Membrane to Kill

                Intracellular  Staphylococcus Aureus”

Grant Funded by

 OTA/ Foundation for Orthopaedic Trauma

Principal Investigator

 John Ellington, MD, MS

Amount Funded

 $10,000

Co-Investigator

 Michael Bosse, MD

Amount and Date Funded
                $10,000                                    January 2007
Presentations
                North Carolina Nano Biotechnology Research Award, July 2007          

Publications

                Res. Soc. Symp. Proc. Mater, Vol. 1019, 2007

Additional Grants and Awards
                Yes - 3 pending:  1. Aircast Foundation (98k), NCBC (258k),

Dept of Defense (2.5 million)

Project Status
                                  2008 – Project Concluded

 


 

Title of Grant
                                “Blinding of Outcome Assessors in Clinical Trials of Orthopaedic Trauma”

Grant Funded by

 OTA/ Foundation for Orthopaedic Trauma

Principal Investigator

 Paul Karanicolas, MD    

Amount Funded

 $10,000

Co-Investigator

 Mohit Bhandari, MD, MSc

Amount and Date Funded
             $10,000                                    January 2007
Presentations         

—     Inter-observer reliability of classification systems to rate the quality of femoral neck fracture reduction. Orthopaedic Trauma Association (OTA) Annual Meeting. Denver, USA. Oct. 15-18, 2008.

—     Creative Approach to Blinding of Outcomes: The Blinding Of Femoral Fixation (BOFF) Study. Orthopaedic Trauma Association (OTA) Annual Meeting. Denver, USA. Oct. 15-18, 2008.

—      Blinding of Outcomes in Trials of Orthopaedic Trauma: An Opportunity to Enhance the Validity of Clinical Trials. International Society for Fracture Repair. July 2008.

—      A Creative Approach to Blinding of Outcomes: The Blinding Of Femoral Fixation (BOFF) Study. International Society for Fracture Repair. July, 2008.

—      Inter-observer reliability of classification systems to rate the quality of femoral neck fracture reduction. European Federation of National Associations of Orthopaedics and Traumatology (EFORT) Congress. Nice, France. May 29-June 1, 2008.

—      Blinding of Outcomes in Trials of Orthopaedic Trauma: An Opportunity to Enhance the Validity of Clinical Trials. European Federation of National Associations of Orthopaedics and Traumatology (EFORT) Congress. Nice, France. May 29-June 1, 2008.

—     A Creative Approach to Blinding of Outcomes: The Blinding Of Femoral Fixation (BOFF) Study. European Federation of National Associations of Orthopaedics and Traumatology (EFORT) Congress. Nice, France. May 29-June 1, 2008 (Poster Award).

Publications

The Journal of Orthopaedic Trauma 23(6):408-12, July 2009
The Journal of Clinical Epidemiology 62(2):214-223, Feb 2009
The Journal of Bone and Joint Surgery - American volume. 90(5):1026-33, May 2008.

                Additional Grants and Awards

None

Project Status
                2008 – Financial Report Received
                2009 - Concluded

 


 

Title of Grant
“The Pathophysiology of Compartment Syndrome: Intracompartmental Pressure, Skeletal Muscle  Viability and Microcirculatory Changes”

Grant Funded by

OTA/ Foundation for Orthopaedic Trauma

Principal Investigator

 Abdel Rahman Lawendy, MD      

Amount Funded

 $10,000

Co-Investigator

 David Sanders, MD

Amount and Date Funded:
                                $10,000                                    January 2007
Presentations
Publications

Additional Grants and Awards

Project Status
                                2008 – No report received.

 


 

Title of Grant
                “The Effect of Obesity on Outcomes Among Trauma Patients with Lower Extremity

 Orthopaedic Injuries”

Grant Funded by

 OTA/ Foundation for Orthopaedic Trauma

Principal Investigator

 Rajshri Maheshwari, M.D.                          

                Amount Funded

 $10,000

Co-Investigator

Sean Nork, M.D.                                                           

Amount and Date Funded
                $10,000                                     January 1, 2007
Presentations

                                AAOS 75th Annual Meeting, San Francisco, CA, March 2008
                                Ruth Jackson Orthopaedic Society Biennial Meeting, October 2007
                                North Pacific Orthopaedic Society 82nd Annual Meeting, September 2007
                                University of Washington Resident Research Days, June 2007

Publications

                                Pending – Journal of Orthopaedic Trauma – Revisions submitted July 2008

Additional Grants and Awards

                                OREF/Depuy Orthopaedic Resident Research Grant                 $5,000 (1 year)
                                Frank B. Smith Memorial Award Paper                                           $1,000

 


 

Title of Grant
                “The Effect of Nitric Oxide on Intramedullary Vascularity and Fracture Healing”

Grant Funded by

 OTA

Principal Investigator

 James Meeker, M.D.                

 Amount Funded

 $10,000

Co-Investigator

 Laurence Dahners, M.D.

Amount and Date Funded
               $10,000                                    January 2007
Presentations

               Publications

               Additional Grants and Awards

Project Status
                                   2008 – No update received.

 


               

Title of Grant
                “The Influence of Racial and Economic Factors on the Treatment of Pediatric Fractures of

                                the Wrist and Forearm”

Grant Funded by

 OTA

Principal Investigator

 Matthew Oetgen, M.D.

Amount Funded

 $10,000

Co-Investigator

 Michael Baumgaertner, M.D.

Amount and Date Funded
                $10,000                                    January 2007
Presentations

                Publications

                Additional Grants and Awards

Project Status
                                2008 – Update not received.

 


  

Title of Grant
  “Use of Continuous Passive Motion in the Post-Operative Treatment of Intra-Articular Knee Fractures”

Grant Funded by

 OTA

Principal Investigator

 Jason Palmer, MD   

Amount Funded

 $10,000

Co-Investigator

 Kyle Jeray, MD

Amount and Date Funded
                $10,000                                    January 2007
Presentations

               Publications

               Additional Grants and Awards  

Project Status

2008 – Update not received.


 

Title of Grant
                                “The Role of Muscle Function In Fracture Healing”

Grant Funded by

 OTA

 

Principal Investigator

Scott Ruhlman, MD  

Amount Funded

$10,000

Co-Investigator

 Sean Nork, MD

Amount and Date Funded:
                $10,000                                    January 2007
Presentations
                March  2008 Poster Presentation - ORS

The work resulted in an abstract that was presented as a poster at the ORS in 2008.  The title was:  “Muscle Function is Critical for Successful Fracture Healing”.  His co-authors were Gross, Asuk, Becker, Nork, Bain.  This manuscript was also presented locally for Dr. Ruhlman’s resident research project.

Publications

This research has not resulted in publication directly as yet.  However, it is a critical component of the upcoming
manuscript(s) on muscle function and fracture healing.  The manuscript in preparation is “Transient muscle paralysis
impairs the osteogenic response to injury”. 

Additional Grants and Awards

This research has continued to be an important part of the research lab at the University of Washington.  The initial work by Dr. Ruhlman looking at transient muscle paralysis and fracture healing has resulted in ongoing studies funded by the Ted Hansen Chair, the Foundation for Orthopaedic Trauma, and Industry (Zimmer, Synthes).

Project Status

2008 – Grant extension approved to December 2008. 
2010 - Completed   


Title of Grant
                “The Effects of Mediators on Vascular Permeability in Ischemia-Reperfusion Injury”

Grant Funded by

 OTA

Principal Investigator

 Nicholas Souder, MD              

Amount Funded

 $10,000

Co-Investigator

 Robert Probe, MD

 Amount and Date Funded
              $10,000                                    January 2007
Presentations

                OTA Annual Meeting Poster Presentation, October 2007

Publications

                It has been submitted to JBJS and is currently under review.

Additional Grants and Awards

Project Status
                2008 – Project completed.


 

 

 

 

…………………………………………………………………………………………………………………………

 

2006

 

 

OTA 2006 GRANT AWARDS

 (Grant Cycle:  January 1, 2006 – December 31, 2006)

 

 

 

Title of Grant

“Fluid Irrigation Techniques in Patients with Open Fracture Wounds: A Multi-Center Blinded Randomized Controlled Trial  (F.L.O.W.) A Pilot Study”

Grant Funded by

 OTA/DePuy, a Johnson & Johnson Company

Principal Investigator

 Mohit Bhandari, MD  

Co-Investigator

 Emil H. Schemitsch, MD    

Amount and Date Funded
                $25,000/year for 2 years – January 2006 and January 2007
Presentations

Abstract submitted to AAOS  - pending
Plan to submit abstracts to COA and OTA - pending

Publications

1. Petrisor, B., Jeray, K., Schemitsch, E., Hanson, B., Sprague, S., Sanders, D. Bhandari, M.; FLOW Investigators. Fluid lavage in patients with open fracture wounds (FLOW): An international survey of 984 surgeons (BMC Musculoskeletal Disorders.
2008 Jan 23; 9:7.
2. Pending publications: The Journal of Bone and Joint Surgery, American Volume

Additional Grants and Awards

Yes.   The results of the pilot study demonstrated the feasibility and need for a definitive study. A multi-centre clinical trial is currently underway. The funding for the FLOW definitive study is:
U.S. Department of Defense    $950,000 USD     Sept. 2008 - June 2010
CIHR       $1.75 million CAD   Jan. 2009 - Jan. 2012

Project Status
                                2007 Update not received.
                                2008 Update not received.      
                                 2009 Update received. Project is concluded.


Title of Grant

“The Role of Parathyroid Hormone in the Mechanosensitivity of Fracture Healing”

Grant Funded by

OTA/Stryker

Principal Investigator

Michael J. Gardner, MD           

Co-Investigator

Joseph M. Lane, MD

Amount and Date Funded:
                $25,000                                     January 2006
Presentations
              Orthopaedic Trauma Association, October 2007
              Orthopaedic Research Society, February 2007

Publications
               Journal of Orthopaedic Research, November 2007 (in press)

Additional Grants and Awards
                                  None

Project Status
                                  Project Completed

 


 

Title of Grant

                “Investigation of Stem Cells in the Management of Atrophic Nonunions”

Grant Funded by

 OTA/Medtronic

Principal Investigator

 David J. Hak, MD      

Amount and Date Funded

$25,000                                                 January 2006

Presentations

None

Publications
               None

Additional Grants and Awards
                                AIOD - $50,000  2006

Project Status
                                Project Ongoing

                                2008- Project Complete 


Title of Grant

                                   “Effect Of IGF-1 and Range of Motion on Articular Cartilage After Fracture”

Grant Funded by

 OTA/EBI

Principal Investigator

 Thomas F. Higgins, MD          

Co-Investigator

 Brian D. Johnson, MD

Amount and Date Funded
                $25,000                                     January 2006
Presentations
               OTA Annual Meeting, October 2006

Publications
                                Manuscript submitted to OTA.  Further publications pending.
                                 Publications submitted to JOR -2008.

Additional Grants and Awards
                                1GF-1 Intra-articular FX  33,000 2006-2007

Project Status
                Ongoing – Excellent progress made on two fronts with research on effects of IGF-1 on

                cartilage repair after intra-articular fracture.  Proceeding in second phase.                           


            Title of Grant

                                “Anabolic Mechanisms of PTH During Fracture Repair”

Grant Funded by

 OTA

Principal Investigator

 Sanjeev Kakar           

Co-Investigator

 Paul Tornetta, III

Amount and Date Funded
                 $25,000                                       January 2006
Presentations

                                  None

Publications

                                  None

Additional Grants and Awards

                                Yes- Preliminary data being used as supportive data for a NIH grant

Project Status
                                2007 – Update not received

                                2008 – Project Ongoing 


Title of Grant

“A Prospective, Randomized, Double-Blind Placebo-Controlled Study of the Effects of
 Risedronate (Actonel®) on Fracture Healing in Elderly Patients with Intertrochanteric
Hip Fractures”

Grant Funded by

 OTA/Smith & Nephew

Principal Investigator

Melvin P. Rosenwasser, MD  
Co-Investigator

 Brian W. Su, MD   
Amount and Date Funded
                $25,000/year for 2 years – January 2006 and January 2007
Presentations
                None

Publications
                                None

Additional Grants and Awards
                                None

Project Status
                                Project Ongoing                                      


 

Title of Grant

                                “A Prospective Randomized Trial Investigating the Effect of a Novel Reamer-Irrigator-

                Aspirator on the Incidence of Fat Embolism and Respiratory Function During       Intramedullary Nailing of Femoral Shaft Fractures”

Grant Funded by

 AO North America

Principal Investigator

 Emil H. Schemitsch, MD         

Co-Investigator

 Michael D. McKee, MD        

Amount and Date Funded
                                $25,000 Jan. ’06 and $24,000 Jan. ’07

Presentations

None

Publications

None

Additional Grants and Awards

None

Project Status

2007 – Report not received as of October 2007.
2008 – Report not received as of October 2008.  
2009 - Report received.  The RIA study is a multi-centre trial with a principle site (St. Michael's Hospital) and an additional five participating co-invesitgative sites.
                             


 

Title of Grant

                                  “Radiation Prophylaxis for Post-Traumatic Heterotopic Ossification of the Elbow”

Grant Funded by

 Synthes

Principal Investigator

 Michael J. Bosse, MD (replacing Douglas Stull, MD)    

Amount and Date Funded

 $25,000 January 2006 and $24,218 January 2007

Presentations
                                None

Publications
                                   Publication pending completion of patient enrollment

Additional Grants and Awards
                                  Health Services Foundation - $32, 640.00

Project Status

                                   2008 Project Ongoing
                                   2009 Project Ongoing

 

 

 

OTA 2006 RESIDENT $10,000 GRANT AWARDS

(Grant Cycle:  June 1, 2006 – May 31, 2007)

 

 

 

 

Title of Grant
                “The Effects of Methylprednisolone on Neurotrophic Cytokines in an Acute Spinal Cord
                Injury Model”  

Grant Funded by

 OTA &  FOT

Principal Investigator

 Del Gaizo Daniel

Co-Principal Investigator

 Douglas Dirschl

Amount and Date Awarded
                                $10,000                                                      June 1, 2006      

Presentations
                                None

Publications
                                None

Additional Grants and Awards       

Project Status

                                In final stages of data collection.  Anticipated completion and manuscript submission is

 planned for September 30, 20007.

               


 

 

Title of Grant
                                “Immunosuppression in Traumatic Open Fracture”

Grant Funded by

 OTA & FOT

Principal Investigator

 Brock Lindsey

Co-Principal Investigator

 David Hubbard

Amount and Date Awarded
                $10,000                                                 June 1, 2006

Presentations

OTA Annual Meeting, October 2007 
American Academy of Orthopaedic Surgeons (poster) March 2008
Orthopaedic Research Society (podium) March 2008

Publications
                                 Journal of Orthopaedic Research (2 papers) accepted July 2009 - in press

Additional Grants and Awards 

A Pilot Study of Interleukin - 12 local Delivery for Infection Prevention After a Traumatic Open Fracture 

$100,151  Funding Cycle: 8/1/07 - 7/31/09

Project Status
                                Project Concluded                           


 

 

Title of Grant
                “Predictors of Outcome in Floating Elbow and Floating Elbow Variant Type Injuries”
Grant Funded by

OTA & FOT

Principal Investigator

Robert Golden          
Co-Principal Investigator

Jesse Jupiter

Amount and Date Awarded
                                $10,000                                                      June 1, 2006

Presentations
                New England Orthopaedic Society, November 2006
                New England Orthopaedic Society, 2007
Publications

                Pending
Additional Grants and Awards
                None
Project Status
                Project Ongoing.   The project will continue to acquire data and hopefully result in future

publications.  Unfortunately, patient recruitment for the study has been extremely difficult to this point.  This issue has attempted to be addressed by sending out multiple mailings to potential subjects, as well as following up on these mailings with phone calls.  The database from which potential subjects are drawn was also expanded by looking further back in hospital records using billing data to identify potential subjects who sustained their injuries prior to the implementation of the currently used prospective patient tracking database.  In addition, an addendum to the study protocol is in the process of being evaluated by our IRB to make participation in the study more convenient for patients in order to boost recruitment.  A collaboration has also been formed with a trauma center in Argentina to help increase available patient data.  It is hoped that with the addition of more data, significant conclusions will be reached resulting in future publications.     
July 2009 - Ongoing

 


 

 

Title of Grant
                “Loss of Wire Tension with Cyclical Loading in Ilizarov and Taylor Spatial Frame (TSF)

 Rings”
Grant Funded by

OTA & FOT
Principal Investigator

Elliott Vann
Co-Principal Investigator

Roman Hayda
Amount and Date Awarded
                $10,000                                                                 June 1, 2006
Presentations
                None yet.  Awaiting final data analysis – data collection is complete
Publications
                None
Additional Grants and Awards
                None
Project Status
               Project Ongoing                                                 


Title of Grant

 “A Cadaveric Injection Study of the Distal Femur Using a Soft-Tissue Sparing Lateral  Approach”

Grant Funded by

 OTA &  FOT
Principal Investigator

Corey Van Hoff
Co-Principal Investigator

 Laura Phieffer
Amount and Date Awarded
                $10,000                                                  June 1, 2006
Presentations
                None
Publications
                None
Additional Grants and Awards
                None
Project Status
                  Project Ongoing.       


Title of Grant
                “Comparative Performance of Locked and Conventional Plating Constructs in Composite                 Bone”
Grant Funded by

 OTA & FOT
Principal Investigator

 Benjamin Burkett
Co-Principal Investigator

David Seligson
Amount and Date Awarded
                 $10,000                                                June 1, 2006
Presentations
                AIOD-GKS Combined Meeting, Strasbourg, France, September 2007
Publications
                Journal of Orthopaedic Trauma, December 2006
Additional Grants and Awards
               None
Project Status
              Project Ongoing


Title of Grant
                “Ulnar Nerve Transposition During ORIF of Distal Humerus Fractures: Comparison of
                functional outcomes between patients who were treated with ulnar nerve transposition and
                those who were not”
Grant Funded by

 OTA &FOT
Principal Investigator

 Oscar Vazquez

Co-Principal Investigator

 Kenneth Egol
Amount and Date Awarded
                $10,000                            June 1, 2006
Presentations

Annual OTA meeting Boston - October 2007
Publications

Will be submitted to JBJS and other journals- April 2008               
Fate of Ulnar Nerve after ORIF of distal humerus fractures               
2008 Pending: Final paper to be submitted                                        
Second abstract submitted to AAOS for 2009

Additional Grants and Awards
                None
Project Status
              2007 – Update not received as of October 2007

2008 – Ongoing project                      


Title of Grant
“Osteoblast Responses to Fracture: A novel approach using gene expression microarray and proteomics”

Grant Funded by

 OTA & FOT

Principal Investigator

 Andrew Evans
Co-Principal Investigator

 Robert Simpson
Amount and Date Awarded
                $10,000                                                 June 1, 2006
Presentations

PublicationsAdditional Grants and Awards Project Status
2007 – Update not received as of October 2007.
2008 – Update not received as of October 2008.


Title of Grant
                “Accuracy of Radiographic Interpretation of Pelvic Ring Displacement”
Grant Funded by

OTA & FOT
Principal Investigator

Hobie Summers
Co-Principal Investigator

 Michael Stover
Amount and Date Awarded

 $10,000                              June 1, 2006
Presentations

None at this time.  Do anticipate some in the future
Publications
                None
Additional Grants and Awards
               Yes – Charlotte Mecklenburg Foundation for $10,000.
Project Status        

2007 – Ongoing project.
2008 – Project ongoing. The computer application portion has been completed and currently working
on the data collection process.  


Title of Grant
                “The Impact of Antegrade Intramedullary Reaming on Bacterial Persistence in Open

Femur Fractures”

Grant Funded by OTA & FOT

Principal Investigator James Romanowski

Co-Principal Investigator Michael Archdeacon
Amount and Date Awarded

$10,000                              June 1, 2006

Presentations
                University of Cincinnati Annual Research Day, 05/05/07
                Submitted to 2008 AAOS Academy Meeting, 03/2008
                2008 Mid-America Orthopaedic Annual Meeting Presentation 04/2008
                Will Submit to 2009 OTA Annual Meeting      

Publications
                Submission JOT Pending, Manuscript Completed

Additional Grants and Awards

Project Status
               Project Concluded

 


 …………………………………………………………………………………………………………………………

 

2005

 

 

OTA 2005 GRANT AWARDS

 (Grant Cycle:  January 1, 2005 – December 31, 2005)

 

 

 

 

Title of Grant       

                “Objective Assessment of Injury Severity in Complex Intra-Articular Fractures”

Grant Funded by

 OTA & Smith + Nephew

Principal Investigator

                Donald D. Andersen, PhD          Co-Investigator J. Lawrence Marsh, MD

Amount and Date funded

                $25,000                 January 2005

Presentations

                XXth Congress of the International Society of Biomechanics, August 2005
  52nd Annual Meeting of the Orthopedic Research Society, March 2006

                2006 Midwest Graduate Student Biomechanics Symposium, March 2006

                30th Annual Meeting of the American Society of Biomechanics, September 2006
  31st Annual Meeting of the American Society of Biomechanics, August 2007
  6th Combined Meeting of the Orthopaedic Research Societies, October 2007
  Basic Science Focus Forum, 23rd Annual OTA Meeting, October 2007
  23rd Annual Meeting of the OTA, October 2007
  54th Annual Meeting of the Orthopaedic Research Society, March 2–5, 2008,  
 San Francisco, California
 75th Annual Meeting of the American Academy of Orthopaedic Surgeons, 
 March 5–9, San Francisco, California
 24th Annual Meeting of the Orthopaedic Trauma Association, Denver, Colorado,      October 15-18, 2008

Publications

Journal of Orthopaedic Research, March 2005, vol. 23(3): 686-690
Journal of Orthopaedic Research, 26(8):1046-1052, 2008

Additional Grants and Awards

NIH and AO Research Fund
Continuing line of research with funding from the World Arthrosis Organization and the
NIH/NIAMS (an Anderson PI R21 and a Marsh PI project within a P50 CORT grant).

Project Status

Pending Grant: NIHR21 on Assessing Bone Fragment Displacement
Submitted 10/01/2006
Pending Grant: NIHR21, CORT Proposal, Project 4, Quantifying Injury Severity to
Assess Risk for Post-Traumatic OA
2006 – Project Ongoing
2007 – Project Ongoing.   Publication submitted to Journal of Orthopaedic Research July   of 2007.  Funding decision award due to high score is pending.
2008 – Concluded


 Title of Grant       

“A Prospective Randomized Multicentre Clinical Trial Comparing ORIF with Primary Subtalar Fusion in Patients with Severely Comminuted (Sanders IV), Displaced, Intra-articular Fractures of the Calcaneus”

Grant Funded by

 OTA & AO North America

Principal Investigator

               Kelly D. Johnston, MD       

Co-Investigator

                                Richard E. Buckley, MD  

Amount and Date funded

                                $25,000    January 2005

Presentations

                                Too early - RCT

Publications

                                Too early - RCT

Additional Grants and Awards

                                None

Project Status

2005 – Project Ongoing.                
2006 – Project Ongoing
2007 – Project Ongoing 
2008 – Project Ongoing  


Title of Grant       

                “A Multicenter, Prospective ,Randomized Trial of Non-Operative Versus Operative  

                Treatment For High- Energy Midshaft Clavicle Fractures”

Grant Funded by

OTA & Synthes

Principal Investigator

                Kyle J. Jeray, MD

Co-Investigator

                J. Scott Broderick, MD

 

                See Jeray 2004 for report. 


 

Title of Grant

                “The Effect of Ischemia on Murine Fracture Repair”

Grant Funded by

 OTA & Zimmer

Principal Investigator

                Ralph S. Marcucio, PhD

Co-Investigator

                                Theodore Miclau, III, MD

 Amount and Date funded

                $25,000                 January 2005

Presentations
                ORS Annual Meeting, March 2008
                ORS Annual Meeting, March 2007

                ORS Annual Meeting, March 2006

Publications

Journal of Orthopaedic Research 25(1):51-61, Ischemia Leads to Delayed Union during Fracture Healing:
A Mouse Model, June 2006
28 Iowa Journal, 2008, Tibial fracture decreases oxygen level a th the site of injury
Journal of Orthopaedic Research, 26(10): 1384-9, May 2008, Effect of age on vascularization during fracture repair

Additional Grants and Awards

2008 - None.  However, larger grant is still pending as of July 2007.
2009 - Yes, $25,000 award, 1/2007-12/2007 - Effects of rhBMP7 on fracture healing in an  ischemic environment

Project Status

2006 – Project Ongoing July 1, 2006: Mechanisms underlying ischemia – induced impairments in fracture healing.
2007 – Project Concluded.
2009 - Project Concluded.


Title of Grant       

                “Preoperative Hypertonic Saline Attenuates Postoperative Polymorphonuclear NeutrophilsPriming Following Reamed Intramedullary Rod Fixation of Femoral Fractures”

Grant Funded by: OTA & DePuy, a Johnson & Johnson Co.

Principal Investigator

                Wade R. Smith, MD

Co-Investigator

                Steven J. Morgan, MD   

Amount and Date funded

                $24,546                 January 2005

Presentations

               OTA Annual Meeting Denver, 2008

Publications

                                Submission for Journal of Orthopaedic Trauma for 2008 publication
                                Submission to OTA for 2008 Annual Meeting

Additional Grants and Awards

                                OREF Grant to study this data as pilot for large study

Project Status

                                2005 – Project Ongoing.

                2006 – Project delayed. Beginning June 2006.

                2007 – Anticipated Conclusion – December 2007

                2008 – Project Completed


Title of Grant

                “Effect of OP-1 on Gene Expression in Chronically Infected Femoral Segmental Defect

                in the Rat”

Grant Funded by

 OTA & Stryker Orthopaedics

Principal Investigator

                Andrew H. Schmidt, MD  
Co-Investigator: Xinqian Chen, MD 

Amount and Date funded

                $25,000                 January 2005

Presentations
                Orthopaedic Research Society 50th Annual Meeting

                ORS abstract to be submitted for the 2007 ORS meeting.

Publications

A paper is being written for submission to Journal of Orthopaedic Research or Journal of Orthopaedic Trauma.
Journal of Orthopaedic Trauma – Completed, review process, in press to appear in 2007
Clinical Orthop Rel Res - in press 2009. - Brick KE, Chen X, Lohr J, Schmidt AH, Kidder LS, Lew WD. rhBMP - 2 Modulation of Gene Expression in Infected Segmental Bone Defects.

Additional Grants and Awards

                Grant Award/Title: Midwest Orthopaedic Research Foundation

                Amount Awarded: $10,586.87         

Funding cycle: Jan. 1, 2006 – July 31, 2006.
New Bone Formation in Chronically, Infected Segmented Defect in the 1st Femur treated with BMP-2 and Local Antibiotic – Dept.of Defense $466,644 11/1/07-12/31/07
 Polymicrobial Chronic Infection – Dept. of Defense $418,647 1/1/07-12/31/07

Project Status

2006 – Project Completed, but data analysis is in progress.

2007 – Project Complete. 


 Title of Grant       

                “Effects of Bisphosphonates and Parathyroid Hormone (PTH) in an Osteoporotic Fracture Healing Rodent Model”

Grant Funded by

 OTA & EBI, a Biomet Company

Principal Investigator

                Jose B. Toro 
Co-Investigator: Joseph M. Lane, MD
Amount and Date funded

                $25,000                 January 2005

Presentations

Publications

Additional Grants and Awards Project Status
                                2007 - Update not received.
                                2008 - Update not received.

 

…………………………………………………………………………………………………………………………

 

2004

 

 

OTA 2004 GRANT AWARDS

 (Grant Cycle:  January 1, 2004 – December 31, 2004)

 

 

 

Title of Grant    

                “LMP Gene Transfer for Improvement of Bone Formation and Regeneration in an

                Animal Model”

Grant Funded by

OTA & Stryker Howmedica Osteonics

Principal Investigator

                Gary S. Gruen, MD

Project Status

                Research project cancelled.  Grant funding returned ($18,893.00)

 


 

Title of Grant       

                “The Effect of Cyclooxygenase-2 Inhibitors on Primary (Direct) Bone Healing”

Grant Funded by

OTA & Smith + Nephew Orthopaedics

Principal Investigator

                David J. Hak, MD 

Amount and Date funded 

                $25,687                 January 2004

Presentations

                ORS Annual Meeting, March 2006

Publications

In preparation, hopefully to be submitted to J. Orthopaedic Research in August 2006.

Additional Grants and Awards

None
Project Status

2005 – Project concluded. Manuscript is in preparation.
2007 – Manuscript completed; but not yet accepted.
2008 – Manuscript being revised for submission. 
2009 - Manuscript resubmitted to Journal of Orthopaedic Trauma in July 2009.

 


 

Title of Grant       

                “A Multicenter Prospective Randomized Trial of Non-Operative versus Operative

                Treatment for High Energy Mid-Shaft Clavicle Fractures”

Grant Funded by

 OTA & Synthes USA

Principal Investigator

                Kyle J. Jeray, MD 

Amount and Date funded 

                $20,000                 January 2004

                $25,000                 January 2005
Presentations

                None
Publications
                None
Additional Grants and Awards

                Grant/Award Title: OTA

                Amount Awarded: $25,000               

                Funding Cycle: 2005
Project Status

2005 – Ongoing. This study is still enrolling patients. Once the study has been completed we expect multiple publications. As enrollment continues, and once preliminary analysis has been done, we intend on submitting for additional research grants.

2006 – Ongoing.  This study is still open and actively enrolling patients.

2007 – This study is still ongoing and actively enrolling patients.

2008 – This study is still ongoing and actively enrolling patients.
2009 - 11 sites enrolling patients.  Once the study is concluded, it wil be submitted for publication. 


 Title of Grant       

                “Percutaneous Pinning vs. Open Reduction and Internal Fixation of Proximal

                Humeral Fractures: A Prospective and Randomized Comparison of Outcomes”

Grant Funded by

OTA & DePuy Ace, a Johnson & Johnson Co.

Principal Investigator

                Sean E. Nork, MD
Project Status

                 October 2005 – research project canceled. Money returned to the OTA Research Fund. 


Title of Grant       

                “Prospective Randomized Study of Internal Fixation vs. External Fixation of Distal Tibia

                Plafond Fractures”

Grant Funded by

OTA & AO North America

Principal Investigator

                William T. Obremskey, MD, MPH 

Amount and Date funded 

                $48,900                 January 2004

Presentations

                OTA Annual Meeting, Oct. 2006

Publications

Journal of Orthopaedic Trauma, Dec. 2007 (pending)

Additional Grants and Awards

                None

Project Status

2006 – Project Ongoing.

2008 – Project Concluded

 


…………………………………………………………………………………………………………………………

 

2003

 

 

OTA 2003 GRANT AWARDS

 (Grant Cycle:  January 1, 2003 – December 31, 2003)

 

 

 

Title of Grant       

                “The Role of Anabolic Supplementation to Enhance Soft Tissue Envelope in Fracture

                Healing”

Grant Funded by

 OTA & EBI/Biomet

Principal Investigator

                Jeffrey O. Anglen, MD 

Amount and Date funded 

                $19,536                 January 2003

Presentations

                OTA Annual Meeting, October 2004
                Comparative Orthopaedic Lab Day – University of Missouri, April 2004

                21st OTA Annual Meeting, October 2005

                OTA Specialty Day (AAOS Annual Meeting Chicago), March 2006

Publications
                JBJS-AM
Additional Grants and Awards

None
Project Status

2005 – Project ongoing. Publications pending.

2006 – Project concluded. 


Title of Grant       

                “Lower Extremity Driving Performance Following Complex Lower Extremity Trauma”

Grant Funded by

 OTA/Smith & Nephew Orthopaedics

Principal Investigator

                Kenneth A. Egol, MD 

Amount and Date funded 

                $19,428                                                 January 2003

Presentations

                Orthopaedic Trauma Association, October 2005
                AAOS, March 2006

Publications

Journal of Trauma, 2008, 65(6) 1435-38

Additional Grants and Awards

                None

Project Status

                2005 – Project concluded.  


 Title of Grant       

                “Biphasic Sustained Release of Antibiotics and OP-1 at the Site of Segmental Femoral

                Defects in Adult Male Rats”

Grant Funded by

 OTA/AO North America

Principal Investigator

                Ham A. Benghuzzi 

Amount and Date funded 

                $20,000                               January 2003

Presentations

                Rocky Mountain Bioengineering Symposium, April 2003

                Academy of Surgical Research, October 2003

                Academy of Surgical Research, October 2004

                Society for Biomaterials (Abstract), May 2004

Publications

                Journal of Investigative Surgery; Submitted November 2004 (Pending)

 Journal of Orthopaedic Trauma; Submitted November 2004 (Pending)
                Journal of Investigative Surgery. 2007 Jul-Aug;20(4):249-55. 

Journal of Investigative Surgery. 2007 May-Jun;20(3):149-55
  Biomed Scientific Instruments. 2007;43:194-199.

  Biomed Scientific Instruments 2007;43:188-93.

Additional Grants and Awards

                NIH Area Grant; Submitted January 2004 (Pending)

                Isotis; Submitted August 2004 (Pending)
                Isotis Received 2007
                NIH Proposal Submitted 2007
                NIH Proposal to be Submitted Feb. 2008

Project Status

Project Concluded


 

Title of Grant       

                “The Analysis of Distraction Osteogenesis Using the COX-1 and COX-2 Knockout

                Mouse Model”

Grant Funded by

 OTA/Zimmer

Principal Investigator

                John T. Gorczyca, MD 

Amount and Date funded 

                $13,309                 January 2003

Presentations

                OTA Basic Science Forum, October 2005.

Publications

 None

Additional Grants and Awards

None

Project Status

2006 – Project concluded.

 


Title of Grant       

                “Linking Scores of the Sickness Impact Profile and Short Musculoskeletal Function

                Assessment Scales: A Prospective Study”

Grant Funded by

 OTA/Synthes, USA

Principal Investigator
                        Ricardo Pietrobon, MD

Amount and Date funded 

                $19,890                 January 2003

Presentations

                Not yet

Publications

                JBJS  (accepted for 2004)

                                Journal of Physical Activity and Health, April 2004 v. 1(2)

Additional Grants and Awards

                                Pending Grant: NIH                             June 2004

                Pending Grant: OREF                         October 2004

Project Status

2006 – Report not received
2007 – Report not received
2008 – Report nor received 


Title of Grant       

                “Orthopaedic Trauma Assessment Instrument Generated Using Item Response Theory”

Grant Funded by

 OTA/Stryker Howmedica Osteonics

Principal Investigator

                Mark S. Vrahas, MD 

Amount and Date funded 

                $16,239                 January 2003

Presentations

                AAOS Annual Meeting, March 2004

                OTA Annual Meeting, October 2004

Publications

ABJS, Sept. 2006; 88: 1927-1933

Additional Grants and Awards

                                Applied for OREF Grant in October 2004.                      

Pending: Computed adapted testing for Trauma Outcomes, tentatively funded by AO Foundation, currently working out IP issues.

Project Status

2003 - Ongoing       
2004 – Project concluded.


Title of Grant       

                “Intracellular Staphylococcus Aureus: A Proposed Mechanism for the Indolence of

                Osteomyelitis”

Grant Funded by

 OTA/DePuy Ace, a Johnson & Johnson Co.

Principal Investigator

                Lawrence X. Webb, MD 

Amount and Date funded 

                $19,910                 January 2003

Presentations

AAOS, February 2003; OTA Annual Meeting, October 2003; Nanotechnology Conference, December 2004; NCOA, June 2006; OTA Annual Meeting, October 2006, Orthopaedic Research Society (podium) Feb. 2009; FASEB (poster) - April 2009

Publications
Osteomyelitis and intraosteopblastic Staphylococcus Aureus, 2007 16:73-78
Encapsulated Staphylococcus aureus Strains vary in adhesiveness assessed by atomic force microscopy,
May 2009, 89:402-410
Journal of Bone & Joint Surgeons, vol. 85, August 2003
Journal of Orthopaedic Research, January 2006

Additional Grants and Awards

                Grant/Award Title: OREF "Targeting the glycocalyx to reduce bone/implant related

                infections"                                   

                Amount Awarded: $98,202   Funding Cycle: July 1, 2006 - June 30, 2009
 Grant/Award Title: Translational Science Institute Wake Forest University School of   Medicine, "The use of nanoparticles to target osteomyelitis", $50,000,

Funding Cycle

January 2008 - December 2009

Project Status

 2006 – Project concluded.
 2009 - Intracellular bacteria in osteoblasts cultured from patients with osteomyelitis in preparation for submission in September of 2009.

 

 

 

 

 

 

…………………………………………………………………………………………………………………………

 

2002

 

 

OTA 2002 GRANT AWARDS

 (Grant Cycle:  January 1, 2002 – December 31, 2002)

 

 

 

Title of Grant       

                “The Role of Anabolic Supplementation to Enhance Soft Tissue and Fracture Healing”

Grant Funded by

 OTA/EBI

Principal Investigator

                Timothy A. Burd, MD

 

Amount and Date funded 

                $19,971                 January 2002

Presentations

                ISFR, October 2002

Publications

                                Journal of Bone and Joint Surgery American, November 2006

Additional Grants and Awards

                Submitted

Project Status

                Project Concluded


 

Title of Grant       

                “The Effect of Low Molecular Weight Heparin on Fracture Healing in a Standardized Rat

                Femur Fracture Model”

Grant Funded by

 OTA/AO North America

Principal Investigator

                David J. Hak, MD 

Amount and Date funded 

                $14,651                 January 2002

Presentations

International Society for Fracture Repair, October 2002; Orthopaedic Research Society, February 2003; AAOS Annual Meeting, February 2003

Publications

Journal of Orthopaedic Research, 2006; 24(4):645-652

Additional Grants and Awards

                No

Project Status

                Project Concluded 

Title of Grant       

                “Do Variations in Pulsatile Lavage Pressure Affect Cancellous Bone Structure and

                Fracture Healing”

Grant Funded by: OTA/Stryker Howmedica Osteonics

Principal Investigator

                Douglas R. Dirschl, MD 

Amount and Date funded 

                $19,872                 January 2002

Presentations

                None

Publications

Journal of Orthopaedic Trauma, 2006, 20:261-266

Additional Grants and Awards

                None

Project Status

                Animal surgery finished 5/02. Data analysis ongoing.

                2003 – Project concluded.


 Title of Grant       

                “Use of Direct BMP-2 Gene Delivery to Enhance the Healing of Segmental Bone

                Defects: Evaluation in a Rat Model”

Grant Funded by

 OTA/Synthes

Principal Investigator

                Christopher H. Evans, MD 

Amount and Date funded 

                $20,000                 January 2002

Presentations

                Orthopaedic Research Society, 2003 (New Orleans)

Publications

                Journal of Bone & Joint Surgeons, vol. 88-A #2, Feb. 2006       

Additional Grants and Awards

               Based upon the preliminary data obtained with our OTA grant, we have secured a 5-year   RO1 grant from NIAMS (AR 050243)

Project Status

                2002 - Work has been in progress for 7 months, and great data is being received.

                However, it is too soon to publish or present, or secure further funding.

                Project Concluded. 


Title of Grant       

                “Comparison of IMN vs. Cast in Stable Tibia Fractures”

Grant Funded by

 OTA/DePuy Ace

Principal Investigator

                William T. Obremskey, MD 

Amount and Date funded 

                $48,377                 January 2002

Presentations

                OTA Annual Meeting, Oct. 2006

Publications

                Journal of Orthopaedic Trauma, Dec. 2007 (pending)

Additional Grants and Awards

                None

Project Status

                Animal surgery finished 5/02. Data analysis ongoing.

                2005 – Project ongoing.

                2006 – Project ongoing.

                2008 – Project complete.


 Title of Grant       

                “Study to Prospectively Evaluate Reamed Intramedullary Nailing in Tibial Fractures: A

                Multi-Center Randomized Trial”

Grant Funded by

 OTA/AO North America

Principal Investigator

                Gordon  Guyatt, MD 

Amount and Date funded 

                $50,000                 January 2002

Presentations

                AAOS Annual Meeting, San Francisco, California, March 2004

Publications

Controlled Clinical Trials, 2003
Sprint Manuscripts Accepted for Publication

—      S.P.R.I.N.T. Investigators. Randomized Trial of Reamed versus Non-Reamed Intramedullary Nailing of Tibial Shaft Fractures. J Bone Joint Surg Am. In Press, December 2008.  

—      S.P.R.I.N.T. Investigators. Study to Prospectively Evaluate Reamed Intramedullary Nails in Patients with Tibial Fractures (S.P.R.I.N.T.): Study Rationale and Design. BMC Musculoskelet Disord.  2008, 9:91 (23 Jun 2008).  *Recipient of the International Society for Fracture Repair (ISFR) 2008 Best Paper Award.

Presented SPRINT Abstracts

                —      S.P.R.I.N.T. Investigators. (Bhandari, M). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Rates of Re-operation in Patients with Fractures of the Tibia. Orthopaedic Trauma Association (OTA) 23rd Annual Meeting, Boston, MA, October 2007.

 

                —      S.P.R.I.N.T. Investigators. (Tornetta, P). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Functional Outcome in Patients with Fractures of the Tibia. Orthopaedic Trauma Association (OTA) 23rd Annual Meeting, Boston, MA, October 2007.

 

                —       S.P.R.I.N.T. Investigators. (Bhandari, M). Reamed versus Non-Reamed Tibial Intramedullary Nail Insertion on Re-operation Rates. AmericanAcademy of Orthopaedic Surgeons (AAOS) 75th Annual Meeting, San Francisco, CA, March 2008.

 

                —       S.P.R.I.N.T. Investigators. (Sanders, D). Functional, General, and Disability Outcomes after Tibial Nailing: A Randomized Trial. AmericanAcademy of Orthopaedic Surgeons (AAOS) 75th Annual Meeting, San Francisco, CA, March 2008.

 

                —      S.P.R.I.N.T. Investigators. (Swiontkowski, MF). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Rates of Re-operation in Patients with Fractures of the Tibia. Mid-American Orthopaedic Association 26th Annual Meeting, Champions Gate, FL, April 2008.

 

                —       S.P.R.I.N.T. Investigators. (Goslings, JC). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Functional Outcome in Patients with Fractures of the Tibia. Dutch Association for Trauma Surgery Annual Meeting, Netherlands, November 2007.

 

                —        S.P.R.I.N.T. Investigators. (Bhandari, M). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Rates of Re-operation in Patients with Fractures of the Tibia. Canadian Orthopaedic Association (COA) 63rd Annual Meeting, Quebec City, QC, June 2008.

 

                —       S.P.R.I.N.T. Investigators. (Schemitsch, E). Functional, General, and Disability Outcomes after Tibial Nailing: A Randomized Trial. Canadian Orthopaedic Association (COA) 63rd Annual Meeting, Quebec City, QC, June 2008.

 

                —        S.P.R.I.N.T. Investigators. (Bhandari, M). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Rates of Re-operation in Patients with Fractures of the Tibia. 81st Annual Congress of the Japanese Orthopaedic Association, Sapporo, Japan, May 2008.

 

                —       S.P.R.I.N.T. Investigators. (Bhandari, M). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Rates of Re-operation in Patients with Fractures of the Tibia. European Federation of National Associations of Orthopaedics and Traumatology (EFORT) 9th Annual Congress, Nice, France, May/June 2008.

 

                —       S.P.R.I.N.T. Investigators. (Bhandari, M). Functional, General, and Disability Outcomes after Tibial Nailing: A Randomized Trial. European Federation of National Associations of Orthopaedics and Traumatology (EFORT) 9th Annual Congress 2008, Nice, France, May/June 2008.

 

                —      S.P.R.I.N.T. Investigators. (Bhandari, M). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Rates of Re-operation in Patients with Fractures of the Tibia. International Society for Fracture Repair (ISFR) Biennial Meeting 2008, Lake Tahoe, CA, July 2008.

 

                —       S.P.R.I.N.T. Investigators. (Bhandari, M). Functional, General, and Disability Outcomes after Tibial Nailing: A Randomized Trial. International Society for Fracture Repair (ISFR) Biennial Meeting 2008, Lake Tahoe, CA, July 2008.

 

                Accepted SPRINT Abstracts

                —      S.P.R.I.N.T. Investigators. (Busse, J). A Comparison of the Discriminative Ability and Responsiveness of the Short Musculoskeletal Function Assessment Questionnaire Function Index and the Short Form-36 Physical Summary Score among Tibial Fracture Patients. Orthopaedic Trauma Association (OTA) Annual Meeting 2008, Denver, CO, October 2008.

 

Additional Grants and Awards

                Grant/Award Title: OREF – for Sprint Economic Analysis

                Amount Awarded: $100,000                             

                Funding Cycle: July 2005 – June 30, 2007
                Grant/Award Title: Canadian Institute of Health Research

                Amount Awarded: $499,952 ($CAN)              

                Funding Cycle: April 2004 – March 2007

                Grant/Award Title: National Institute of Health

                Amount Awarded: $980,940                             

                Funding Cycle: May 2002 –2005

                Grant/Award Title: Canadian Institute of Health Research

                Amount Awarded: $701,533 ($CAN)              

                Funding Cycle: April 2001 – March 2004

                Grant/Award Title: Orthopaedic Research & Education Foundation

                Amount Awarded: $100,000                             

                Funding Cycle: July 2002 –2004

                Grant/Award Title: Zimmer Orthopaedics

                Amount Awarded: $34,125 ($CAN) 

                Funding Cycle: December 2000 – 2001

                Grant/Award Title: Hamilton Health Sciences Corporation

                Amount Awarded: $25,000 ($CAN) 

                Funding Cycle: October 2000 – 2001

                Grant/Award Title: Medical Research Council

                Amount Awarded: $90,988 ($CAN) 

                Funding Cycle: April 2000 – March 2001

Project Status

               Project is still recruiting patients, and will not be completed until 2005.

               2003 – Requested additional funding from CIHR for Canadian centers.

               2004 – Project On-going. Several publications expected.
               2005 – Recruitment has stopped, currently following patients.

2006 – Pending publications to be determined 2007 – Completed patient follow-up in 2006 - Primary paper draft completed with intent to submit it to journals in September
2008 – Update of the numerous publications and presentations resulting from this study record above.  Continuing to conduct secondary analyses and expect additional publications and presentations over the next year. 


 Title of Grant       

                “Enhancement of Fracture Healing and BMP Induced Bone Formation by Traumatic

                Brain Injury”

Grant Funded by

 OTA/Synthes

Principal Investigator

                Uwe Scherbel, MD  

Amount and Date funded 

                $20,000                 January 2002

Presentations

AAOS, February 2001; IBMS and ECTS, June 2001; OTA, October 2001 (poster);
OTA, October 2002 (poster)

Publications

                Pending

Additional Grants and Awards

                None

Project Status

                2003 – Project ongoing
                2008 – No additional updates received 


Title of Grant       

                “Traumatic Brain Injury and Enhanced Osteogenic Potential in a Rat Model”

Grant Funded by

 OTA/Zimmer

Principal Investigator

                Paul Tornetta, III, MD 

Amount and Date funded 

                $19,607                 January 2002

Presentations

Orthopaedic Trauma Association, October 2004
AAOS Poster Presentation, February 2005

Publications

                JBJS, 2007

Additional Grants and Awards

                None

Project Status

                2003 – ORS abstract submitted July 2003, manuscripts to be submitted to JOR or JBJS

                upon completion (October).

                2005 – Project Completed.

…………………………………………………………………………………………………………………………

 

2001

 

 

OTA 2001 GRANT AWARDS

 (Grant Cycle:  January 1, 2001 – December 31, 2001)

 

 

 

Title of Grant       

“A Multicenter, Prospective Randomized Trial of Non-operative and Operative 
Treatment of Displaced Clavicular Shaft Fractures”

Grant Funded by

 OTA/DePuy Ace, a Johnson & Johnson Company

Principal Investigator

                Michael D. McKee, MD  

Amount and Date funded 

                $20,000                 January 2001

Presentations

                Orthopaedic Trauma Association, October 2005

Publications

                                JBJS (A), January 2007

Additional Grants and Awards

                                  Grant/Award Title: Zimmer Research Grant  

                Amount Awarded: $10,000                               

                Funding Cycle: 2001 – 2003
                2006 Specialty Day Edwin G. Bovill, Jr., MD Award

Project Status

2004 – 130 patients enrolled to date.  Project concluded.


Title of Grant       

                “A Multicenter Prospective Randomized Trial of Open Reduction and Internal Fixation

                vs. Total Elbow Arthroplasty for Severe Fractures of the Distal Humerus in Elderly

                Patients”

Grant Funded by

 OTA/Aventis Pharmaceuticals

Principal Investigator

                Michael McKee, MD  

Amount and Date funded 

                $20,000                 January 2001

Presentations

                OTA Annual Meeting, October 2006

Publications
                                JSES, 2007 (accepted for publication)

Additional Grants and Awards

                                Grant/Award Title: Zimmer Research Grant  

                                Amount Awarded: $10,000                Funding Cycle: 2001 – 2003

                                 OTA Edwin Bovill Award, 2007
                ASES Neer Award, 2007

Project Status

Concluded

 


Title of Grant       

                “Treatment of Displaced Femoral Neck Fractures in the Elderly: An Outcome Study of

                Patient Prospectively Randomized to Internal Fixation, Hemiarthroplasty or Total Hip

                Replacement.”

Grant Funded by

 OTA/Zimmer

Principal Investigator

                Kenneth Egol, MD 

Amount and Date funded 

                $25,000                 January 2001

Presentations

                None

Publications

                                None

Additional Grants and Awards

                None

Project Status

2002 - Project Not Concluded. Although funded in 2001, we didn’t get full IRB approval until 2002. Data collection began the end of Jan. 2002. In 5 months we have entered 15 patients so far.

2003 – Study has been discontinued and remaining funds returned because of the “STARS” trial.

…………………………………………………………………………………………………………………………

 

2000

 

 

OTA 2000 GRANT AWARDS

 (Grant Cycle:  January 1, 2000 – December 31, 2000)

 

 

 

Title of Grant       

                “Biodegradable Antibiotic Impregnated Rods for the Treatment of Osteomyelitis”

Grant Funded by

 OTA/AONA

Principal Investigator

                Jeffrey Anglen, MD  

Amount and Date funded 

                $19,552                 January 2000

Presentations

                AOA Resident’s Conference, February 2000

Publications

Journal of Orthopaedic Trauma, vol. 15, Aug. 2001;
Clinical Orthopaedics and Related Research, vol. 441 (280-287), 2003

Additional Grants and Awards

None

Project Status

                                2001 – Project concluded 


Title of Grant       

                “Apoptosis in Articular Cartilage Injury”

Grant Funded by

OTA/Ace DePuy

Principal Investigator

                Joseph Borrelli, MD 

Amount and Date funded 

                $19,581                 January 2000

Presentations

                Orthopaedic Trauma Association, October 2001
                American Fracture Association, November 2001

Publications

Submitted to Journal of Orthopaedic Trauma, May 2002         

Additional Grants and Awards

Plans are currently underway to develop a RO3 grant through the NIH. The specific aims of this grant will include determining mechanism of apoptosis and possible means of preventing apoptosis. The information gained from this investigation will provide pilot data for a larger investigation. Submitted 6/21/02                    

Project Status

Expected Publications – “Chondrocyte Apoptosis Following Impact Loading in an in-vivo Rabbit Model.”

“Mechanism of Chondrocyte Apoptosis Following Articular Injury.”

Pending Grants – This data will be included in an RO3 grant currently being developed.
2002 – Project Concluded. 


Title of Grant       

                “The Effect of Tourniquet Control on Intramedullary Reaming”

Grant Funded by

 OTA/Smith & Nephew Richards

Principal Investigator

                Madhav A. Karunakar, MD  

Amount and Date funded 

                $19,984                 January 2000

Presentations

                Orthopaedic Trauma Association, October 2002

                American Association of Orthopaedic Surgeons, February 2003

Publications

Journal of Orthopaedic Trauma (provisionally accepted)

Additional Grants and Awards

Grant/Award Title: Best Poster, OTA Annual Meeting, October 2002                     

Project Status

2003 – Project concluded 


Title of Grant       

                “Sprint – A Prospective MultiCenter Study of Reamed vs.Unreamed Tibial Nails”

Grant Funded by

OTA/AONA

Principal Investigator

                Gordon H. Guyatt, MD  

Amount and Date funded 

                $20,000                 January 2000

Presentations

American Academy of Orthopaedic Surgeons Annual Meeting, San Francisco, California, March 2004 Publications Controlled Clinical Trials, 2003

Additional Grants and Awards               

Grant/Award Title: OREF – Sprint Economic Analysis

                                Amount Awarded: $100,000                                             

Funding Cycle: July 2005 – June 2007

                Grant/Award Title: Canadian Institute of Health Research

                Amount Awarded: $499,952 ($CAN)                              

Funding Cycle: April 2004 – March 2007

                                Grant/Award Title: National Institute of Health

                Amount Awarded: $980,940                                             

Funding Cycle: May 2002 –2005
                Grant/Award Title: Canadian Institute of Health Research

                                Amount Awarded: $701,533 ($CAN)                              

Funding Cycle: April 2001 – March 2004

                                Grant/Award Title: Orthopaedic Research & Education Foundation

                Amount Awarded: $100,000                                             

Funding Cycle: July 2002 –2004

                                Grant/Award Title: Zimmer Orthopaedics

                                Amount Awarded: $34,125 ($CAN)                 

Funding Cycle: December 2000 – 2001

                                Grant/Award Title: Hamilton Health Sciences Corporation

                                Amount Awarded: $25,000 ($CAN)                 

Funding Cycle: October 2000 – 2001

                                Grant/Award Title: Medical Research Council

                                Amount Awarded: $90,988 ($CAN)                 

Funding Cycle: April 2000 – March 2001

                Project Status

2001 – Project ongoing.

Pending grants: NIH – submitted June 2001; OREF * – submitted August 2001; OTA * – submitted August 2001; AO International * – submitted August 2001

* Submitted in case NIH funding is not granted.

2005 – Project ongoing. Multiple publications pending.


Title of Grant       

                “Characterization of Callous Mineralization and Collagen Using FT-IRI in the             

                Rabbit Ulna Model: The Effects of Rigid Fixation”

Grant Funded by

 OTA

Principal Investigator

                Joseph M. Lane, MD 

Amount and Date funded 

                $14,825 January 2000

Presentations

                Not yet

Publications

Not yet

Additional Grants and Awards

Grant/Award Title: NIH – Osteoporosis Collegen Cross-link and Biomechanics

Amount Awarded: $1,174,464         

Funding Cycle: 9/28/01 – 7/31/04                     

Project Status

2000 - Pending Publication – When completed will be submitted to JOR and OTA

Pending Grants – NIH – Grant FTIR on FX Healing, Date submitted: 6/00

2001 – Project ongoing. Publications and related grants expected once completed.
2002 – Project ongoing. Awaiting Histology. Pending Publications: JOR, OTA

2003 – Due to construction in research facilities, FTIR was delayed. Anticipating concluding the study within the next 6 months.

2004 – New instrument will arrive on 9/1/04 to complete study. 


Title of Grant       

                “Percutaneous Treatment of an Experimental Tibial Atrophic Non-Union: A Gene

                Therapy Approach in a Rabbit Model”

Grant Funded by

 OTA/AONA

Principal Investigator

                Christian Lattermann, MD  

Amount and Date funded 

                $19,984                 January 2000

Presentations

 None

Publications

None

Additional Grants and Awards

None                      

Project Status

Pending Publication

Effect of BMP-2 & VEGF alone and in combination on the healing of an experimental non-union using a gene therapy approach.

Last update received in 2001. 


Title of Grant       

                OTA/AONA Grant Expression of Indian Hedgehog and Bone Morphogenetic

                Proteins in Rats at 6 and 32 Weeks of Age

Grant Funded by

OTA/AONA

Principal Investigator

                Ralph A. Meyer, PhD  

Amount and Date funded 

                $19,233                 January 2000

Presentations

                Orthopaedic Research Society, February 2001; International Bone and Mineral Society,

                June 2001; Orthopaedic Trauma Association, October 2001; International Society for

                Fracture Repair, October 2002; American Society for Bone and Mineral Research,

                September 2002

Publications

Pending

Additional Grants and Awards

                Grant/Award Title: DNA Microarray Facility/The Charlotte Genomics Consortium

                Funding Cycle: July 2001 – June 2002
                Amount Awarded: $223,000             

Project Status

The experimental phase is completed. The data analysis continues and additional

manuscripts are expected.

Pending Publications: Bridging callus formation in adult rats with femoral fractures:

Expression of VEGF and FGF – 1and 2 but not Ihh and the BMPs. B.J. Desai, M.H.

Meyer, S. Porter, J.F. Kellam and R .A. Meyer, Jr. Submitted to JOT, July 2002.

Microarray analysis of femoral fracture in rats. The effect of age. R.A. Meyer, Jr., B.J.

Desai and M.H. Meyer. Data now being analyzed.


 

Title of Grant       

                “BMP Function in the Presence of Local Antibiotics”

Grant Funded by

 OTA/Smith + Nephew

Principal Investigator

                Steven Olson, MD  

Amount and Date funded 

                $6,000   January 2000

Presentations

                International BMP Symposium, June 2000

Publications

None

Additional Grants and Awards

None              

Project Status

2001 – Project concluded


 

Title of Grant       

                “Can Topical Antiseptics or Antibiotics Normalize the Bacterial Count of

                Superficial Dermal Abrasions, Effectively Extending the Safe Surgical Window

                for Closed Fractures?”

Grant Funded by

 OTA/Zimmer

Principal Investigator

                Laura Senunas Phieffer, MD  

Amount and Date funded 

                $26,774                 January 2000

Presentations

                Orthopaedic Trauma Association, October 2000; AAOS, March 2001

Publications

Publication in Journal of Orthopaedic Trauma.  Date submitted: 8/01
Additional Grants and Awards

None

Project Status

2001 – Project Concluded. 


Title of Grant       

                “Bone Morphogenetic Protein Treatment of the Infected Bone Defect”

Grant Funded by

OTA/Synthes USA

Principal Investigator

                Andrew H. Schmidt, MD  

Amount and Date funded 

                $18,263                 January 2000

Presentations

24th Annual Meeting, American Society for Bone and Mineral Research, September 2002;
5th European Trauma Congress, Vienna, May 2002; 17th Annual Orthopaedic Trauma Association, October 2001 (poster); Orthopaedic Research Society 2003

Othopaedic Trauma Association, October 2001

Publications

                                Journal of Orthopaedic Trauma, vol. 18(7), page 436, 2004

               Journal of Orthopaedic Research, vol. 23, p. 816, 2005
Additional Grants and Awards

                NIH grant submitted 2003               
                                Grant/Award Title: OTA/Effect of OP-1 on Gene Expression in Chronically
                                Infected Fractures              
                                Funding Cycle: 2005 Amount Awarded: $25,000

Project Status

2005 – Project ongoing.
Pending Publication: JBJS Fall 2005.
Pending Grant: Medtronic, Fall 2005. 


Title of Grant       

                “High Pressure Parallel Lavage for Wound Debridement: A Comparison of
              Traditional Methods”

Grant Funded by

 OTA

Principal Investigator

                Lawrence X. Webb, MD  

Amount and Date funded 

                $20,000                 January 2000

Presentations

                Poster, Orthopaedic Trauma Association, October 2000

Publications

Manuscript in preparation

Additional Grants and Awards
 Pending Grants - no cost extension of unexpended funds to be requested from OTA to complete clinical study


…………………………………………………………………………………………………………………………

 

1999

 

 

OTA 1999 GRANT AWARDS

 (Grant Cycle:  January 1, 1999 – December 31, 1999)

 

 

 

Title of Grant       

                “Enhancement of Fracture Healing by a Marrow Osteogenic Cell Transfected with IGF-1”

Principal Investigator

                David Diduch, MD  

Amount and Date funded 

                $30,772                 January 1999

Presentations

                UVA Orthopaedic Alumni Meeting, November 1999; Virginia Orthopaedic Society, May

                2000; Orthopaedic Trauma Association, October 2000

Publications

                                Pending: Journal of Orthopaedic Trauma

Additional Grants and Awards

                Grant/Award Title: OREF: Articular Cartilage Repair Using Cells

                Transfected with IFG – 1

                Amount Awarded: 225,000

                Funding Cycle: 3 Years

Project Status

Manuscripts and grant applications will be submitted when this research is completed.

2000 – Update not received.

2001 – Project Concluded

Pending Grants – NIH – This project plus larger projects. Plan to submit 10/01


Title of Grant       

                “Cost and Cost Effectiveness of Reconstruction vs. Amputation”

Principal Investigator

                Ellen MacKenzie, PhD  

Amount and Date funded 

                $27,263                 January 1999

Presentations

None       

Publications

 Pending publications:
                1) Long-term Costs of Amputation vs. Reconstruction

                                2) Indirect Costs of Major Lower Limb Trauma

Additional Grants and Awards

                                Grant/Award Title: Six-year Follow-up of LEAP Study Patients

                                Amount Awarded: $1,507,623

                                 Funding Cycle: NIAMS/1999 - 2002

Project Status

2001 - Data collection and analysis completed; publications planned, manuscripts are drafted.       


 Title of Grant       

                “The Role of Angiogenesis in Bone Development and Repair”

Principal Investigator

                Theodore Miclau, MD  

Amount and Date funded 

                $20,000                 January 1999

Presentations

                Orthopaedic Research Society, 2000 & 2001; Orthopaedic Trauma Association,

                2000 & 2001

Publications

               Current Opinions in Orthopaedics, 2001

              Journal of Orthopaedic Research, 2003

               Development, 2003           

Additional Grants and Awards

Grant Award/Title: Musculoskeletal Transplant Foundation 

Amount Awarded: $225,000

Funding Cycle: January 2000 – January 2003

Grant Award/Title: National Institute of Health 

Amount Awarded: $500,000

Funding Cycle: April 2000 – April 2006

Project Status

                Completed 


Title of Grant       

                “Pathogenesis and Prevention of Ankle Osteoarthritis after Tibial Plafond

                Fractures”

Principal Investigator

                J. Lawrence Marsh, MD  

Amount and Date funded 

                $15,000                 January 1999

Presentations

               Orthopaedic Trauma Association Annual Mtg., October 2003;

               27th Annual Meeting of the American Society of Biomechanics, September 2003;

Orthopaedic Research Society Annual Mtg., March 2004; Mid-America Orthopaedic Association Annual Mtg., April 2004; VA Medical Center Research Week (Iowa City), March 2004; American Academy of Orthopaedic Surgeons Annual Mtg., March 2004;
Orthopaedic Trauma Association Annual Mtg., October 2004; 4th Annual Meeting of the International Society for Computer Assisted Orthopaedic Surgery, June 2004; American Academy of Orthopaedic Surgeons Annual Mtg., February 2005

Publications

                Journal of Bone & Joint Surgeons, 2003 Feb.; 85-A(2): 287-95

                Clinical Orthopaedic and Related Research, June 2004

                Journal of AmericanAcademy of Orthopaedic Surgeons, May 2003

Additional Grants and Awards

                Grant/Award Title: NIH/SCOR Grant

                                Amount Awarded: $750,000

                                 Funding Cycle: Sept. 2002 – Sept. 2007               
                                 Grant/Award Title: Arthritis Foundation

                                 Amount Awarded: $8,789

                                 Funding Cycle: July 2003 

Project Status

                2003 - This project is not concluded, and work continues in the following areas:

Full development of website database.

Four sites continue to enroll study patients, submit data to central database and follow outcomes.

An additional study site has been added to the Plafond group.

Continue to review preliminary data and currently have 20 patients enrolled.

The laboratory continues to gather data…measurement of injury severity and quality of fracture reduction.

2005 – Expected publication submission after final data collection of 2-year data

                                (Dec. 2004 – Jan. 2005) 


Title of Grant       

                “The Effect of Sacral Fracture Malreduction on the Safe Placement of Iliosacral

                Screws: An Intraosseous Anatomic Study”

Principal Investigator

                Mark Reilly, MD 

Amount and Date funded 

                $12,000                 January 1999

Presentations

                Orthopaedic Trauma Association, October 1999; AAOS - OTA Specialty Day, 2000;

                Orthopaedic Trauma Association, October 2000, AmericanAcademy of Orthopaedic

                Surgeons, 2000

Publications

                Journal of Orthopaedic Trauma, June 2001 (pending)

Additional Grants and Awards

Grant/Award Title: AONA    

Amount Awarded: $10,000               

Funding Cycle: 2001 - 2002

Project Status

                                2001 – Project concluded

Title of Grant       

                “An Investigation of Influence of Fat Embolism and Hypotension on Pulmonary

                Pathophysiology”

Principal Investigator

                Emil Schemitsch, MD  

Amount and Date funded 

                $59,848                 January 1999

Presentations

                Orthopaedic Research Society, February 2002

                International Society for Fracture Repair, September 2002
                Canadian Orthopaedic Association, June 2002
                3 abstracts submitted to ORS for 2003

Publications

                Manuscript submission pending to Journal of Orthopaedic Trauma
                3 Papers for JOR in preparation.

Additional Grants and Awards

                                  Submission to Canadian Institutes of Health Research pending.

Project Status

                2001 – This grant was funded for a 2-year period. Part 1 is complete (2 abstracts and 1

                                  journal submission). Part 2 will be complete in 6 months, leading to more presentations

                and publications.

                                 Pending grants: Submission to Canadian Institutes of Health Research planned for March

                2002 – Project Complete

 


Title of Grant       

                “Kinematic and Kinetic Behavior of the Ankle Following Supination-External

                Rotation”

Principal Investigator

                Neil Sharkey, PhD  

Amount and Date funded 

                $19,995                 January 1999

Presentations

                6th Annual Meeting of Gait and Clinical Movement Analysis Society, Sacramento,

                California, 2001

                International Meeting of the Biomechanics Society, July 2001

Publications

                Journal of Bone and Joint Surgeons, January 2002 (accepted in press)

                Gait to Posture, March 2002 (accepted, minor revisions)

Additional Grants and Awards

The PI has been awarded funding (as Co-Principal Investigator) for research projects that will employ methods developed or perfected over the course of our OTA funded work, although they have a different research focus. We are also exploring the possibility of submitting an NIH grant aimed at total ankle arthroplasty, which is more closely related to our trauma research.

Bone Strain During OG Exercise (NASA), $718,639, 6/1/00-5/31/03

Therapeutic Footwear in Diabetes (NIH), $998,308, 7/1/00-6/30/03

2002 – New grant applications related to this research will be submitted this year.

Project Status

1999 – Project is ongoing. All experiments have been completed and data analysis in underway. Anticipate at least 2 presentations (ORS, OTA and/or ASB), and publication in JOT, FGA.

2000 – We are currently preparing two manuscripts that correlate with the two     aforementioned abstracts, but contain a large amount of additional material. We anticipate these to complete by January 2001. The first will submitted to the Journal of Bone and Joint Surgery and the second to the Journal of Biomechanics.

2001 – Project will not be considered complete until at least two manuscripts have been accepted for publication.
2002 – Project Complete (Pending Grant: Biomechanical Factors Affecting Stress Reactions to Fractures; to be submitted in 2002 – 2003). 


 Title of Grant       

                “Effect of Articular Step-Off and Presence or Absence of the Meniscus on

                Contact Pressures of Fractures of the Lateral Tibial Plateau”

Principal Investigator

                Philip Wolinsky, MD

Amount and Date funded 

                $9,000                   January 1999

Presentations

                Poster – Orthopaedic Trauma Association, 1999

Publications

                Journal of Orthopaedic Trauma, vol. 15(2):101-106, 2001

Additional Grants and Awards

                                  Grant/Award Title: Zimmer

                                  Amount Awarded: To be determined

                                  Funding Cycle: 2001

Project Status

                                   2000 - Ongoing

                                  2001 – Project Complete

 

…………………………………………………………………………………………………………………………

 

1998

 

 

OTA 1998 GRANT AWARDS

 (Grant Cycle:  January 1, 1998 – December 31, 1998)

 

 

 

Title of Grant       

                “The Effect of Ultrasound on Distraction Osteogenesis”

Principal Investigator

                Fred Behrens, MD  

Amount and Date funded 

                $19,982                 January 1998
Presentations

                Orthopaedic Research Society, March 2000; ASAMI, March 2000

Publications

                Manuscript in preparation

Additional Grants and Awards

Grant/Award Title: NSF/Effect of Mechanical Loading History on Distraction Osteogenesis             Amount Awarded: $195,000         Funding Cycle: May 2000 – May 2004

Project Status

Project Concluded 


Title of Grant       

                “Surfactants for the Disinfection of Complex Wounds”

Principal Investigator

                Jeffrey Anglen, MD  

Amount and Date funded 

                $20,000                 January 1998

Presentations

OTA, 1998; Missouri State Orthopaedic Association, 1998; Musculoskeletal Infection Society 8th Annual Meeting, 1998; American Bone and Joint Surgeons;  Association of Bone and Joint Surgeons, May 1999 and May 2000; Mid-America Orthopaedic Association, April 2000; Musculoskeletal Infection Society, August 2000; European Bone and Joint Infection Society, May 2000; Mid Central States Orthopaedic Society, June 2000

Publications

                Journal of Orthopaedic Trauma, vol. 13 (5), 1999; American Journal of

                Orthopaedics, vol. 28 (3), 1999; Southern Medical Journal, In press

Additional Grants and Awards

                Grant/Award Title: VA Merit Award (same title)            

                Amount Awarded: $250,000

                Funding Cycle: 3 years

Project Status

                1999 - The project continues with additional funding as noted above, and more

                publications are expected.

                2000 – Project Concluded 


Title of Grant       

                “Biomechanical Consequences of Femoral Head Impaction”

Principal Investigator

                William Holmes, MD  

Amount and Date funded 

                $10,000                 January 1998

Presentations

None

Publications

None

Additional Grants and Awards

                None

Project Status

                Project concluded.


Title of Grant       

                “An Economic Evaluation of Internal Fixation as Compared with Bipolar

                Hemiarthroplasty for Displaced Femoral Neck Fractures”

Principal Investigator

                Susan Jaglal, PhD  

Amount and Date funded 

                $12,000                 January 1998

Presentations

                Hip Fracture Interest Group Symposium, University of WesternOntario, Keynote

                Address, October 1998     

Publications

                Journal of Orthopaedic Trauma, vol. 12 (230-234), 1998

                Journal of Bone and Joint Surgery, vol. 82-A (955-962), 2000

Additional Grants and Awards

                                None

Project Status

                                2002 – Completing data collection this year.

                                2003 – Project concluded. Manuscript in preparation


Title of Grant       

                “The Role of Apoptosis in Fracture Healing”

Principal Investigator

Kalia Sadasivan 

Amount and Date funded 

$29,800                 January 1998

Presentations

None

Publications

Journal of Orthopaedic Trauma, vol. 13, 1999

Mol. Biol., vol. 46, 2000      

J. Trauma, vol. 48, 2000 
Additional Grants and Awards

The grant led to additional awards, but not to a larger grant. An orthopaedic

resident (MLO) received awards from the Orthopaedic Research and Education

Foundation and the Mid-America Orthopaedic Association. On the basis of that

work, she earned a fellowship in orthopaedic research at the Karolinska Institute.
Project Status

Project Concluded 


Title of Grant       

                “The Effects of Locally Applied Antibiotics on Human Fibroblasts and T-

                Lymphocytes in Vitro”

Principal Investigator

                Theodore Miclau, MD 

Amount and Date funded 

                $9,465                   January 1998

Presentations

                “Orthopaedic Trauma Association Annual Meeting, October 1999; Orthopaedic    Research Society”, March 2000

Publications

                Submitted to: Journal of Orthopaedic Research

Additional Grants and Awards

                None

Project Status

                                2000 - The project is not yet fully concluded.

                                2001 – No changes.

                                2002 – No changes.

                                2003 – Project concluded


 

Title of Grant       

                “A Molecular Approach to Accelerate Fracture Repair”

Principal Investigator

                Theodore Miclau, MD  

Amount and Date funded 

                $20,000                 January 1998
Presentations

Orthopaedic Trauma Association, Annual Meeting, October 1998; American Academy of Orthopaedic Surgeons, 66th Annual Meeting, February 1998; Orthopaedic Research Society, 45th Annual Meeting, February 1999; Orthopaedic Research Society, 1999; Orthopaedic Trauma Association, 1999; American Academy of Orthopaedic Surgeons, 1999; Orthopaedic Research Society, 2000

Publications

                                Annals of the New YorkAcademy of Sciences, vol. 857, 1998

                                Does adult fracture repair recapitulate embryonic skeletal formation? Mechanisms

                                of Development, 1999

                Journal of Orthopaedic Research, 2001
Additional Grants and Awards

                                Grant/Award Title: OREF - Howmedica Grant

                                Amount Awarded: $150,000
Grant/Award Title Musculoskeletal Transplant Foundation 

                Amount Awarded: $225,000
                  Funding Cycle: January 2000 – January 2003
Grant/Award Title National Institute of Health 

                Amount Awarded: $500,000

                Funding Cycle: April 2000 – April 2005
Project Status

                2000 – Manuscript in preparation

                2002 – Project concluded.

 

…………………………………………………………………………………………………………………………

 

1997

 

 

OTA 1997 GRANT AWARDS

 (Grant Cycle:  January 1, 1997 – December 31, 1997)

 

 

 

Title of Grant       

                “Similarities in the Molecular Cues Mediating Bone Formation and Repair”

Principal Investigator

                Anh Le, MD 

Amount and Date funded

                $11,500                 January 1997

Presentations

                Orthopaedic Research Society, 1997; Inman and Abbot Society Meeting, 1997;

                Orthopaedic Trauma Association, 1997

Publications

                Skeletal Growth and Morphogegesis; another work is in preparation.

Additional Grants and Awards

                Grant/Award Title: Orthopaedic Research Educational Funds

               Amount Awarded $15,000

Project Status

                                  Project concluded. 

Title of Grant       

                                “A Prospective Field Trial to Assess the Reliability, Validity, and Responsiveness              

                                  of the Short Form Musculoskeletal Function Assessment Instrument (SMFA)”

Principal Investigator

                Marc Swiontkowski, MD 

Amount and Date funded 

                $43,682                 January 1997

Presentations

                AmericanAcademy of Orthopaedic Surgeons, 1997; Visiting Professorships; Maine

                Medical Assessment Foundation, 1997; AAOS Symposium, 1998; Canadian Orthopedic

                Association Annual Mtg, 1998; OTA, 1999; AAOS (x2), 2000

Publications

                JBJS, September 1997, vol. 79A, pgs. 1323-1335

JBJS, September 1999, vol. 81A, pgs. 1245-1260
 Pending Publications for Orthopaedics and Journal of Medical Outcomes
 Pending Publications: “Use of Interactive Voice Response as a mode of Admission” SMFA - Date submitted: February 2000

“Feasibility of using SMFA in Office Practice” JBJS, Date Submitted: August 1999

Additional Grants and Awards

None

Project Status

                                1999 - Project in data analysis phase. Anticipate publication in approx. 1 year.

2000 – Project Concluded.

 


 

Title of Grant       

                “Therapeutic Role of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in

                Infected Fractures of Rabbit”

Principal Investigator

                Andrew Schmidt, MD 

Amount and Date funded 

                $19,892                 January, 1997

Presentations

                None

Publications

                None

Additional Grants and Awards

                Grant/Award Title: OTA Grant, “BME Treatment of the Infected Bone Defect”

                Amount Awarded: $18,263                               

Funding Cycle

 2000-2001

Project Status

                1999 – Possible publications and related grants expected.

                2000 – Project Concluded (Pending Grant from NIH)

                                2001 – Project Concluded 


Title of Grant       

                “Mechanical Strength of Fracture Callus in Osteopenic Bone at Different Phases of

                Healing”

Principal Investigator

                Donna Wheeler, PhD 

Amount and Date funded 

                $24,914                 January 1997

Presentations

                Orthopaedic Trauma Association, October 1998

Publications

                Journal of Orthopaedic Trauma, vol. 14(2):86-92, 2000

Additional Grants and Awards

                None

Project Status

                Additional publications and related grants expected.

                2000 – Update not received.

                2001 – Project Concluded 


Title of Grant       

                “Mechanical Influences on Fracture Repair Process”

Principal Investigator

                James Goulet, MD 

Amount and Date funded 

                $21,500                 January 1997

Presentations

                Orthopaedic Research Society, 1997 and 1998

                American Society of Mechanical Engineers, 1997

Publications                        

                Journal of Bone and Mineral Research, November 1997; Journal of Clinical I

                Investigation, October 1997; Journal of Bone Mineral Research, vol. 14(11), November

                1999; Journal of Bone Mineral Research, vol. 15(5), May 2000

Additional Grants and Awards

                Grant/Award Title: NIH

                Musculoskeletal CoreCenter: Mechanical and Biological Influences on Bone Response

                Amount Awarded: $3,006,395

                Funding Cycle: 4/1/01 – 3/30/06

Project Status

                Project status unknown. Update not received in 1999.

                2000 – Update not received.

                2001 – Project concluded. 


Title of Grant       

               “Development of an In-Vivo Model of Long-Term Consequences of Acetabular   Fractures”

Principal Investigator

                Steven Olson, MD 

Amount and Date funded 

                $19,717                 January 1997

Presentations

                Orthopaedic Trauma Association, October 1998

                Orthopaedic Research Society – pending 2002

Publications

                Pending Publications: Development of an in-vivo model of Intra-articular fx.

Additional Grants and Awards

                                Pending

Project Status

                2001 – Project Concluded

                Pending Grants: ORS Career Development Award – Submitted 8/2001

                                NIH RO3 – Submitted 2/2001

                                Genetics Institute – Submitted 6/2001

 


 

Title of Grant       

                “Role of Endogenous Hormones in the Control of Bone Blood Flow”

Principal Investigator

                John Fleming, PhD 

Amount and Date funded 

                $15,000                 January 1997

Presentations

Gill Heart Institute Research Forum, October 1998; Orthopaedic Research Society Annual Meeting, 1999; Seminar Presentation, Rudd Heart & Lung Institute, August 1999; Seminar Presentation, Indiana State University, October 1999; Thesis defense, University of Louisville, July 1999; Accepted for Presentation at the AAOS 67th Annual Meeting, 2000; Submitted to Orthopaedic Research Society Annual Meeting, 2000;

Publications                        

                Submitted to Microcirculation, October 1999

                Journal of Orthopaedic Research 20:391-396, 2002

Additional Grants and Awards

                Grant/Award Title: National Institutes of Health, Aging Institute

                “Estrogen: Bone blood flow and Bone Biomechanical Properties”

                Amount Awarded: $50,000                               

   Funding Cycle: 6/1/99 – 5/30/01               
Grant/Award Title: Fischer-Owen Orthopaedic Research Fund

                “Effect of Low Level Ultrasound Stimulation on Bone Blood Flow”

                Amount Awarded: $14,924                               

   Funding Cycle: 1/1/99 – 12/31/99               
Grant/Award Title: University of Louisville, School of Medicine

                “Cortical Bone Vascular Reactivity Following Bone Injury”

                Amount Awarded: $15,000                               

                Funding Cycle: 1/1/99 – 12/31/99
Project Status    

1999 – Jeremy Feitelson, a graduate student in my lab, conducted his Master’s thesis research in one area of this grant. He has now enrolled in the doctoral program and plans to conduct his dissertation research in a bone blood flow area. He has not decided if his PhD research will continue in the same area or a new area of bone blood flow regulation. Additional papers and presentations related to the topic of the grant will be forth coming if he decides to continue in the thesis research area for his dissertation research. However, since the OTA funding expired some time ago, funding for this future research must come from other sources.

               2002 – Project concluded.

 


Title of Grant       

                                “Periarticular Bone Strain Changes Resulting from Pilon Fractures:  The Effect of       

                                Cartilage and Subchondral Bone Loss”

Principal Investigator

                Todd McKinley, MD 

Amount and Date funded 

                $15,000                 January 1997

Presentations

                Biomed Engineering Society, October 1998; AOA Resident’s Conference,

                March 1999; Orthopaedic Trauma Association, October 1999; Orthopaedic Research

                Society (multiple), February 1999

Publications

Journal of Orthopaedic Research, September 2001, 19(5): 906-13
Journal of Orthopaedic Trauma, 2001; CORR, 2001; Journal of Biomechanical Engineering, 2001; Journal of Orthopaedic Trauma, 2002 October, 16(9): 638-43;
Journal of Orthopaedic Trauma, 2002 November – December, 16(10): 709-16;
Journal of Biomechanical Engineering, 2003 February, 36(2): 155-63;
Clin Orthop., 2003 February, (407): 259-67  

                2 articles accepted for: Journal of Orthopaedic Trauma Accepted 2002

Additional Grants and Awards

                Grant/Award Title: Bank of America Gianinni Foundation Medical Research 

                Amount Awarded: $25,000

 Funding Cycle: Over           
Grant/Award Title: OREF/Zimmer Career Development

                Amount Awarded: $50,000

 Funding Cycle: 2001 – 2002            
Grant/Award Title: National Institute of Health/Pathomechanical Etiology of Post-

                Traumatic Arthritis

                Amount Awarded: $320,000

 Funding Cycle:  2003
Grant/Award Title: “Centers for Disease Control: Traumatic Injury Biomechanics Research/

  Unstable Joints: Cartilage Stress Anomaly and Osteoarthritis”

                Amount Awarded: $890,000

                Funding Cycle: 2003

Project Status

                2000 – Pending Publications: Journal of Orthopaedic Research, Date Submitted:

                August 2000; CORR, Date Submitted: August 2000

                Pending Grants: OREF/Zimmer, Date Submitted: October 2000

                2001 – Project not concluded, finishing manuscripts

                Pending Grants: SCOR Grant, Univ. of  Iowa – submitted 9/01

                2002 – Pending Grant: Centers for Disease Control, Biomechanics of Injury Grant

                2003 – Project Concluded

 

…………………………………………………………………………………………………………………………

 

1996

 

 

OTA 1996 GRANT AWARDS

 (Grant Cycle:  January 1, 1996 – December 31, 1996)

 

 

 

Title of Grant       

                “Development of an In Vivo Die-punch Intra-articular Fracture Model”

Principal Investigator

                Joseph Borrelli, MD 

Amount and Date funded 

                $12,000                 January 1996

Presentations

                Orthopaedic Trauma Association, 1995; Local research meeting at the Hospital

                for Special Surgery, New York; (Note: Dr. Borelli believes this work was

                presented at a national biomechanical meeting by Dr. P. Torzilli (co-investigator).

                He will contact Dr. Torzilli at Hospital for Special Surgery to confirm.)

Publications        

Journal of Orthopaedic Trauma, 1997; Journal of Biomechanical Engineering, Vol. 121(5); Pgs 433-441, 1999

Additional Grants and Awards

                Grant/Award Title: OREF (foundation grant #98-009)

                Amount Awarded: $50,000/year 

Funding Cycle  2 years

Grant/Award Title: “OREF, Articular Cartilage Damage Following Impact Load: An in-vivo Rabbit Model”

Amount Awarded  $100,000

Funding Cycle: July 1998 – June 2000

Project Status

1999 – The apparatus constructed from these funds will continue to be utilized to assess the effects of the rate of load application on articular cartilage. It is anticipated that the results of these experiments will be published in the future.

2000 – Project Concluded

 


 

Title of Grant       

                “In Vitro Stability and Contact Stresses of the Hip Following Simulated                 Acetabular Fractures”

Principal Investigator

                Kevin Thomas, PhD 

Amount and Date funded 

                $16,500                 January 1996

Presentations

American Society of Biomechanics, September 1997; Poster Exhibit, Southern Biomedical Engineering Conference, April 1997; Orthopaedic Trauma Association, October 1997; American Academy of Orthopaedic Surgeons, March 1998; Orthopaedic Research Society, March 1998

Publications

Proceedings of the 16th Annual Southern Biomedical Conference, 1997; Journal of Rehabilitation Research and Development, vol. 34, 1997; Conference Proceedings of the 21st Annual Meeting of the American Society of       Biomechanics, 1997; Journal of Rehabilitation Research and Development, vol. 35, 1998; Orthopaedic Transactions, vol. 21(4), 1997 – 1998; Transactions of the Orthopaedic Research Society, vol. 22, 1998; Orthopaedic Transactions, vol. 22(1) 1998 – 1999; Journal of Bone and Joint Surgery, vol. 81A, 1999

Additional Grants and Awards

                Grant applications submitted to AO ASIF Research Commission, Louisiana Board

                of Regents Support Fund, and Orthopaedic Research and Education Foundation.

                None received funding.

Project Status

                2001 – Project concluded.


 

Title of Grant       

                “Assessment of Reamer System Mechanical Loads and Resultant Histopathology as

                Factors Affecting Intramedullary Pressurization”

Principal Investigator

                Richard Peindl, PhD 

Amount and Date funded 

                $14,595                 January 1996

Presentations

43rd Meeting of the Orthopaedic Research Society, February 1997; ASME/AIChE/ASCE Bioengineering Conference, June 1997; American Orthopaedic Association Residents' Conference, March 1997

Publications

                Journal of Orthopaedic Trauma, vol. 12, 1998

                Proceedings of the 1997 Bioengineering Conference, ASME, June 1997

                Proceedings of Orthopaedic Transactions, vol. 21, 1997- 1998

Additional Grants and Awards

                Grant/Award Title: "The Development of a Biological Safe Intramedullary Reamer

                System"

                Genetics Institute

                Amount Awarded: $5,000

Project Status

                1999 – Project led to development of an alternative reamer head design; currently

                investigating commercialization with orthopaedic companies.

                2000 – Project concluded.

 


 

Title of Grant       

                “The Effects of Applied Intermittent Vibration On Fracture Healing in the Rabbit   Tibial

                Osteotomy Model”

Principal Investigator

                James Nepola, MD 

Amount and Date funded 

                $18,628                 January 1996

Presentations

                Orthopaedic Trauma Association, 1996

Publications        

                None

Additional Grants and Awards

                Grant Submitted to EBI

Project Status

                Project concluded. 

 


 

Title of Grant       

                “The Effectiveness of Unipolar Versus Bipolar Prostheses in the Clinical             Management of the Elderly with Displaced Fracture of the Femoral Neck: A Pilot Study”

Principal Investigator

                Harry Rubash, MD 

Amount and Date funded 

                $16,000                 January 1996

Presentations

                MGH Service Line Development Committee

Publications

                None

Additional Grants and Awards

                None

Project Status

                1999 – Dr. Rubash moved to MGH from UPMC in 1998. The OREF grant was

                transferred, and we are in the process of getting the study approved at MGH.

                2000 – The pilot is concluded. We are considering a multi-center trial.

                Pending Grant: Re-submit NIH Grant as multi-center study based in Boston hospitals.

                2001 – Project concluded. Considering re-submitting to NIH as multi-center study at

                PartnersHospital.

 


Title of Grant       

                “The Effect of Nicotine on Tibial Shaft Fracture Healing in the Rabbit Model”

Principal Investigator

                Maureen Finnegan, MD 

Amount and Date funded 

                $20,000                 January 1996

Presentations

Orthopaedic Trauma Association Annual Meeting, 1997; AAOS Specialty Day, 1998;   Canadian Orthopedic Association, 1999; Association of Bone and Joint Surgeons, 1999

Publications - None

Additional Grants and Awards

                None

Project Status

                1999 – Presently working on publication

                2000 – Project Concluded


 

Title of Grant       

                “Does Bone Morphogenetic Protein Accelerate Fracture Healing in a Rabbit Limb             Lengthening Model?”

Principal Investigator

                Fred Behrens, MD 

Amount and Date funded 

                $17,740                 January 1996

Presentations

                Research Round, UMDNJ; Orthopaedic Trauma Association, 1998

                Society for Biomaterials, April 1999

                New JerseyBiomaterialsCenter Symposium, June 2000        

Publications

                Trans. Soc. Biomater, vol. 21, 1998;                Trans. Soc. Biomater, vol. 22, 1999;

                Transactions Orthopaedic Trauma Association, 1998; Soc. Biomater, 1998

Additional Grants and Awards

                Grant/Award Title: Student Fellowship for the Whitaker Special Opportunity Award for

                Statewide Program in Biomaterials Science

                Amount Awarded: $23,010

 Grant/Award Title: Materials donated by Intermedics Orthopaedic

                Amount Awarded: $5,400

                Grant/Award Title: Materials donated by Sulzer Orthopedics Biologics, Inc.

                Amount Awarded: $10,320

Project Status

                Pending Publication: PhD Dissertation (Lisa Holt)   Date Submitted: January 2001

                Pending Publication: Journal Article (2) to be submitted, January 2001

                2001 – Publications undergoing revisions.

                2002 – Project Concluded


 

Title of Grant       

                “Acute Lung Injury Associated with Femoral Shaft Fractures”

Principal Investigator

                Andrew Pollak, MD 

Amount and Date funded 

                $18,900                 January 1996

Presentations

                Orthopaedic Trauma Association Meeting, 1998

Publications

JOT, November 2000 (pending publication)

Additional Grants and Awards - None

Project Status

                1999 – More publications expected

 


Title of Grant       

                “The In-Vivo Effect of Locally Applied Aminoglycosides on Bone Healing”

Principal Investigator

                Theodore Miclau, MD 

Amount and Date funded 

                $14,700                 January 1996

Presentations

                None

Publications

                None

Additional Grants and Awards

                None

Project Status

                2002 – Project concluded.

…………………………………………………………………………………………………………………………

 

1995

 

 

OTA 1995 GRANT AWARDS

 (Grant Cycle:  January 1, 1995 – December 31, 1995)

 

 

 

Title of Grant       

                “The Efficacy of Gentamicin Impregnated Resorbable Calcium Phosphate

                Cement in Treating Experimental Osteomyelitis in a Rat Model”

Principal Investigator

                Michael Baumgaertner, MD 

Amount and Date funded 

                $12,000                 January 1995

Presentations

                Orthopaedic Trauma Association, 1997

Publications

                Journal of Orthopaedic Trauma, Vol. 13, No. 2, 1999 

Additional Grants and Awards

                No

Project Status

                2001 – Project Concluded


Title of Grant       

                “Percutaneous Screw Insertion to Sacroliac Complex: Bony Anatomy”

Principal Investigator

                Fred Behrens, MD 

Amount and Date funded 

                $10,000                 January 1995

Presentations

                Poster Presentations at Orthopaedic Research Society and AOA Meetings;         SICOT, 1999; OTA, 1996 and 1997

Publications

                Manuscript is undergoing further revisions and to be resubmitted by 7/1/03.

Additional Grants and Awards

                Grant/Award Title: Related OTA grant to Dr. Mark Reilly 

                Amount Awarded: $17,000

                Funding Cycle: 1998/1999

Project Status

                2000 - Project Complete (Publication to be submitted November 2000)

                2001 – Publication undergoing revisions 11/00

                2002 – Manuscript to be re-submitted
                2003 – Project Concluded 

 


 

Title of Grant
           “Reamed Intramedullary Nailing in the Face of Pulmonary Injury in Sheep”

Principal Investigator

                Kenneth Johnson, MD 

Amount and Date funded 

                $12,000                 January 1995

Presentations

                Canadian Orthopaedic Association Annual Meeting, 1997; AAOS

Publications

                Journal of Orthopaedic Trauma, vol. 12(3), 1998

Additional Grants and Awards

                None

Project Status

                Project concluded.


Title of Grant       

                “Randomized Multicenter Clinical Trial of Distal Radius Fracture Treatment”

Principal Investigator

                Hans Kreder, MD 

Amount and Date funded 

                $10,000                 January 1995

Presentations

                AmericanAcademy of Orthopaedic Surgeons, 1995; Manus, 1995; Canadian   Orthopaedic Association, 1995; SICOT, 1999; Orthopaedic Trauma Association, 1999;

                COA, 1999 and 2000

Publications

                Journal of Hand Surgery, vol. 21A(1), 1996

                Journal of Bone and Joint Surgery, vol. 78-B, 1996

Additional Grants and Awards

                Grant/Award Title: OREF

                Amount Awarded: $144,760

                Grant/Award Title: University of Toronto

                Amount Awarded: $44,915

Project Status

                1999 - Enrollment into one study arm is completed. The other  study arm is ongoing.

 Three additional publications are expected, one of which will be

  submitted within the next few months.

                2001 – Last patient enrolled in arm 2 in 1999, follow-up ended in April 2001.

                Last patient enrolled in arm 1 in 2000, follow-up will end in October 2001

                Interim data not submitted as planned. Plan is to submit two final papers only.
                2003 – Publications pending.


 

Title of Grant       

                “Displaced Acetabular Fractures: Influence of Surface Displacement on Articular                 Cartilage and Subchondral Bone Stress Distribution”

Principal Investigator

                Michael Voor, MD 

Amount and Date funded 

                $10,000                 January 1995

Presentations

               AmericanAcademy of Orthopaedic Surgeons; Mid-America Orthopaedic Association;  Orthopaedic Trauma Association, 1997

Publications

                Not Yet

Additional Grants and Awards

                None

Project Status

                1999 - Project concluded, but a manuscript is under internal review for

                submission to the Journal of Orthopaedic Trauma.

                2000 - A manuscript remains in preparation. OTA will be informed when it goes

                out for review.

                2001 – No changes to report.

                2002 – No changes to report.
                2003 – No changes to report.

 

…………………………………………………………………………………………………………………………

 

1994

 

 

OTA 1994 GRANT AWARDS

 (Grant Cycle:  January 1, 1994 – December 31, 1994)

 

 

 

Title of Grant       

                “Notch Sensitivity of Intramedullary Rods”

Principal Investigator

                Richard Kyle, MD 

Amount and Date funded 

                $10,000                 January 1994

Presentations

                Orthopaedic Trauma Association; AmericanAcademy of Orthopaedic Surgeons

Publications

                Preparing for publication

Additional Grants and Awards

                None

Project Status

                Project concluded.

 


 

Title of Grant       

                “The Effect of Intramedullary Nail Design and Insertion Method on Blood Flow in a

                Tibia Fracture Model”

Principal Investigator

                Emil Schemitsch, MD 

Amount and Date funded 

                $9,690                   February 1994

Presentations

Orthopaedic Trauma Association, October 1997; Canadian Orthopaedic Research Society, June 1997; Canadian Orthopaedic Association, June 1998; International Society for Fracture Repair, September 1998; American Academy of Orthopaedic Surgeon, March 1998; Orthopaedic Trauma Association, October 1998

Publications

                Journal of Orthopaedic Trauma, vol. 12 (6), 1998

                2nd publication submitted to Journal of Orthopaedic Trauma

Additional Grants and Awards

                Grant/Award Title: “Assessment of single fiber implantable laser Doppler

                Flowmetry in a canine segmental tibial fracture model.”

                Physicians Service Incorporated Foundation

                Amount Awarded: $46,540               

                Funding Cycle: 1996 - 1997

Project Status

                Project Concluded


 

Title of Grant       

                “Unilateral Facet Fracture in C-Spine”

Principal Investigator

                Stephen Belkoff, MD

 Amount and Date funded 

                $10,000                 February, 1994

Presentations

                None

Publications

                None

Additional Grants and Awards

                None

Project Status

                2000 – Injury creation phase is complete. Repair phase is better than half complete

                2001 - (15/18 specimens). The remaining 3 spines have been harvested and await

                  Testing in August.
                2004 – Project completed


 

Title of Grant       

                “Pulmonary Sequelae After Reamed Intramedullary Femoral Nailing in Patients with

                Multiple Trauma - Differences According to Reamer Systems”

Principal Investigator

                Hans-Christoph Pape, MD 

Amount and Date funded 

                $10,000                 February 1994

Presentations

                South German Congress of Surgery, 1995; International Symposium of the Science of IM

  Reaming, 1995, Hong Kong; International Congress on Intensive Care

                Medicine, 1997, Bremen, Germany; OTA/AAST October 2000 “Major secondary surgery

                in blunt trauma patients and preoperative cytokrim liberation” Pape et al;

Publications        

                Critical Care Medicine, (in press) Vol. 28, no. 10 “Biochemical changes after

                Trauma and Skeletal surgery of the lower extremity: Qualification of the operative

                burden” Paper et al.; Journal of Trauma submission August 2000.

Additional Grants and Awards

                Grant Award/Title: AO/ASIT MP-65

                Amount Awarded: $108,000

                Funding Cycle: 2 years

Project Status

                Project Completed

 


Title of Grant       

                “The Osteogenic Response to Bleeding and Intramedullary Trauma”

Principal Investigator

                Thomas Einhorn, MD 

Amount and Date funded 

                $19,604                 May 1994

Presentations

                American Orthopaedic Association, 1993

                Orthopaedic Research Society, 1996

Publications
                Clinical Orthopaedics and Related Research, 1997

Additional Grants and Awards

                None

Project Status: Project Complete 


Title of Grant       

                “Consequences of Acetabular Fractures on Load Transmission Across the Hip Joint”

Principal Investigator

                Steven Olson, MD 

Amount and Date funded 

                $20,000                 February 1994 and January 1995

Presentations

American Academy of Orthopaedic Surgeons, 1993 and 1995; Orthopaedic Trauma Association, September 1996, October 1997 and October 1998; International Consensus on Surgery of the Pelvis and Acetabulum, 1994, 1996, and 1998; Western Orthopaedic Association, August 1996; International Symposium for Results of Surgically Treated Acetabular Fractures, Paris, France, 1993.         

Publications

                Journal of Bone and Joint Surgery, vol. 8, 1995; Journal of Orthopaedic Trauma,

                vol. 10, 1996; Journal of Biomechanics, vol. 30, February 1997; Clinical Orthopaedics

                and Related Research, June 1997; Journal of Orthopaedic Trauma, vol. 12, 1998;

                Journal of Orthopaedic Trauma, March/April 1998; Journal of Bone and Joint Surgery,

                vol. 80A(12), 1998; Journal of Orthopaedic Trauma, vol. 13 (6), 1999

Additional Grants and Awards

                Grant/Award Title: AO/ASIF

                Amount Awarded:  $16,000

                Funding Cycle: 1996-1997               
Grant/Award Title: OTA

                Amount Awarded: $10,000

                Funding Cycle: 1997

Project Status

                2001 – Project Concluded

 

…………………………………………………………………………………………………………………………

 

1993

 

 

OTA 1993 GRANT AWARDS

 (Grant Cycle:  January 1, 1993 – December 31, 1993)

 

 

 

Title of Grant       

                “Internal Fixation of Experimental Calcaneus Fractures: A Biomechanical Analysis of

                Two Fixation Methods”

Principal Investigator

                James Carr, MD 

Amount and Date funded 

                $14,000                 January, 1993

Presentations

                Virginia Orthopedic Society, 1994; MCV Resident's Day 1995

                Virginia Orthopedic Society, 1996; Minimal Invasive Traumatology, Austria,

                1996

Publications

                Journal of Orthopaedic Trauma, vol. 11, 1997

Additional Grants and Awards

                None

Project Status

                Project Concluded 

Title of Grant       

                “The Strength of Plate Fixation in Relation to the Number, Spacing and Holding

                              Power of Bone Screws”

Principal Investigator

                Trevor Hearn, PhD 

Amount and Date funded 

                $10,000                 January 1993

Presentations

                None

Publications

                None

Additional Grants and Awards

                None

Project Status

                Project concluded. 

 


 

Title of Grant       

                “Bone Toxicity of Locally Applied Antibiotics”

Principal Investigator

                Theodore Miclau, MD

Amount and Date funded 

                $10,000                 January 1993

Presentations

Orthopaedic Research Society, 40th Annual Meeting, February 1994; American Orthopaedic Association, 27th Annual Resident's Meeting, March 1994; American Orthopaedic Association, 107th Annual Meeting, June 1994; Orthopaedic Trauma Association, Annual Meeting, September 1994; American Academy of Orthopaedic Surgeons, 62nd Annual Meeting, February 1995; Orthopaedic Research Society, 41st Annual Meeting, February 1996; American Academy of Orthopaedic Surgeons, 63rd Annual Meeting, February 1996

Publications

                Journal of Orthopaedic Trauma, vol. 9, 1995

                Clinical Orthopaedics and Related Research, vol. 333, 1996

Additional Grants and Awards

                OTA, January 1998                $9,465

                "The Effects of locally applied antibiotics on human fibroblasts and t-lymphocytes

                in-vitro"

Project Status

                1999 - An additional project manuscript is in preparation entitled "Gentamicin

                Wound Irrigation."

                2002 – Project Concluded

 



Title of Grant       

                “Development of Quantitative Predictors of Fixation in Femoral Neck Fractures”

Principal Investigator

                Allan Tencer, PhD
Amount and Date funded 

                $14,000                 January 1993

Presentations

                Orthopaedic Trauma Association; Orthopaedic Research Society

Publications

                Journal of Orthopaedic Research, vol. 14, 1996

                Journal of Orthopaedic Trauma, vol. 10, 1996

                Journal of Orthopaedic Trauma, vol. 11, 1997
                Injury 32:223-228, 2001

Additional Grants and Awards

                Grant/Award Title: OREF

                Amount Awarded: $98,000

                Grant/Award Title: Norian Corp.

                Amount Awarded: $50,000

Project Status

                Project concluded.

…………………………………………………………………………………………………………………………

 

1992

 

 

OTA 1992 GRANT AWARDS

 (Grant Cycle:  January 1, 1992 – December 31, 1992)

 

 

 

Title of Grant       

                “Periosteal Injury”

Principal Investigator

                James Nepola, MD 

Amount and Date funded 

                $13,000                 1992

Presentations

                Iowa Alumni Meeting, 1996              

Publications

                None

Additional Grants and Awards

                None

Project Status

                Project concluded.


Title of Grant       

                “Galium Nitrate”

Principal Investigator

                Charles Cornell, MD 

Amount and Date funded 

                $11,500                 1992

Presentations

                None

Publications

                None

Additional Grants and Awards

                None

Project Status

                Project Concluded


 

Title of Grant       

                “A Multi-Centre Randomized Controlled Clinical Trial Comparing Operative and

                 Non-operative Treatment of Displaced Intra-Articular Fractures of the Calcaneus”

Principal Investigator

                Richard Buckley, MD

 Amount and Date funded 

                $10,000 January, 1992      renewed $10,000               January, 1993

Presentations

CAA, 1994; CAA, 1995; International Society of Biomechanics; Orthopaedic Trauma Association, 1996; Canadian Orthopaedic Association Meeting, May 1996; Orthopaedic Trauma Association Meeting, September 1996; Canadian Orthopaedic Association Meeting, June 1997; Orthopaedic Trauma Association Meeting, October 1997; American Academy of Orthopaedic Surgeons, February 1997; World Combined Meeting, New Zealand, February 1998; Orthopaedic Trauma Association Meeting, October 1998; American Academy of Orthopaedic Surgeons, March 1998; Canadian Orthopaedic Association Meeting, June 1998; Canadian Orthopaedic Association Meeting, July 1999; Orthopaedic Trauma Association, October 2000; American Academy of Orthopaedic Surgeons, February 2001; American Orthopaedic Foot and Ankle Society, 2001

Publications

                Journal of Bone and Joint Surgeons, vol. 78B, January 1996; Foot and Ankle

                International, vol. 18, no. 4, April 1997; Foot and Ankle International, vol. 19,

                no. 10, October 1998; Journal of Orthopaedic Trauma, vol. 13, no. 8, 1999; Journal of

Orthopaedic Trauma, vol. 15, no. 4, 2001
“The Female Calcaneal Fracture," Journal of Orthopaedic Trauma

“CT Correlations of Displaced Intra-Articular Calcaneal Fractures,” JOT

                “Complications of Management of Calcaneal Fractures,” Journal of Orthopaedic Trauma

                “Subtalar Motion Correlations with Long Term Outcome” Foot & Ankle International

Additional Grants and Awards

                Grant/Award Title: Pharmacia Grant/DVT Study

                Amount Awarded: $250,000

                Funding Cycle: 2000-2002
                Edwin G. Bovill, Jr., MD OTA Specialty Day Award Winning Paper - 2000 OTA

               Annual Meeting

Project Status

Project Status and Long-Term Impact of Research Award: This particular study has won significant awards wherever it has gone. It has been presented to the Canadian Orthopaedic Association, Foot & Ankle portion of the AmericanAcademy, Orthopaedic Trauma Association and to the American Academy Specialty Day. It won the Samson Award ($15,000) for best research submitted to the Canadian Orthopaedic Association Meeting. It won the Bovill Award as the best research for the year 2000 at the OTA. It has continued to enlighten people about calcaneal fractures and will be the definitive paper on displaced intra-articular fracture management when it is published. Initial funding was instrumental in its reaching these heights.

              2001 – Project Concluded

…………………………………………………………………………………………………………………………

 

1991

 

 

OTA 1991 GRANT AWARDS

 (Grant Cycle:  January 1, 1991 – December 31, 1991)

 

 

  

Title of Grant       

                “Stability Evaluation and Comparison of Posterior, Anterior and Transpedicular Screw

                and Spinal Implants”

Principal Investigator

                Jeffery Stambough, MD 

Amount and Date funded 

                $10,000 and 8,000              1991 and 1992

Presentations

                University of Cincinnati

Publications

                Journal of Special Disorders, 1998

Additional Grants and Awards

                Yes, $25,000 in 1998

Project Status

                Project Concluded

 


 

 …………………………………………………………………………………………………………………………

 

1990

 

 

OTA 1990 GRANT AWARDS

 (Grant Cycle:  January 1, 1990 – December 31, 1990)

 

 

 

Title of Grant       

                “Effect of Isolated Talo Calcaneal Fusion on Contracting the Ankle and Talonavicular

                Joint”

Principal Investigator

                Robert Adelaar, MD 

Amount and Date funded 

                $7,500                   1990

Presentations

                American Orthopaedic Foot and Ankle Society; Orthopaedic Club; Southern

 Orthopaedic Association; Virginia Orthopaedic Association; Orthopedic Research

 Society; Pediatric Orthopedic Society; Piedmont Orthopedic Meeting

Publications

                Foot and Ankle Journal, vol. 12, 1991

Additional Grants and Awards

                None

Project Status

                Project Concluded


 

Title of Grant       

                "Mortality of Poly-trauma Patients with Early Fracture Management"

Principal Investigator

                Lawrence Bone, MD

 Amount and Date funded 

                $2,000                   1990 & 1991

Presentations

                Orthopaedic Trauma Association, 1993; AAST Annual Meeting 1993

Publications

                Journal of Trauma, vol. 8, 1994

Additional Grants and Awards

                None

Project Status

                Project Concluded

 


 …………………………………………………………………………………………………………………………

 

 

 

 

 

 

Multi-Center Study

 

 

 

 

Title of Study

                "Immediate Versus Delayed Closure of Grade II and IIIA Tibia Fractures"

Grant Funded by

 OTA

Chair        William DeLong, MD  

Amount and Date funded 

                $205,781                                               Funding Cycle: May 2000 – May 2002


The orthopaedic axiom that all open fractures should remain open until redebrided and closed in a delayed fashion dates back to Trueta.  It has never been tested in modern times by a randomized prospective trial.  It is currently the practice of many surgeons to primarily close open fractures, if closeable, after aggressive debridement and irrigation.  The argument supporting this practice is that the wound will never be cleaner than it is at that period of time, and with a closed wound, the wound is protected from possible contamination by resistant organisms from the hospital.  Literature on this topic is based on anecdotal experiences, personal exclamations, and “no true science” and does not currently support this approach in adult patients.  This project has been designed to determine if there is a clinical and economic advantage to the patient with immediate fracture closure. Thirty North American trauma centers are participating in the study and beginning August 2001 data-entry from the twenty-three sites has been web-based.

 

 

 

 

 

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